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01.08.2011 | Original Article

UGT1A11/28 and 1/6 genotypes have no effects on the efficacy and toxicity of FOLFIRI in Japanese patients with advanced colorectal cancer

verfasst von: Yu Sunakawa, Wataru Ichikawa, Ken-ichi Fujita, Fumio Nagashima, Hiroo Ishida, Keishi Yamashita, Keiko Mizuno, Keisuke Miwa, Kaori Kawara, Yuko Akiyama, Kazuhiro Araki, Wataru Yamamoto, Toshimichi Miya, Masaru Narabayashi, Yuichi Ando, Takashi Hirose, Shigehira Saji, Yasutsuna Sasaki

Erschienen in: Cancer Chemotherapy and Pharmacology | Ausgabe 2/2011

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Abstract

Purpose

Differences in efficacy and toxicity between UDP-glucuronosyltransferase (UGT) 1A1*1/*1 and *1/*6 or *1/*28 genotypes remain unclear in Japanese patients.

Methods

Patients with advanced colorectal cancer who received irinotecan combined with 5-fluorouracil plus l-leucovorin (FOLFIRI) as first-line therapy were divided into two groups: those with UGT1A1*1/*1 genotype and those with UGT1A1*1/*6 or *1/*28 genotype. Efficacy and toxicity were compared between these groups retrospectively.

Results

Forty-two patients (24 *1/*1 and 18 *1/*6 or *1/*28) were evaluated. The response rate was 48% in *1/*1 group and 56% in *1/*6 or *1/*28 group (P = 0.847). Median progression-free survival was 8.6 months in *1/*1 group and 8.5 months in *1/*6 or *1/*28 group (P = 0.888). No hematologic or non-hematologic toxic effects were clearly related to UGT1A1*1/*6 or *1/*28 during the first cycle or throughout the entire course of chemotherapy.

Conclusions

There were no significant differences in the efficacy or toxicity of FOLFIRI between patients with UGT1A1*1/*1 genotype and those with UGT1A1*1/*6 or *1/*28 genotype. Our results suggest that patients with the latter genotypes can receive FOLFIRI at the same dose of irinotecan as those with the UGT1A1*1/*1 genotype receive.

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Titel: UGT1A1*1/*28 and *1/*6 genotypes have no effects on the efficacy and toxicity of FOLFIRI in Japanese patients with advanced colorectal cancer
verfasst von: Yu Sunakawa
Wataru Ichikawa
Ken-ichi Fujita
Fumio Nagashima
Hiroo Ishida
Keishi Yamashita
Keiko Mizuno
Keisuke Miwa
Kaori Kawara
Yuko Akiyama
Kazuhiro Araki
Wataru Yamamoto
Toshimichi Miya
Masaru Narabayashi
Yuichi Ando
Takashi Hirose
Shigehira Saji
Yasutsuna Sasaki
Publikationsdatum: 01.08.2011
Verlag: Springer-Verlag
Erschienen in: Cancer Chemotherapy and Pharmacology / Ausgabe 2/2011
Print ISSN: 0344-5704
Elektronische ISSN: 1432-0843
DOI: https://doi.org/10.1007/s00280-010-1485-8

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UGT1A11/28 and 1/6 genotypes have no effects on the efficacy and toxicity of FOLFIRI in Japanese patients with advanced colorectal cancer