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Abdominal Radiology
Erschienen in: Abdominal Radiology 3/2013

01.06.2013

Rare hepatic malignant tumors: dynamic CT, MRI, and clinicopathologic features: with analysis of 54 cases and review of the literature

verfasst von: Yan Tan, En-hua Xiao

Erschienen in: Abdominal Radiology | Ausgabe 3/2013

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Abstract

Aim

To evaluate the dynamic CT, MRI, and clinicopathologic characteristics of rare hepatic malignant tumors (HRMTs), improving the understanding and diagnosis of the tumors.

Methods

A retrospective analysis of 54 cases of HRMTs diagnosed by pathology in our hospital during January 1, 2005 to September 1, 2011.

Results

The types of tumors included hepatic sarcoma (n = 8), malignant lymphoma (n = 4), malignant fibrous histiocytoma (MFH, n = 7), malignant melanoma (MM, n = 4), squamous cell carcinoma (SCC, n = 5), primary clear cell carcinoma of the liver (PCCCL, n = 7), stromal tumors (ST n = 4), hepatoblastoma (HB, n = 8), carcinoid (n = 6), primary primitive neuroectodermal tumor (pPNET, n = 1). Age of the patients ranged from 1 to 79 years (mean = 46.7 years). There were more men in this group (34/54). Symptoms of HRMTs show no specificity. Except PCCCL and HB, the serum AFP of most HRMTs was negative. 43 patients had a single hepatic mass, and 11 patients had multiple hepatic masses. Diameters ranged from 2 to 15 cm (mean = 7.7 cm). Precontrast CT revealed that most masses had uneven density (n = 46) and ill-demarcated margin (n = 37). Enhanced CT showed most lesions unevenly enhanced (n = 49), of which PCCCL had a prompt enhancement in the arterial phase and rapid wash-out on the portal venous phase and delayed phase; malignant lymphoma and ST had slight enhancement, MFH and undifferentiated embryonal sarcoma had gradual delayed enhancement. Most masses had low-signal on T1WI and high-signal on T2WI, while MM had high-signal on T1WI and low-signal on T2WI.

