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Archives of Gynecology and Obstetrics

Erschienen in:

01.04.2010 | Reproductive Medicine

Comparison of mild stimulation and conventional stimulation in ART outcome

verfasst von: Mohammad Ali Karimzadeh, Shahnaz Ahmadi, Homa Oskouian, Elham Rahmani

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 4/2010

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Abstract

Purpose

To provide a treatment for particular condition that is the most effective treatment with the least risk and cost for the patient we compared the efficacy of using clomiphene 100 mg + delayed low dose gonadotropin + flexible GnRH antagonist administration for ovarian stimulation protocol and GnRH agonist + gonadotropin for stimulation protocol in IVF outcome.

Methods

Clinical outcome of 243 women with regularly menstruation who were candidate for IVF. They had undergone stimulation with GnRH agonist and gonadotropin (group A) or clomiphene citrate, gonadotropin and GnRH antagonist (group B). Main outcome was ongoing pregnancy.

Results

There were no significant difference in mean age, cause of infertility, basal FSH, BMI, duration of infertility, endometrial thickness on the day HCG administration in two groups. The number of recovered oocytes, obtained embryos, transferred embryos, peak of estradiol on the day HCG administration and OHSS were significantly higher in group A. Significantly more patients in control group had embryos for cryopreservation. There were no significant difference in clinical pregnancy rate and ongoing pregnancy rate between two groups.

Conclusion

Clomiphene + delayed low dose gonadotropin + flexible GnRH − antagonist stimulation is an acceptable alternative protocol for IVF in patients with regularly menstruation.

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Titel: Comparison of mild stimulation and conventional stimulation in ART outcome
verfasst von: Mohammad Ali Karimzadeh
Shahnaz Ahmadi
Homa Oskouian
Elham Rahmani
Publikationsdatum: 01.04.2010
Verlag: Springer-Verlag
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 4/2010
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-009-1252-4

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Comparison of mild stimulation and conventional stimulation in ART outcome

Abstract

Purpose

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Conclusion

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