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01.10.2011 | Gastrointestinal

The uptake transporter OATP8 expression decreases during multistep hepatocarcinogenesis: correlation with gadoxetic acid enhanced MR imaging

verfasst von: Azusa Kitao, Osamu Matsui, Norihide Yoneda, Kazuto Kozaka, Rieko Shinmura, Wataru Koda, Satoshi Kobayashi, Toshifumi Gabata, Yoh Zen, Tatsuya Yamashita, Shuichi Kaneko, Yasuni Nakanuma

Erschienen in: European Radiology | Ausgabe 10/2011

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Abstract

Objectives

To clarify the changes in organic anion-transporting polypeptide 8 (OATP8) expression and enhancement ratio on gadoxetic acid-enhanced MR imaging in hepatocellular nodules during multistep hepatocarcinogenesis.

Methods

In imaging analysis, we focused on 71 surgically resected hepatocellular carcinomas (well, moderately and poorly differentiated HCCs) and 1 dysplastic nodule (DN). We examined the enhancement ratio in the hepatobiliary phase of gadoxetic acid enhanced MR imaging [(1/postcontrast T1 value−1/precontrast T1 value)/(1/precontrast T1 value)], then analysed the correlation among the enhancement ratio, tumour differentiation grade and intensity of immunohistochemical OATP8 expression. In pathological analysis, we focused on surgically resected 190 hepatocellular nodules: low-grade DNs, high-grade DNs, early HCCs, well-differentiated, moderately differentiated and poorly differentiated HCCs, including cases without gadoxetic acid-enhanced MR imaging. We evaluated the correlation between the immunohistochemical OATP8 expression and the tumour differentiation grade.

Results

The enhancement ratio of HCCs decreased in accordance with the decline in tumour differentiation (P < 0.0001, R = 0.28) and with the decline of OATP8 expression (P < 0.0001, R = 0.81). The immunohistochemical OATP8 expression decreased from low-grade DNs to poorly differentiated HCCs (P < 0.0001, R = 0.15).

Conclusions

The immunohistochemical expression of OATP8 significantly decreases during multistep hepatocarcinogenesis, which may explain the decrease in enhancement ratio on gadoxetic acid-enhanced MR imaging.

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Titel: The uptake transporter OATP8 expression decreases during multistep hepatocarcinogenesis: correlation with gadoxetic acid enhanced MR imaging
verfasst von: Azusa Kitao
Osamu Matsui
Norihide Yoneda
Kazuto Kozaka
Rieko Shinmura
Wataru Koda
Satoshi Kobayashi
Toshifumi Gabata
Yoh Zen
Tatsuya Yamashita
Shuichi Kaneko
Yasuni Nakanuma
Publikationsdatum: 01.10.2011
Verlag: Springer-Verlag
Erschienen in: European Radiology / Ausgabe 10/2011
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-011-2165-8

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The uptake transporter OATP8 expression decreases during multistep hepatocarcinogenesis: correlation with gadoxetic acid enhanced MR imaging