Conclusions

Although there is frequent overlap in the CT, MRI, and clinicopathologic appearances between the rare malignant tumors, some HRMTs have characteristic imaging features that can suggest a specific diagnosis.
Literatur
1.
Perilongo G, Shafford EA (1999) Liver tumours. Eur J Cancer 35(953–958):958–959
2.
Finn JP, Hall-Craggs MA, Dicks-Mireaux C, et al. (1990) Primary malignant liver tumors in childhood: assessment of resectability with high-field MR and comparison with CT. Pediatr Radiol 21:34–38. doi:10.​1007/​BF02010811 PubMedCrossRef
3.
Rasalkar DD, Chu WC, Cheng FW, et al. (2010) A pictorial review of imaging of abdominal tumours in adolescence. Pediatr Radiol 40(1552–1561):1589–1590. doi:10.​1007/​s00247-010-1738-z
4.
5.
Wang XW, Liang P, Li HY (2004) Primary hepatic carcinosarcoma: a case report. Chin Med J (Engl) 117:1586–1587
6.
7.
8.
9.
Gates LK, Cameron AJ, Nagorney DM, et al. (1995) Primary leiomyosarcoma of the liver mimicking liver abscess. Am J Gastroenterol 90:649–652PubMed
10.
11.
12.
13.
Locker GY, Doroshow JH, Zwelling LA, et al. (1979) The clinical features of hepatic angiosarcoma: a report of four cases and a review of the English literature. Medicine (Baltimore) 58:48–64CrossRef
14.
Kojiro M, Nakashima T, Ito Y, et al. (1985) Thorium dioxide-related angiosarcoma of the liver. Pathomorphologic study of 29 autopsy cases. Arch Pathol Lab Med 109:853–857PubMed
15.
16.
17.
Buetow PC, Buck JL, Pantongrag-Brown L, et al. (1997) Undifferentiated (embryonal) sarcoma of the liver: pathologic basis of imaging findings in 28 cases. Radiology 203:779–783PubMed
18.
O’Sullivan MJ, Swanson PE, Knoll J, et al. (2001) Undifferentiated embryonal sarcoma with unusual features arising within mesenchymal hamartoma of the liver: report of a case and review of the literature. Pediatr Dev Pathol 4:482–489. doi:10.​1007/​s10024001-0047-9 PubMedCrossRef
19.
Boechat MI, Kangarloo H (1989) MR imaging of the abdomen in children. AJR Am J Roentgenol 152:1245–1250PubMedCrossRef
20.
21.
Sanders LM, Botet JF, Straus DJ, et al. (1989) CT of primary lymphoma of the liver. AJR Am J Roentgenol 152:973–976PubMedCrossRef
22.
Radin DR, Esplin JA, Levine AM, et al. (1993) AIDS-related non-Hodgkin’s lymphoma: abdominal CT findings in 112 patients. AJR Am J Roentgenol 160:1133–1139PubMedCrossRef
23.
24.
25.
Gazelle GS, Lee MJ, Hahn PF, et al. (1994) US, CT, and MRI of primary and secondary liver lymphoma. J Comput Assist Tomogr 18:412–415PubMedCrossRef
26.
27.
28.
29.
30.
Ding GH, Wu MC, Yang JH, et al. (2006) Primary hepatic malignant fibrous histiocytoma mimicking cystadenocarcinoma: a case report. Hepatobiliary Pancreat Dis Int 5:620–623PubMed
31.
Anagnostopoulos G, Sakorafas GH, Grigoriadis K, et al. (2005) Malignant fibrous histiocytoma of the liver: a case report and review of the literature. Mt Sinai J Med 72:50–52PubMed
32.
Ferrozzi F, Bova D (1998) Hepatic malignant fibrous histiocytoma: CT findings. Clin Radiol 53:699–701PubMedCrossRef
33.
Wunderbaldinger P, Schima W, Harisinghani M, et al. (1998) Primary malignant fibrous histiocytoma of the liver: CT and MR findings. AJR Am J Roentgenol 171:900–901PubMedCrossRef
34.
Satyamoorthy K, Herlyn M (2002) Cellular and molecular biology of human melanoma. Cancer Biol Ther 1:14–17PubMed
35.
36.
Rigel DS, Friedman RJ, Kopf AW (1996) The incidence of malignant melanoma in the United States: issues as we approach the 21st century. J Am Acad Dermatol 34:839–847PubMedCrossRef
37.
Damian DL, Fulham MJ, Thompson E, et al. (1996) Positron emission tomography in the detection and management of metastatic melanoma. Melanoma Res 6:325–329PubMedCrossRef
38.
Eigtved A, Andersson AP, Dahlstrom K, et al. (2000) Use of fluorine-18 fluorodeoxyglucose positron emission tomography in the detection of silent metastases from malignant melanoma. Eur J Nucl Med 27:70–75. doi:10.​1007/​PL00006666 PubMedCrossRef
39.
Sica GT, Ji H, Ros PR (2000) CT and MR imaging of hepatic metastases. AJR Am J Roentgenol 174:691–698PubMedCrossRef
40.
41.
Vogl TJ, Schwarz W, Eichler K, et al. (2006) Hepatic intraarterial chemotherapy with gemcitabine in patients with unresectable cholangiocarcinomas and liver metastases of pancreatic cancer: a clinical study on maximum tolerable dose and treatment efficacy. J Cancer Res Clin Oncol 132:745–755. doi:10.​1007/​s00432-006-0138-0 PubMedCrossRef
42.
43.
Yagi H, Ueda M, Kawachi S, et al. (2004) Squamous cell carcinoma of the liver originating from non-parasitic cysts after a 15 year follow-up. Eur J Gastroenterol Hepatol 16:1051–1056PubMedCrossRef
44.
