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Graefe's Archive for Clinical and Experimental Ophthalmology
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology 1/2018

25.11.2017 | Review Article

Laser photocoagulation as treatment of non-exudative age-related macular degeneration: state-of-the-art and future perspectives

verfasst von: Giuseppe Querques, Maria Vittoria Cicinelli, Alessandro Rabiolo, Luigi de Vitis, Riccardo Sacconi, Lea Querques, Francesco Bandello

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 1/2018

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Abstract

Purpose

To give an updated review of laser approaches to non-exudative age-related macular degeneration (AMD).

Methods

PubMed and Medline database searches were carried out using the terms “laser” and “photocoagulation” associated with “age-related macular degeneration”, and latest publications up to May 2017 have been reviewed. Moreover, the design of an ongoing single-center, non-randomized, phase I–II, pilot study, the PASCAL-GA trial, coordinated by F. Bandello, MD and G. Querques, MD from the IRCCS Ospedale San Raffaele, is described.

Results

Either standard or subthreshold laser strategies have been tried to induce regression of distinct phenotypes of AMD, as reticular pseudodrusen (RPD), nascent geographic atrophy (nGA), and drusen-associated geographic atrophy (DAGA), with heterogeneous results. The aim of the PASCAL-GA protocol is to assess if subthreshold laser can restore the retinal pigment epithelium function in eyes with RPD and nGA offering a protective effect against extensive GA.

Conclusions

New-generation medical and surgical approaches, including subthreshold laser photocoagulation, may have some success in downstaging AMD.
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Metadaten
Titel
Laser photocoagulation as treatment of non-exudative age-related macular degeneration: state-of-the-art and future perspectives
verfasst von
Giuseppe Querques
Maria Vittoria Cicinelli
Alessandro Rabiolo
Luigi de Vitis
Riccardo Sacconi
Lea Querques
Francesco Bandello
Publikationsdatum
25.11.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 1/2018
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-017-3848-x

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