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Calcified Tissue International

Erschienen in:

01.06.2005

Cyclic Tensile Stretch Stimulates the Release of Reactive Oxygen Species from Osteoblast-like Cells

verfasst von: N. Yamamoto, K. Fukuda, T. Matsushita, M. Matsukawa, F. Hara, C. Hamanishi

Erschienen in: Calcified Tissue International | Ausgabe 6/2005

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Abstract

It is known that the excessive generation of reactive oxygen species (ROS) is a significant factor in tissue injury observed in many disease states. To determine whether extreme levels of mechanical stress applied to osteoblasts enhances ROS synthesis, we loaded cyclic tensile stretch on osteoblast-like HT-3 cells. Cyclic tensile stretch loaded on these cells clearly enhanced ROS synthesis in a time- and magnitude-dependent fashion. Cyclic tensile stretch also enhanced superoxide dismutase (SOD) activity. The disruption of microfilaments with cytochalasin D abolished the stress-induced ROS synthesis. Rotenone, an inhibitor of the mitochondrial electron transport chain, enhanced stress-induced ROS synthesis. These data suggest that actin filament and mitochondria are involved in this action.

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Titel: Cyclic Tensile Stretch Stimulates the Release of Reactive Oxygen Species from Osteoblast-like Cells
verfasst von: N. Yamamoto
K. Fukuda
T. Matsushita
M. Matsukawa
F. Hara
C. Hamanishi
Publikationsdatum: 01.06.2005
Verlag: Springer-Verlag
Erschienen in: Calcified Tissue International / Ausgabe 6/2005
Print ISSN: 0171-967X
Elektronische ISSN: 1432-0827
DOI: https://doi.org/10.1007/s00223-004-1188-4

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