nach oben

Calcified Tissue International

Erschienen in:

01.12.2003 | Review

Diabetes Mellitus: Does it Affect Bone?

verfasst von: A. V. Schwartz

Erschienen in: Calcified Tissue International | Ausgabe 6/2003

Einloggen, um Zugang zu erhalten

Abstract

Both diabetes and fractures affect a large proportion of older adults. Recent cohort studies indicate that diabetes itself is associated with increased risk of fracture of the hip, proximal humerus, and foot. Observational studies and animal models suggest that decreased bone strength in diabetes may contribute to fracture risk but this remains a controversial issue. Type 1 diabetes is associated with modest reductions in bone mineral density (BMD) but type 2 diabetes is often characterized by elevated BMD. This paradox of higher BMD but increased fracture risk in type 2 diabetes may be explained by a combination of more frequent falls and poorer bone quality. Diabetes can impact bone through multiple pathways, some with contradictory effects, including obesity, changes in insulin levels, higher concentrations of advanced glycation end products in collagen, hypercalciuria associated with glycosuria, reduced renal function, lower insulin-like growth factor-I, microangiopathy, and inflammation. A better understanding of how diabetes metabolism and treatments affect bone would improve fracture prevention efforts in older diabetic adults.

Lieberman, D, Fried, V, Castel, H, Weitzmann, S, Lowenthal, MN, Galinsky, D 1996Factors related to successful rehabilitation after hip fracture: a case-control study.Disabil Rehabil18224230CrossRefPubMed

Dubey, A, Aharonoff, GB, Zuckerman, JD, Koval, KJ 2000The effects of diabetes on outcome after hip fracture.Bull Hosp Jt Dis599498PubMed

Loder RT (1988) The influence of diabetes mellitus on the healing of closed fractures. Clin Orthop, pp 210–216

Beam, HA, Parsons, JR, Lin, SS 2002The effects of blood glucose control upon fracture healing in the BB Wistar rat with diabetes mellitus.J Orthop Res2012101216CrossRefPubMed

Schwartz, AV, Sellmeyer, DE, Ensrud, KE, Cauley, JA, Tabor, HK, Schreiner, PJ, Black, DM, Cummings, SR 2001Older women with diabetes have an increased risk of fracture: a prospective study.J Clin Endocrinol Metab863238CrossRefPubMed

Nicodemus, KK, Folsom, AR 2001Type 1 and type 2 diabetes and incident hip fractures in postmenopausal women.Diabetes Care2411921197CrossRefPubMed

Forsen, L, Meyer, HE, Midthjell, K, Edna, TH 1999Diabetes mellitus and the incidence of hip fracture: results from the Nord-Trondelag Health Survey.Diabetologia42920925CrossRefPubMed

Meyer, HE, Tverdal, A, Falch, JA 1993Risk factors for hip fracture in middle-aged Norwegian women and men.Am J Epidemiol13712031211PubMed

Ottenbacher, KJ, Ostir, GV, Peek, MK, Goodwin, JS, Markides, KS 2002Diabetes mellitus as a risk factor for hip fracture in Mexican American older adults.J Gerontol A Biol Sci Med Sci57M648653CrossRefPubMed

10.

Keegan, TH, Kelsey, JL, Sidney, S, Quesenberry Jr, CP 2002Foot problems as risk factors of fractures.Am J Epidemiol155926931CrossRefPubMed

11.

Felson, DT, Zhang, Y, Hannan, MT, Anderson, JJ 1993Effects of weight and body mass index on bone mineral density in men and women: the Framingham study.J Bone Miner Res8567573CrossRefPubMed

12.

Thomas, T, Burguera, B, Melton, LJ, Atkinson, EJ, O’Fallon, WM, Riggs, BL, Khosla, S 2001Role of serum leptin, insulin, and estrogen levels as potential mediators of the relationship between fat mass and bone mineral density in men versus women.Bone29114120CrossRefPubMed

13.

