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Seminars in Immunopathology

Erschienen in:

15.04.2016 | Review

TRP functions in the broncho-pulmonary system

verfasst von: Francesco De Logu, Riccardo Patacchini, Giovanni Fontana, Pierangelo Geppetti

Erschienen in: Seminars in Immunopathology | Ausgabe 3/2016

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Abstract

The current understanding of the role of transient receptor potential (TRP) channels in the airways and lung was initially based on the localization of a series of such channels in a subset of sensory nerve fibers of the respiratory tract. Soon after, TRP channel expression and function have been identified in respiratory nonneuronal cells. In these two locations, TRPs regulate physiological processes aimed at integrating different stimuli to maintain homeostasis and to react to harmful agents and tissue injury by building up inflammatory responses and repair processes. There is no doubt that TRPs localized in the sensory network contribute to airway neurogenic inflammation, and emerging evidence underlines the role of nonneuronal TRPs in orchestrating inflammation and repair in the respiratory tract. However, recent basic and clinical studies have offered clues regarding the contribution of neuronal and nonneuronal TRPs in the mechanism of asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, cough, and other respiratory diseases.

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Titel: TRP functions in the broncho-pulmonary system
verfasst von: Francesco De Logu
Riccardo Patacchini
Giovanni Fontana
Pierangelo Geppetti
Publikationsdatum: 15.04.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Seminars in Immunopathology / Ausgabe 3/2016
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-016-0557-1

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