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01.06.2013 | Breast

Correlation of contrast agent kinetics between iodinated contrast-enhanced spectral tomosynthesis and gadolinium-enhanced MRI of breast lesions

verfasst von: Vera Froeling, Felix Diekmann, Diane M. Renz, Eva M. Fallenberg, Ingo G. Steffen, Susanne Diekmann, Rüdiger Lawaczeck, Florian F. Schmitzberger

Erschienen in: European Radiology | Ausgabe 6/2013

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Abstract

Objectives

Assessment of contrast agent kinetics in contrast-enhanced MRI (CE-MRI) with gadolinium-containing contrast agents offers the opportunity to predict breast lesion malignancy. The goal of our study was to determine if similar patterns exist for spectral contrast-enhanced digital breast tomosynthesis (CE-DBT) using an iodinated contrast agent.

Methods

The protocol of our prospective study was approved by the relevant institutional review board and the German Federal Office for Radiation Protection. All patients provided written informed consent. We included 21 women with a mean age of 62.4 years. All underwent ultrasound-guided biopsy of a suspect breast lesion, spectral CE-DBT and CE-MRI. For every breast lesion, contrast agent kinetics was assessed by signal intensity–time curves for spectral CE-DBT and CE-MRI. Statistical comparison used Cohen’s kappa and Spearman’s rho test.

Results

Spearman’s rho of 0.49 showed significant (P = 0.036) correlation regarding the contrast agent kinetics in signal intensity–time curves for spectral CE-DBT and CE-MRI. Cohen’s kappa indicated moderate agreement (kappa = 0.438).

Conclusion

There is a statistically significant correlation between contrast agent kinetics in the signal intensity–time curves for spectral CE-DBT and CE-MRI. Observing intralesional contrast agent kinetics in spectral CE-DBT may aid evaluation of malignant breast lesions.

Key Points

• Contrast agent kinetics can be assessed using spectral digital breast tomosynthesis (DBT).

• Contrast agent kinetics patterns in spectral DBT are similar to those in contrast-enhanced MRI.

• Multiple contrast enhancement for spectral DBT gives additional diagnostic information.

Carney PA, Miglioretti DL, Yankaskas BC et al (2003) Individual and combined effects of age, breast density, and hormone replacement therapy use on the accuracy of screening mammography. Ann Intern Med 138:168–175PubMedCrossRef

Förnvik D, Zackrisson S, Ljungberg O et al (2010) Breast tomosynthesis: accuracy of tumor measurement compared with digital mammography and ultrasonography. Acta Radiol 51:240–247PubMedCrossRef

Andersson I, Ikeda DM, Zackrisson S et al (2008) Breast tomosynthesis and digital mammography: a comparison of breast cancer visibility and BIRADS classification in a population of cancers with subtle mammographic findings. Eur Radiol 18:2817–2825PubMedCrossRef

Hellerhoff K (2010) Digital breast tomosynthesis: technical principles, current clinical relevance and future perspectives. Radiologe 50:991–998PubMedCrossRef

Tingberg A (2010) X-ray tomosynthesis: a review of its use for breast and chest imaging. Radiat Prot Dosim 139:100–107CrossRef

Lewin JM, Niklason L (2007) Advanced applications of digital mammography: tomosynthesis and contrast-enhanced digital mammography. Semin Roentgenol 42:243–252PubMedCrossRef

Lee SH, Kim JH, Cho N et al (2010) Multilevel analysis of spatiotemporal association features for differentiation of tumor enhancement patterns in breast DCE-MRI. Med Phys 37:3940–3956PubMedCrossRef

Yamamoto A, Fukushima H, Okamura R et al (2006) Dynamic helical CT mammography of breast cancer. Radiat Med 24:35–40PubMedCrossRef

Prionas ND, Lindfors KK, Ray S et al (2010) Contrast-enhanced dedicated breast CT: initial clinical experience. Radiology 256:714–723PubMedCrossRef

10.

