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Experimental Brain Research

Erschienen in:

01.04.2012 | Review

Regulation of alpha-secretase ADAM10 expression and activity

verfasst von: Kristina Endres, Falk Fahrenholz

Erschienen in: Experimental Brain Research | Ausgabe 3-4/2012

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Abstract

The amyloid precursor protein (APP) has a pivotal role in pathogenesis of Alzheimer’s disease (AD) via its beta- and gamma-secretase-derived cleavage products—the A-beta peptides. An alternative processing pathway provided by the alpha-secretase prevents formation of those toxic peptides and gives rise to the neurotrophic and neuroprotective cleavage product APPs-alpha. The molecular identity of the alpha-secretase has been confirmed recently, and there is consistency about ADAM10 being the most relevant and physiological enzyme of this class. It is not clear to what extent a deficiency in the catalytic activity of ADAM10 contributes to AD pathology and whether a decline occurs in aging humans. Nevertheless, ADAM10 has been suggested as a valuable target for prevention and/or for treatment of Alzheimer’s disease. This review focuses on our knowledge about regulation of ADAM10 on different levels of cell physiology, such as transcription and translation, as well as protein–protein interactions and how this especially in the case of transcriptional regulation by retinoic acids might lead to the development of new therapeutic approaches.

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Titel: Regulation of alpha-secretase ADAM10 expression and activity
verfasst von: Kristina Endres
Falk Fahrenholz
Publikationsdatum: 01.04.2012
Verlag: Springer-Verlag
Erschienen in: Experimental Brain Research / Ausgabe 3-4/2012
Print ISSN: 0014-4819
Elektronische ISSN: 1432-1106
DOI: https://doi.org/10.1007/s00221-011-2885-7

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