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25.05.2019 | Original Communication

Cerebrospinal fluid neurofilament light chain tracks cognitive impairment in multiple sclerosis

verfasst von: Lorenzo Gaetani, Nicola Salvadori, Viviana Lisetti, Paolo Eusebi, Andrea Mancini, Lucia Gentili, Angela Borrelli, Emilio Portaccio, Paola Sarchielli, Kaj Blennow, Henrik Zetterberg, Lucilla Parnetti, Paolo Calabresi, Massimiliano Di Filippo

Erschienen in: Journal of Neurology | Ausgabe 9/2019

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Abstract

Background

Cognitive impairment (CI) is a disabling symptom of multiple sclerosis (MS). Axonal damage disrupts neural circuits and may play a role in determining CI, but its detection and monitoring are not routinely performed. Cerebrospinal fluid (CSF) neurofilament light chain (NfL) is a promising marker of axonal damage in MS.

Objective

To retrospectively examine the relationship between CSF NfL and CI in MS patients.

Methods

CSF NfL concentration was measured in 28 consecutive newly diagnosed MS patients who underwent a neuropsychological evaluation with the Brief Repeatable Battery of Neuropsychological tests (BRBN).

Results

CSF NfL was higher in patients with overall CI (947.8 ± 400.7 vs 518.4 ± 424.7 pg/mL, p < 0.01), and with impairment in information processing speed (IPS) (820.8 ± 413.6 vs 513.6 ± 461.4 pg/mL, p < 0.05) and verbal fluency (1292 ± 511 vs 582.8 ± 395.4 pg/mL, p < 0.05), and it positively correlated with the number of impaired BRBN tests (r = 0.48, p = 0.01) and cognitive domains (r = 0.47, p = 0.01). Multivariate analyses taking into account potential confounders confirmed these findings.

Conclusion

CSF NfL is higher in MS patients with CI and impaired IPS and verbal fluency. Large myelinated axons injury, causing neural disconnection, may be an important determinant of CI in MS and can be reliably measured through CSF NfL.

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Titel: Cerebrospinal fluid neurofilament light chain tracks cognitive impairment in multiple sclerosis
verfasst von: Lorenzo Gaetani
Nicola Salvadori
Viviana Lisetti
Paolo Eusebi
Andrea Mancini
Lucia Gentili
Angela Borrelli
Emilio Portaccio
Paola Sarchielli
Kaj Blennow
Henrik Zetterberg
Lucilla Parnetti
Paolo Calabresi
Massimiliano Di Filippo
Publikationsdatum: 25.05.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Neurology / Ausgabe 9/2019
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-019-09398-7

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Abstract

Background

Objective

Methods

Results

Conclusion

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