Diekmann F, Diekmann S, Jeunehomme F, Muller S, Hamm B, Bick U (2005) Digital mammography using iodine-based contrast media: initial clinical experience with dynamic contrast medium enhancement. Investig Radiol 40:397–404CrossRef

11.

Dromain C, Balleyguier C, Adler G, Garbay JR, Delaloge S (2009) Contrast-enhanced digital mammography. Eur J Radiol 69:34–42PubMedCrossRef

12.

Dromain C, Balleyguier C, Muller S et al (2006) Evaluation of tumor angiogenesis of breast carcinoma using contrast-enhanced digital mammography. Am J Roentgenol 187:528–537CrossRef

13.

Jong RA, Yaffe MJ, Skarpathiotakis M et al (2003) Contrast-enhanced digital mammography: initial clinical experience. Radiology 228:842–850PubMedCrossRef

14.

Schmitzberger FF, Fallenberg EM, Lawaczeck R et al (2011) Development of low-dose photon-counting contrast-enhanced tomosynthesis with spectral imaging. Radiology 259:558–564PubMedCrossRef

15.

Baltzer PA, Benndorf M, Gajda M, Kaiser WA (2010) An exception to tumour neoangiogenesis in a malignant breast-lesion. Breast J 16:197–198PubMedCrossRef

16.

Kuhl CK, Mielcareck P, Klaschik S et al (1999) Dynamic breast MR imaging: are signal intensity time course data useful for differential diagnosis of enhancing lesions? Radiology 211:101–110PubMed

17.

Kuhl CK, Jost P, Morakkabati N, Zivanovic O, Schild HH, Gieseke J (2006) Contrast-enhanced MR imaging of the breast at 3.0 and 1.5 T in the same patients: initial experience. Radiology 239:666–676PubMedCrossRef

18.

Nunes LW, Englander SA, Charafeddine R, Schnall MD (2002) Optimal post-contrast timing of breast MR image acquisition for architectural feature analysis. J Magn Reson Imaging 16:42–50PubMedCrossRef

19.

Hylton NM (2001) Vascularity assessment of breast lesions with gadolinium-enhanced MR imaging. Magn Reson Imaging Clin N Am 9:321–332PubMed

20.

Carton AK, Gavenonis SC, Currivan JA, Conant EF, Schnall MD, Maidment AD (2010) Dual-energy contrast-enhanced digital breast tomosynthesis–a feasibility study. Br J Radiol 83:344–350PubMedCrossRef

21.

Fredenberg E et al (2010) Energy resolution of a photon- counting silicon strip detector. Nucl Instrum Methods Phys Res A 613:156–162CrossRef

22.

Lawaczeck R, Jost G, Pietsch H (2011) Pharmacokinetics of contrast media in humans: model with circulation, distribution, and renal excretion. Investig Radiol 46:576–585CrossRef

23.

Landis JR, Koch GG (1977) The measurement of observer agreement for categorical data. Biometrics 1:159–174CrossRef

24.

Gur D, Abrams GS, Chough DM et al (2009) Digital breast tomosynthesis: observer performance study. AJR Am J Roentgenol 193:586–591PubMedCrossRef

Titel: Correlation of contrast agent kinetics between iodinated contrast-enhanced spectral tomosynthesis and gadolinium-enhanced MRI of breast lesions
verfasst von: Vera Froeling
Felix Diekmann
Diane M. Renz
Eva M. Fallenberg
Ingo G. Steffen
Susanne Diekmann
Rüdiger Lawaczeck
Florian F. Schmitzberger
Publikationsdatum: 01.06.2013
Verlag: Springer-Verlag
Erschienen in: European Radiology / Ausgabe 6/2013
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-012-2742-5

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Correlation of contrast agent kinetics between iodinated contrast-enhanced spectral tomosynthesis and gadolinium-enhanced MRI of breast lesions