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Graefe's Archive for Clinical and Experimental Ophthalmology

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24.08.2016 | Cataract

Intracameral cefuroxime in the prevention of postoperative endophthalmitis: an experience from Hong Kong

verfasst von: Alex Lap-Ki Ng, Wilson Wai-Tat Tang, Patrick Siu-Hung Li, Kenneth Kai-Wang Li

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 10/2016

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Abstract

Purpose

The purpose was to study the effect of introducing intracameral cefuroxime, which was compounded by a hospital pharmacy, on postoperative endophthalmitis in a tertiary eye centre in Hong Kong.

Methods

All cases that underwent cataract surgeries over a 12-year period (January 2004 to December 2015) were included. The routine use of intracameral cefuroxime at the end of cataract surgery was introduced at our centre after April 2010. All cefuroxime aliquots were prepared by the hospital pharmacy using an aseptic compounding technique. The rates of postoperative endophthalmitis before April 2010 (Group 1, no intracameral cefuroxime) and after April 2010 (Group 2, routine use of intracameral cefuroxime) were compared.

Results

A total of 30,428 eyes (7,332 in Group 1 and 23,096 in Group 2) were studied. Eight cases developed postoperative endophthalmitis (1.09 in 1000; 0.11 %) in Group 1 whereas no cases developed endophthalmitis (0 %) in Group 2. The rate of reduction was statistically significant (p < 0.0001). Seven out of eight cases of endophthalmitis were confirmed by positive culture. Organisms identified were Group G Streptococcus (two cases), Group B Streptococcus, Staphylococcus aureus, Serratia marcescens, and coagulase-negative Staphylococcus (two cases). Antibiotic susceptibility testing results were available in six cases. Four out of six organisms were susceptible to the penicillin group. No adverse events related to the use of intracameral cefuroxime were encountered.

Conclusions

The use of intracameral cefuroxime could significantly reduce the rate of postoperative endophthalmitis in a tertiary centre in Hong Kong. The use of aseptic compounding to prepare cefuroxime aliquots by hospital pharmacy appeared to be safe and efficacious.

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Titel: Intracameral cefuroxime in the prevention of postoperative endophthalmitis: an experience from Hong Kong
verfasst von: Alex Lap-Ki Ng
Wilson Wai-Tat Tang
Patrick Siu-Hung Li
Kenneth Kai-Wang Li
Publikationsdatum: 24.08.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 10/2016
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-016-3473-0

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