Reid, IR, Evans, MC, Cooper, GJ, Ames, RW, Stapleton, J 1993Circulating insulin levels are related to bone density in normal postmenopausal women.Am J Physiol265E655E659PubMed

14.

Paul, RG, Bailey, AJ 1996Glycation of collagen: the basis of its central role in the late complications of ageing and diabetes.Int J Biochem Cell Biol2812971310CrossRefPubMed

15.

Gregorio, F, Cristallini, S, Santeusanio, F, Filipponi, P, Fumelli, P 1994Osteopenia associated with non-insulin-dependent diabetes mellitus: What are the causes?Diabetes Res Clin Pract234354CrossRefPubMed

16.

Ward, DT, Yau, SK, Mee, AP, Mawer, EB, Miller, CA, Garland, HO, Riccardi, D 2001Functional, molecular, and biochemical characterization of streptozotocin-induced diabetes.J Am Soc Nephrol12779790PubMed

17.

Raskin, P, Stevenson, MR, Barilla, DE, Pak, CY 1978The hypercalciuria of diabetes mellitus: its amelioration with insulin.Clin Endocrinol (Oxf)9329335CrossRef

18.

Dills, DG, Allen, C, Palta, M, Zaccaro, DJ, Klein, R, D’Alessio, D 1995Insulin-like growth factor-I is related to glycemic control in children and adolescents with newly diagnosed insulin-dependent diabetes.J Clin Endocrinol Metab8021392143PubMed

19.

Baylink, DJ, Finkelman, RD, Mohan, S 1993Growth factors to stimulate bone formation.J Bone Miner Res8S565572PubMed

20.

Jehle, PM, Jehle, DR, Mohan, S, Bohm, BO 1998Serum levels of insulin-like growth factor system components and relationship to bone metabolism in type 1 and type 2 diabetes mellitus patients.J Endocrinol159297306CrossRefPubMed

21.

Manolagas, SC, Jilka, RL 1995Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis.N Engl J Med332305311CrossRefPubMed

22.

Pickup, JC, Crook, MA 1998Is type II diabetes mellitus a disease of the innate immune system?Diabetologia4112411248CrossRefPubMed

23.

Yendt, ER, Cohanim, M, Jarzylo, S, Jones, G, Rosenberg, G 1993Reduced creatinine clearance in primary osteoporosis in women.J Bone Miner Res810451052CrossRefPubMed

24.

Wientroub, S, Eisenberg, D, Tardiman, R, Weissman, SL, Salama, R 1980Is diabetic osteoporosis due to microangiopathy?Lancet2983CrossRefPubMed

25.

Burkhardt, R, Moser, W, Bartl, R, Mahl, G 1981Is diabetic osteoporosis due to microangiopathy?Lancet1844CrossRefPubMed

26.

McNair, P, Christensen, MS, Christiansen, C, Madsbad, S, Transbol, I 1981Is diabetic osteoporosis due to microangiopathy?Lancet11271CrossRefPubMed

27.

Vogt, MT, Cauley, JA, Kuller, LH, Nevitt, MC 1997Bone mineral density and blood flow to the lower extremities: the study of osteoporotic fractures.J Bone Miner Res12283289CrossRefPubMed

28.

Amir, G, Rosenmann, E, Sherman, Y, Greenfeld, Z, Ne’eman, Z, Cohen, AM 2002Osteoporosis in the Cohen diabetic rat: correlation between histomorphometric changes in bone and microangiopathy.Lab Invest8213991405CrossRefPubMed

29.

Tuominen, JT, Impivaara, O, Puukka, P, Ronnemaa, T 1999Bone mineral density in patients with type 1 and type 2 diabetes.Diabetes Care2211961200CrossRefPubMed

30.

McNair, P, Christiansen, C, Christensen, MS, Madsbad, S, Faber, OK, Binder, C, Transbol, I 1981Development of bone mineral loss in insulin-treated diabetes: a 1 1/2 years follow-up study in sixty patients.Eur J Clin Invest115559CrossRefPubMed

31.

