Background
Methods
Data source
Study cohort
Case definition
Main outcomes
Statistical methods
Data accessibility and ethics
Results
Incidence of epilepsy in pre-pubertal children
Age of epilepsy onset | Female (n = 69,253) | Male (n = 73,310) | Total (n = 142,563) | |||
---|---|---|---|---|---|---|
Number of initial diagnoses | Incidence rate per 100,000 (95% CI) | Number of initial diagnoses | Incidence rate per 100,000 (95% CI) | Number of initial diagnoses | Incidence rate per 100,000 (95% CI) | |
< 1 | 132 | 191 (161, 226) | 158 | 216 (184, 252) | 290 | 203 (181, 228) |
1 | 231 | 334 (293, 379) | 216 | 295 (258, 337) | 447 | 314 (286, 344) |
2 | 143 | 206 (175, 243) | 184 | 251 (217, 290) | 327 | 229 (206, 256) |
3 | 109 | 157 (130, 190) | 134 | 183 (154, 217) | 243 | 170 (150, 193) |
4 | 104 | 150 (124, 182) | 131 | 179 (151, 212) | 235 | 165 (145, 187) |
5 | 107 | 155 (128, 187) | 116 | 158 (132, 190) | 223 | 156 (137, 178) |
6 | 83 | 120 (97, 149) | 100 | 136 (112, 166) | 183 | 128 (111, 148) |
7 | 84 | 121 (98, 150) | 108 | 147 (122, 178) | 192 | 135 (117, 155) |
8 | 71 | 103 (81, 129) | 89 | 121 (99, 149) | 160 | 112 (96, 131) |
9 | 100 | 144 (119, 176) | 138 | 188 (159, 222) | 238 | 167 (147, 190) |
10 | 80 | 116 (93, 144) | 110 | 150 (124, 181) | 190 | 133 (116, 154) |
Prevalence and the risk of cognitive impairment in children with epilepsy
Age at onset of cognitive impairment | Cases | Controls | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Female (n = 1244) | Male (n = 1484) | Total (n = 2728) | Female (n = 68,009) | Male (n = 71,826) | Total (n = 139,835) | |||||||
Number of initial diagnoses | Incidence rate per 10,000 (95% CI) | Number of initial diagnoses | Incidence rate per 10,000 (95% CI) | Number of initial diagnoses | Incidence rate per 10,000 (95% CI) | Number of initial diagnoses | Incidence rate per 10,000 (95% CI) | Number of initial diagnoses | Incidence rate per 10,000 (95% CI) | Number of initial diagnoses | Incidence rate per 10,000 (95% CI) | |
< 1 | 4 | 322 (93, 856) | 9 | 606 (300, 1168) | 13 | 477 (270, 823) | 34 | 50 (36, 70) | 34 | 47 (34, 66) | 68 | 49 (38, 62) |
1 | 17 | 1367 (838, 2194) | 25 | 1685 (1132, 2487) | 42 | 1540 (1136, 2079) | 55 | 81 (62, 105) | 70 | 97 (77, 123) | 125 | 89 (75, 107) |
2 | 20 | 1608 (1028, 2486) | 38 | 2561 (1862, 3504) | 58 | 2126 (1644, 2743) | 63 | 93 (72, 119) | 69 | 96 (76, 122) | 132 | 94 (80, 112) |
3 | 21 | 1688 (1092, 2582) | 19 | 1280 (808, 2004) | 40 | 1466 (1074, 1995) | 60 | 88 (68, 114) | 94 | 131 (107, 160) | 154 | 110 (94, 129) |
4 | 24 | 1929 (1286, 2869) | 28 | 1887 (1298, 2724) | 52 | 1906 (1452, 2495) | 94 | 138 (113, 169) | 187 | 260 (226, 300) | 281 | 201 (179, 226) |
5 | 22 | 1768 (1156, 2678) | 34 | 2291 (1634, 3194) | 56 | 2053 (1580, 2660) | 93 | 137 (112, 168) | 210 | 292 (255, 335) | 303 | 217 (194, 242) |
6 | 16 | 1286 (776, 2096) | 30 | 2022 (1409, 2882) | 46 | 1686 (1262, 2246) | 80 | 118 (94, 147) | 166 | 231 (198, 269) | 246 | 176 (155, 199) |
7 | 28 | 2251 (1549, 3247) | 31 | 2089 (1465, 2960) | 59 | 2163 (1676, 2784) | 73 | 107 (85, 135) | 153 | 213 (182, 250) | 226 | 162 (142, 184) |
8 | 15 | 1206 (714, 1998) | 27 | 1819 (1242, 2645) | 42 | 1540 (1136, 2079) | 92 | 135 (110, 166) | 160 | 223 (191, 260) | 252 | 180 (159, 204) |
9 | 14 | 1125 (653, 1899) | 22 | 1482 (969, 2247) | 36 | 1320 (949, 1827) | 92 | 135 (110, 166) | 189 | 263 (228, 303) | 281 | 201 (179, 226) |
10 | 12 | 965 (533, 1698) | 19 | 1280 (808, 2004) | 31 | 1136 (796, 1614) | 86 | 126 (102, 156) | 155 | 216 (184, 253) | 241 | 172 (152, 196) |