Yuki N, Hijikata Y, Kato M, et al. (2006) Squamous cell carcinoma as a rare entity of primary liver tumor with grave prognosis. Hepatol Res 36:322–327PubMedCrossRef
45.
Abbas R, Willis J, Kinsella T, et al. (2008) Primary squamous cell carcinoma of the main hepatic bile duct. Can J Surg 51:E85–E86PubMed
46.
Parwani AV, Chan TY, Mathew S, et al. (2004) Metastatic malignant melanoma in liver aspirate: cytomorphologic distinction from hepatocellular carcinoma. Diagn Cytopathol 30:247–250. doi:10.​1002/​dc.​10394 PubMedCrossRef
47.
48.
49.
50.
Pliskin A, Cualing H, Stenger RJ (1992) Primary squamous cell carcinoma originating in congenital cysts of the liver. Report of a case and review of the literature. Arch Pathol Lab Med 116:105–107PubMed
51.
52.
Doty JE, Tompkins RK (1989) Management of cystic disease of the liver. Surg Clin North Am 69:285–295PubMed
53.
54.
Bondini S, Leoni S, Bolondi L (2005) Squamous cell carcinoma of the liver: metastasis or primary neoplasm. J Clin Ultrasound 33:477–478PubMedCrossRef
55.
Boscolo G, Jirillo A, Da PP (2005) Complete remission of poorly differentiated squamous liver carcinoma after systemic chemotherapy and surgery. A case report. Tumori 91:71–72PubMed
56.
Kaji R, Sasaki N, Tateishi I, et al. (2003) A case report of primary hepatic squamous cell carcinoma that remarkably responded to low dose arterial injection of anti-cancer drugs. Kurume Med J 50:71–75PubMedCrossRef
57.
58.
Lao XM, Zhang YQ, Jin X, et al. (2006) Primary clear cell carcinoma of liver–clinicopathologic features and surgical results of 18 cases. Hepatogastroenterology 53:128–132PubMed
59.
60.
Buchanan TJ, Huvos AG (1974) Clear-cell carcinoma of the liver. A clinicopathologic study of 13 patients. Am J Clin Pathol 61:529–539PubMed
61.
62.
63.
64.
65.
66.
Ebara M, Ohto M, Watanabe Y, et al. (1986) Diagnosis of small hepatocellular carcinoma: correlation of MR imaging and tumor histologic studies. Radiology 159:371–377PubMed
67.
68.
Jeong YY, Yim NY, Kang HK (2005) Hepatocellular carcinoma in the cirrhotic liver with helical CT and MRI: imaging spectrum and pitfalls of cirrhosis-related nodules. AJR Am J Roentgenol 185:1024–1032. doi:10.​2214/​AJR.​04.​1096 PubMedCrossRef
69.
70.
Ye XP, Li LQ, Peng T, et al. (2010) Diagnosis and treatment of primary clear cell carcinoma of the liver. Zhonghua Zhong Liu Za Zhi 32:64–66PubMed
71.
Kindblom LG, Remotti HE, Aldenborg F, et al. (1998) Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. Am J Pathol 152:1259–1269PubMed
72.
Miettinen M, Lasota J (2006) Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis. Arch Pathol Lab Med 130:1466–1478PubMed
73.
Hu X, Forster J, Damjanov I (2003) Primary malignant gastrointestinal stromal tumor of the liver. Arch Pathol Lab Med 127:1606–1608PubMed
74.
De Chiara A, De Rosa V, Lastoria S, et al. (2006) Primary gastrointestinal stromal tumor of the liver with lung metastases successfully treated with STI-571 (imatinib mesylate). Front Biosci 11:498–501PubMedCrossRef
75.
DeMatteo RP, Shah A, Fong Y, et al. (2001) Results of hepatic resection for sarcoma metastatic to liver. Ann Surg 234(540–547):547–548
76.
Vanel D, Albiter M, Shapeero L, et al. (2005) Role of computed tomography in the follow-up of hepatic and peritoneal metastases of GIST under imatinib mesylate treatment: a prospective study of 54 patients. Eur J Radiol 54:118–123. doi:10.​1016/​j.​ejrad.​2005.​01.​012 PubMedCrossRef
77.
78.
DeMatteo RP, Lewis JJ, Leung D, et al. (2000) Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival. Ann Surg 231:51–58PubMedCrossRef
79.
Demetri GD, von Mehren M, Blanke CD, et al. (2002) Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 347:472–480PubMedCrossRef
80.
Miettinen M, Majidi M, Lasota J (2002) Pathology and diagnostic criteria of gastrointestinal stromal tumors (GISTs): a review. Eur J Cancer 38(Suppl 5):S39–S51PubMedCrossRef
81.
82.
Fiaschetti V, Fiori R, Gaspari E, et al. (2010) Mixed hepatoblastoma in a young male adult: a case report and literature review. Case Report Med 2010:919457. doi:10.​1155/​2010/​919457
83.
84.
85.
Meyers RL, Rowland JR, Krailo M, et al. (2009) Predictive power of pretreatment prognostic factors in children with hepatoblastoma: a report from the Children’s Oncology Group. Pediatr Blood Cancer 53:1016–1022. doi:10.​1002/​pbc.​22088 PubMedCrossRef
86.
87.
88.
89.
90.
91.
Sasaki F, Matsunaga T, Iwafuchi M, et al. (2002) Outcome of hepatoblastoma treated with the JPLT-1 (Japanese Study Group for Pediatric Liver Tumor) Protocol-1: a report from the Japanese Study Group for Pediatric Liver Tumor. J Pediatr Surg 37:851–856. doi:10.​1053/​jpsu.​2002.​32886 PubMedCrossRef
92.
93.