Forst, T, Pfutzner, A, Kann, P, Schehler, B, Lobmann, R, Schafer, H, Andreas, J, Bockisch, A, Beyer, J 1995Peripheral osteopenia in adult patients with insulin-dependent diabetes mellitus.Diabetes Med12874879CrossRef

32.

Buysschaert, M, Cauwe, F, Jamart, J, Brichant, C, De Coster, P, Magnan, A, Donckier, J 1992Proximal femur density in type 1 and 2 diabetic patients.Diabetes Metab183237

33.

Hui, SL, Epstein, S, Johnston Jr, CC 1985A prospective study of bone mass in patients with type I diabetes.J Clin Endocrinol Metab607480CrossRefPubMed

34.

Miazgowski, T, Czekalski, S 1998A 2-year follow-up study on bone mineral density and markers of bone turnover in patients with long-standing insulin-dependent diabetes mellitus.Osteoporos Int8399403CrossRefPubMed

35.

Mathiassen, B, Nielsen, S, Johansen, JS, Hartwell, D, Ditzel, J, Rodbro, P, Christiansen, C 1990Long-term bone loss in insulin-dependent diabetic patients with microvascular complications.J Diabetes Complications4145149CrossRef

36.

Levin, ME, Boisseau, VC, Avioli, LV 1976Effects of diabetes mellitus on bone mass in juvenile and adult-onset diabetes.N Engl J Med294241245CrossRefPubMed

37.

Olmos, JM, Perez-Castrillon, JL, Garcia, MT, Garrido, JC, Amado, JA, Gonzalez-Macias, J 1994Bone densitometry and biochemical bone remodeling markers in type 1 diabetes mellitus.Bone Miner2618CrossRefPubMed

38.

Heath, H, Melton, LJ, Chu, CP 1980Diabetes mellitus and risk of skeletal fracture.N Engl J Med303567570CrossRefPubMed

39.

Melchior TM, Sorensen H, Torp-Pedersen C (1994) Hip and distal arm fracture rates in peri- and postmenopausal insulin-treated diabetic females. J Intern Med, pp 203–208

40.

Verhaeghe, J, Suiker, AM, Einhorn, TA, Geusens, P, Visser, WJ, Van Herck, E, van Bree, R, Magitsky, S, Bouillon, R 1994Brittle bones in spontaneously diabetic female rats cannot be predicted by bone mineral measurements: studies in diabetic and ovariectomized rats.J Bone Miner Res916571667CrossRefPubMed

41.

Bjorgaas, M, Haug, E, Johnsen, HJ 1999The urinary excretion of deoxypyridinium cross-links is higher in diabetic than in nondiabetic adolescents.Calcif Tissue Int65121124CrossRefPubMed

42.

Selby, PL, Shearing, PA, Marshall, SM 1995Hydroxyproline excretion is increased in diabetes mellitus and related to the presence of microalbuminuria.Diabetes Med12240243CrossRef

43.

Christensen, JO, Svendsen, OL 1999Bone mineral in pre- and postmenopausal women with insulin-dependent and non-insulin-dependent diabetes mellitus.Osteoporos Int10307311CrossRefPubMed

44.

Pedrazzoni, M, Ciotti, G, Pioli, G, Girasole, G, Davoli, L, Palummeri, E, Passeri, M 1989Osteocalcin levels in diabetic subjects.Calcif Tissue Int45331336CrossRefPubMed

45.

Gallacher, SJ, Fenner, JA, Fisher, BM, Quin, JD, Fraser, WD, Logue, FC, Cowan, RA, Boyle, IT, MacCuish, AC 1993An evaluation of bone density and turnover in premenopausal women with type 1 diabetes mellitus.Diabetes Med10129133CrossRef

46.

Munoz-Torres, M, Jodar, E, Escobar-Jimenez, F, Lopez-Ibarra, PJ, Luna, JD 1996Bone mineral density measured by dual X-ray absorptiometry in Spanish patients with insulin-dependent diabetes mellitus.Calcif Tissue Int58316319CrossRefPubMed

47.

van Daele, PL, Stolk, RP, Burger, H, Algra, D, Grobbee, DE, Hofman, A, Birkenhager, JC, Pols, HA 1995Bone density in non-insulin-dependent diabetes mellitus. The Rotterdam Study.Ann Intern Med122409414CrossRefPubMed

48.

Krakauer, JC, McKenna, MJ, Buderer, NF, Rao, DS, Whitehouse, FW, Parfitt, AM 1995Bone loss and bone turnover in diabetes.Diabetes44775782CrossRefPubMed

49.

Kao, CH, Tsou, CT, Chen, CC, Wang, SJ 1993Bone mineral density in patients with noninsulin-dependent diabetes mellitus by dual photon absorptiometry.Nucl Med Commun14373377CrossRefPubMed

50.

Wakasugi, M, Wakao, R, Tawata, M, Gan, N, Koizumi, K, Onaya, T 1993Bone mineral density measured by dual energy x-ray absorptiometry in patients with non-insulin-dependent diabetes mellitus.Bone142933CrossRefPubMed

51.

Okuno, Y, Nishizawa, Y, Sekiya, K, Hagiwara, S, Miki, T, Morii, H 1991Total and regional bone mineral content in patients with non-insulin-dependent diabetes mellitus.J Nutr Sci Vitaminol (Tokyo)37S43S49CrossRef

52.

Hampson, G, Evans, C, Petitt, RJ, Evans, WD, Woodhead, SJ, Peters, JR, Ralston, SH 1998Bone mineral density, collagen type 1 alpha 1 genotypes and bone turnover in premenopausal women with diabetes mellitus.Diabetologia4113141320CrossRefPubMed

53.

Bauer, DC, Browner, WS, Cauley, JA, Orwoli, ES, Scott, JC, Black, DM, Tao, JL, Cummings, SR 1993Factors associated with appendicular bone mass in older women. The Study of Osteoporotic Fractures Research Group .Ann Intern Med118657665CrossRefPubMed

54.

Orwoll, ES, Bauer, DC, Vogt, TM, Fox, KM 1996Axial bone mass in older women. Study of Osteoporotic Fractures Research Group.Ann Intern Med124187196CrossRefPubMed

55.

Barrett-Connor, E, Holbrook, TL 1992Sex differences in osteoporosis in older adults with non-insulin-dependent diabetes mellitus.JAMA26833333337CrossRefPubMed

56.

Isaia, GC, Ardissone, P, Di Stefano, M, Ferrari, D, Martina, V, Porta, M, Tagliabue, M, Molinatti, GM 1999Bone metabolism in type 2 diabetes mellitus.Acta Diabetol363538CrossRefPubMed

57.

Barrett-Connor, E, Kritz-Silverstein, D 1996Does hyperinsulinemia preserve bone?Diabetes Care1913881392CrossRefPubMed

58.

Stolk, RP, van Daele, PL, Pols, HA, Burger, H, Hofman, A, Birkenhager, JC, Lamberts, SW, Grobbee, DE 1996Hyperinsulinemia and bone mineral density in an elderly population: The Rotterdam Study [published erratum appears in Bone 1996 Nov;19(5):566].Bone18545549CrossRefPubMed

59.

Nelson, DA, Jacober, SJ 2001Why do older women with diabetes have an increased fracture risk?J Clin Endocrinol Metab862931CrossRefPubMed

60.

Schwartz, AV, Hillier, TA, Sellmeyer, DE, et al. 2002Older women with diabetes have a higher risk of falls: a prospective study.Diabetes Care2517491754CrossRefPubMed

61.

Gregg, EW, Mangione, CM, Cauley, JA, Thompson, TJ, Schwartz, AV, Ensrud, KE, Nevitt, MC 2002Diabetes and incidence of functional disability in older women.Diabetes Care256167CrossRefPubMed

62.

Hanlon, JT, Landerman, LR, Fillenbaum, GG, Studenski, S 2002Falls in African American and white community-dwelling elderly residents.J Gerontol A Biol Sci Med Sci57M473M478CrossRefPubMed

63.