Li JP, Chu JP, Yang JY, et al. (2008) Preoperative transcatheter selective arterial chemoembolization in treatment of unresectable hepatoblastoma in infants and children. Cardiovasc Intervent Radiol 31:1117–1123. doi:10.​1007/​s00270-008-9373-x PubMedCrossRef
94.
95.
96.
Dejong CHC, Parks RW, Currie E, et al. (2002) Treatment of hepatic metastases of neuroendocrine malignancies: a 10-year experience. J R Coll Surg Edinb 47:495–499PubMed
97.
98.
99.
Soga J (2002) Primary hepatic endocrinomas (carcinoids and variant neoplasms). A statistical evaluation of 126 reported cases. J Exp Clin Cancer Res 21:457–468PubMed
100.
Takayasu K, Muramatsu Y, Sakamoto M, et al. (1992) Findings in primary hepatic carcinoid tumor: US, CT, MRI, and angiography. J Comput Assist Tomogr 16:99–102PubMedCrossRef
101.
102.
103.
Komatsuda T, Ishida H, Furukawa K, et al. (2005) Primary carcinoid tumor of the liver: report of a case with an emphasis on contrast-enhanced ultrasonographic findings. J Clin Ultrasound 33:302–304. doi:10.​1002/​jcu.​20132 PubMedCrossRef
104.
105.
Fujino K, Koito K, Sano S, et al. (1998) A primary hepatic carcinoid tumor: evaluation by computed tomography and magnetic resonance imaging. Radiat Med 16:371–373PubMed
106.
McCarthy SM, Stark DD, Moss AA, et al. (1984) Computed tomography of malignant carcinoid disease. J Comput Assist Tomogr 8:846–850PubMedCrossRef
107.
Paulson EK, McDermott VG, Keogan MT, et al. (1998) Carcinoid metastases to the liver: role of triple-phase helical CT. Radiology 206:143–150PubMed
108.
Maton PN, Miller DL, Doppman JL, et al. (1987) Role of selective angiography in the management of patients with Zollinger-Ellison syndrome. Gastroenterology 92:913–918PubMed
109.
110.
111.
Virani MJ, Jain S (2002) Primary intraspinal primitive neuroectodermal tumor (PNET): a rare occurrence. Neurol India 50:75–80112PubMed
112.
Hart MN, Earle KM (1973) Primitive neuroectodermal tumors of the brain in children. Cancer 32:890–897PubMedCrossRef
113.
Shah N, Roychoudhury A, Sarkar C (1995) Primitive neuroectodermal tumor of maxilla in an adult. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 80:683–686PubMedCrossRef
114.
Charney DA, Charney JM, Ghali VS, et al. (1996) Primitive neuroectodermal tumor of the myocardium: a case report, review of the literature, immunohistochemical, and ultrastructural study. Hum Pathol 27:1365–1369PubMedCrossRef
115.
Dehner LP (1986) Peripheral and central primitive neuroectodermal tumors. A nosologic concept seeking a consensus. Arch Pathol Lab Med 110:997–1005PubMed
116.
Hyun CB, Lee YR, Bemiller TA (2002) Metastatic peripheral primitive neuroectodermal tumor (PNET) masquerading as liver abscess: a case report of liver metastasis in orbital PNET. J Clin Gastroenterol 35:93–97PubMedCrossRef
117.
Chang CH, Ramirez N, Sakr WA (1989) Primitive neuroectodermal tumor of the brain associated with malignant rhabdoid tumor of the liver: a histologic, immunohistochemical, and electron microscopic study. Pediatr Pathol 9:307–319PubMedCrossRef
118.
119.
Nair N, Goyal V, Nair CN (1998) Uptake of Tc-99 m MDP by a primitive neuroectodermal tumor of the liver. Clin Nucl Med 23:548–549PubMedCrossRef
120.
121.
Dick EA, McHugh K, Kimber C, et al. (2001) Imaging of non-central nervous system primitive neuroectodermal tumours: diagnostic features and correlation with outcome. Clin Radiol 56:206–215PubMedCrossRef
122.
Sabate JM, Franquet T, Parellada JA, et al. (1994) Malignant neuroectodermal tumour of the chest wall (Askin tumour): CT and MR findings in eight patients. Clin Radiol 49:634–638PubMedCrossRef
123.
124.
125.
Mani S, Dutta D, De BK (2011) Rare Primitive Neuroectodermal Tumor (PNET) of Liver in a Young Woman. Gastrointest Cancer Res 4:111–113PubMed
126.
Singh AD, Husson M, Shields CL, et al. (1994) Primitive neuroectodermal tumor of the orbit. Arch Ophthalmol 112:217–221PubMedCrossRef
127.
128.
Yao JC, Pavel M, Phan AT, et al. (2011) Chromogranin A and Neuron-Specific Enolase as Prognostic Markers in Patients with Advanced pNET Treated with Everolimus. J Clin Endocrinol Metab . doi:10.​1210/​jc.​2011-0666 PubMed
129.
Jones JE, McGill T (1995) Peripheral primitive neuroectodermal tumors of the head and neck. Arch Otolaryngol Head Neck Surg 121:1392–1395PubMedCrossRef
130.
Metadaten
Titel
Rare hepatic malignant tumors: dynamic CT, MRI, and clinicopathologic features: with analysis of 54 cases and review of the literature
verfasst von
Yan Tan
En-hua Xiao
Publikationsdatum
01.06.2013
Verlag
Springer-Verlag
Erschienen in
Abdominal Radiology / Ausgabe 3/2013
Print ISSN: 2366-004X
Elektronische ISSN: 2366-0058
DOI
https://doi.org/10.1007/s00261-012-9918-y

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