Cummings, SR, Nevitt, MC 1989A hypothesis: the causes of hip fractures.J Gerontol44M107111CrossRefPubMed

64.

Tinetti, ME, Doucette, J, Claus, E, Marottoli, R 1995Risk factors for serious injury during falls by older persons in the community.J Am Geriatr Soc4312141221CrossRefPubMed

65.

Nevitt, MC, Cummings, SR, Hudes, ES 1991Risk factors for injurious falls: a prospective study.J Gerontol46M164M170CrossRefPubMed

66.

O’Loughlin, JYR, Boivin, J, Suissa, S 1993Incidence of and risk factors for falls and injurious falls among the community-dwelling elderly.Am J Epidemiol137342354PubMed

67.

Reddy, GK, Stehno-Bittel, L, Hamade, S, Enwemeka, CS 2001The biomechanical integrity of bone in experimental diabetes.Diabetes Res Clin Pract5418CrossRefPubMed

68.

Verhaeghe, J, van Herck, E, Visser, WJ, Suiker, AM, Thomasset, M, Einhorn, TA, Faierman, E, Bouillon, R 1990Bone and mineral metabolism in BB rats with long-term diabetes. Decreased bone turnover and osteoporosis.Diabetes39477482CrossRefPubMed

69.

Einhorn, TA, Boskey, AL, Gundberg, CM, Vigorita, VJ, Devlin, VJ, Beyer, MM 1988The mineral and mechanical properties of bone in chronic experimental diabetes.J Orthop Res6317323CrossRefPubMed

70.

Brownlee, M, Cerami, A, Vlassara, H 1988Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications.N Engl JMed31813151321CrossRef

71.

Wang, X, Shen, X, Li, X, Agrawal, CM 2002Age-related changes in the collagen network and toughness of bone.Bone3117CrossRefPubMed

72.

Vashishth, D, Gibson, GJ, Khoury, JI, Schaffler, MB, Kimura, J, Fyhrie, DP 2001Influence of nonenzymatic glycation on biomechanical properties of cortical bone.Bone28195201CrossRefPubMed

73.

Katayama, Y, Akatsu, T, Yamamoto, M, Kugai, N, Nagata, N 1996Role of nonenzymatic glycosylation of type I collagen in diabetic osteopenia.J Bone Miner Res11931937CrossRefPubMed

74.

Miyata, T, Notoya, K, Yoshida, K, Hone, K, Maeda, K, Kurokawa, K, Taketomi, S 1997Advanced glycation end products enhance osteoclast-induced bone resorption in cultured mouse unfractionated bone cells and in rats implanted subcutaneously with devitalized bone particles.J Am Soc Nephrol8260270PubMed

75.

Takagi, M, Kasayama, S, Yamamoto, T, Motomura, T, Hashimoto, K, Yamamoto, H, Sato, B, Okada, S, Kishimoto, T 1997Advanced glycation end products stimulate interleukin-6 production by human bone-derived cells.J Bone Miner Res12439446CrossRefPubMed

76.

McCarthy, AD, Etcheverry, SB, Cortizo, AM 1999Advanced glycation endproduct-specific receptors in rat and mouse osteoblast-like cells: regulation with stages of differentiation.Acta Diabetol364552CrossRefPubMed

77.

Riis, BJ, Hansen, MA, Jensen, AM, Overgaard, K, Christiansen, C 1996Low bone mass and fast rate of bone loss at menopauses, equal risk factors for future fracture: a 15-year follow-up study.Bone19912CrossRefPubMed

78.

Schwartz, AV, Sellmeyer, DE, Nevitt, MC, Resnick, HE, Margolis, KL, Hillier, TA, Black, DM, Ensrud, KE, Cummings, SR 2000Older women with diabetes have a higher rate of bone loss at the hip.J Bone Miner Res15S188

79.

Moritz, DJ, Ostfeld, AM, Blazer, D, Curb, D, Taylor, JO, Wallace, RB 1994The health burden of diabetes for the elderly in four communities.Public Health Rep109782790PubMedPubMedCentral

80.

Looker, HC, Knowler, WC, Hanson, RL 2001Changes in BMI and weight before and after the development of type 2 diabetes.Diabetes Care2419171922CrossRefPubMed

81.

Bouillon, R 1991Diabetic bone disease.Calcif Tissue Int49155160CrossRefPubMed

82.

Ensrud, KE, Cauley, JA, Zhou, L, Mason, TM, Bowman, PJ, Harper, KD 2001Effect of raloxifene hydrochloride (RLX) on bone mineral density (BMD) and bone turnover markers in diabetic women: the Multiple Outcomes of Raloxifene Evaluation (MORE) Trial.J Bone Miner Res16S415

83.

Jude, EB, Selby, PL, Burgess, J, et al. 2001Bisphosphonates in the treatment of Charcot neuroarthropathy: a double-blind randomised controlled trial.Diabetologia4420322037CrossRefPubMed

Titel: Diabetes Mellitus: Does it Affect Bone?
verfasst von: A. V. Schwartz
Publikationsdatum: 01.12.2003
Verlag: Springer New York
Erschienen in: Calcified Tissue International / Ausgabe 6/2003
Print ISSN: 0171-967X
Elektronische ISSN: 1432-0827
DOI: https://doi.org/10.1007/s00223-003-0023-7

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

NSCLC: Progressionsfreies Überleben unter Osimertinib fast versiebenfacht

06.06.2024 ASCO 2024 Kongressbericht

Erste Ergebnisse der Phase-III-Studie LAURA etablieren Osimertinib als neuen Therapiestandard für Menschen mit nicht-resezierbarem, EGFR-mutiertem, nicht-kleinzelligem Lungenkarzinom im Stadium III, die nach definitiver Radiochemotherapie progressionsfrei sind. Auf der ASCO-Tagung wurden diese beeindruckenden Ergebnisse besprochen.

Hodgkin Lymphom: BrECADD-Regime übertrifft die Erwartungen

05.06.2024 ASCO 2024 Kongressbericht

Das Kombinationsregime BrECADD mit Brentuximab vedotin ermöglichte in der Studie HD21 beim fortgeschrittenen klassischen Hodgkin-Lymphom eine unerwartet hohe progressionsfreie Überlebensrate von 94,3% nach vier Jahren. Gleichzeitig war das Regime besser tolerabel als der bisherige Standard eBEACOPP.

Antikörper-Drug-Konjugat verdoppelt PFS bei Multiplem Myelom

05.06.2024 ASCO 2024 Nachrichten

Zwei Phase-3-Studien deuten auf erhebliche Vorteile des Antikörper-Wirkstoff-Konjugats Belantamab-Mafodotin bei vorbehandelten Personen mit Multiplem Myelom: Im Vergleich mit einer Standard-Tripeltherapie wurde das progressionsfreie Überleben teilweise mehr als verdoppelt.

Neuer TKI gegen CML: Höhere Wirksamkeit, seltener Nebenwirkungen

05.06.2024 Chronische myeloische Leukämie Nachrichten

Der Tyrosinkinasehemmer (TKI) Asciminib ist älteren Vertretern dieser Gruppe bei CML offenbar überlegen: Personen mit frisch diagnostizierter CML entwickelten damit in einer Phase-3-Studie häufiger eine gute molekulare Response, aber seltener ernste Nebenwirkungen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Adipositas in der Primärversorgung – Herausforderungen und Chancen einer ganzheitlichen Betreuung

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 6/2003

Announcements

A Simulation Model at Trabecular Level to Predict Effects of Antiresorptive Treatment after Menopause

Evaluation of Vertebral Fractures on Lateral Chest Radiographs of Inner-City Postmenopausal Women

Subject Index

Intranasal Delivery of PEGylated Salmon Calcitonins: Hypocalcemic Effects in Rats