nach oben

Erschienen in:

01.04.2005 | Original Article

Amplification of NOTCH1 and ABL1 gene loci is a frequent aberration in enteropathy-type T-cell lymphoma

verfasst von: Pavlina Cejkova, Andreas Zettl, Anne K. Baumgärtner, Andreas Chott, German Ott, Hans Konrad Müller-Hermelink, Petr Starostik

Erschienen in: Virchows Archiv | Ausgabe 4/2005

Einloggen, um Zugang zu erhalten

Abstract

We have shown previously that amplification of chromosomal region 9q34 is the most frequent aberration in enteropathy-type T-cell lymphoma (ETL). To determine the minimum amplified 9q34 region and identify possible candidate gene(s), we performed a detailed microsatellite screening and quantitative real-time PCR (QPCR) on 26 ETL cases. Microsatellite analysis revealed allelic imbalance in both ABL1 and NOTCH1 gene loci (microsatellites D9S290–D9S1847 and D9S158 flanking the former and latter genes, respectively) localized in the band 9q34. The results were confirmed by TaqMan-based QPCR showing amplification of ABL1 and NOTCH1 exons in 50% and 65% of cases, respectively. Amplifications of the NOTCH1 gene were more frequent than of the ABL1 gene; moreover, the analyzed NOTCH1 exon consistently displayed higher levels of amplification than ABL1 coding sequences. From 9q34 known genes, NOTCH1 could thus be the primary target of genomic DNA amplification in ETL.

Aster JC, Xu L, Karnell FG et al (2000) Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by notch1. Mol Cell Biol 20:7505–7515

Baumgartner AK, Zettl A, Chott A et al (2003) High frequency of genetic aberrations in enteropathy-type T-cell lymphoma. Lab Invest 83:1509–1516

Bush G, diSibio G, Miyamoto A et al (2001) Ligand-induced signaling in the absence of furin processing of Notch1. Dev Biol 229:494–502

Carbonnel F, Lavergne A, Messing B et al (1994) Extensive small enteropathy-type T-cell lymphoma of low-grade malignancy associated with a new chromosomal translocation. Cancer 73:1286–1291

Collins SJ, Groudine MT (1983) Rearrangement and amplification of c-abl sequences in the human chronic myelogenous leukemia cell line K-562. Proc Natl Acad Sci U S A 80:4813–4817

De Klein A, van Kessel AG, Grosveld G et al (1982) A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia. Nature 300:765–767

De Klein A, Hagemeijer A, Bartram CR et al (1986) bcr rearrangement and translocation of the c-abl oncogene in Philadelphia positive acute lymphoblastic leukemia. Blood 68:1369–1375

Deftos ML, Bevan MJ (2000) Notch signaling in T cell development. Curr Opin Immunol 12:166–172

Ellisen LW, Bird J, West DC et al (1991) TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66:649–661

10.

Ferguson A, Kingstone K (1996) Coeliac disease and malignancies. Acta Paediatr Suppl 412:78–81

11.

Golub TR, Goga A, Barker GF et al (1996) Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia. Mol Cell Biol 16:4107–4116

12.

Graux C, Cools J, Melotte C et al (2004) Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia. Nat Genet 36:1084–1089

13.

Howell WM, Leung ST, Jones DB et al (1995) HLA-DRB, -DQA, and -DQB polymorphism in celiac disease and enteropathy-associated T-cell lymphoma. Common features and additional risk factors for malignancy. Hum Immunol 43:29–37

14.

Iso T (2001) HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling. Mol Cell Biol 21:6080–6089CrossRefPubMed

15.

Jaffe ES, Harris NL, Stein H et al (2001) Pathology and genetics of tumours of haematopoietic and lymphoid tissues. World Health Organization classification of tumours. IARC Press, Lyon, pp 157–160

16.

Jaiswal S, Traver D, Miyamoto T et al (2003) Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias. Proc Natl Acad Sci U S A 100:10002–10007

17.

Jundt F, Anagnostopoulos I, Forster R et al (2002) Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma. Blood 99:3398–3403

18.

Kenner L, Beham-Schmid C, Kerbl R et al (1999) ABL amplification in a patient with lymphoid blast crisis of chronic myelogenous leukaemia. Virchows Arch 434:255–257

19.

Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402–408CrossRefPubMed

20.

Morimura T, Goitsuka R, Zhang Y et al (2000) Cell cycle arrest and apoptosis induced by Notch1 in B cells. J Biol Chem 275:36523–36531

21.

Nair P, Somasundaram K, Krishna S (2003) Activated Notch1 inhibits p53-induced apoptosis and sustains transformation by human papillomavirus type 16 E6 and E7 oncogenes through a PI3K-PKB/Akt-dependent pathway. J Virol 77:7106–7112

22.

Nakagawa O (2000) Members of the HRT family of basic helix–loop–helix proteins act as transcriptional repressors downstream of Notch signaling. Proc Natl Acad Sci U S A 97:13655–13660

23.

Ordentlich P, Lin A, Shen CP et al (1998) Notch inhibition of E47 supports the existence of a novel signaling pathway. Mol Cell Biol 18:2230–2239

24.

Ott G, Katzenberger T, Siebert R et al (1998) Chromosomal abnormalities in nodal and extranodal CD30+ anaplastic large cell lymphomas: infrequent detection of the t(2;5) in extranodal lymphomas. Genes Chromosomes Cancer 22:114–121

25.

Pear WS, Aster JC, Scott ML et al (1996) Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J Exp Med 183:2283–2291

26.

Sade H, Krishna S, Sarin A (2004) The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cells. J Biol Chem 279:2937–2944

27.

Skorski T, Bellacosa A, Nieborowska-Skorska M et al (1997) Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway. EMBO J 16:6151–6161

28.

Tanaka K, Arif M, Eguchi M et al (1997) Frequent jumping translocations of chromosomal segments involving the ABL oncogene alone or in combination with CD3-MLL genes in secondary leukemias. Blood 89:596–600

29.

Trainor KJ, Brisco MJ, Wan JH et al (1991) Gene rearrangement in B- and T-lymphoproliferative disease detected by the polymerase chain reaction. Blood 78:192–196

30.

Wright DH, Jones DB, Clark H et al (1991) Is adult-onset coeliac disease due to a low-grade lymphoma of intraepithelial T lymphocytes? Lancet 337:1373–1374

31.

Xie S, Wang Y, Liu J et al (2001) Involvement of Jak2 tyrosine phosphorylation in Bcr–Abl transformation. Oncogene 20:6188–6195

32.

Zettl A, Ott G, Makulik A et al (2002) Chromosomal gains at 9q characterize enteropathy-type T-cell lymphoma. Am J Pathol 161:1635–1645

Titel: Amplification of NOTCH1 and ABL1 gene loci is a frequent aberration in enteropathy-type T-cell lymphoma
verfasst von: Pavlina Cejkova
Andreas Zettl
Anne K. Baumgärtner
Andreas Chott
German Ott
Hans Konrad Müller-Hermelink
Petr Starostik
Publikationsdatum: 01.04.2005
Verlag: Springer-Verlag
Erschienen in: Virchows Archiv / Ausgabe 4/2005
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-005-1214-6

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Amplification of NOTCH1 and ABL1 gene loci is a frequent aberration in enteropathy-type T-cell lymphoma

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2005

CD2-associated protein in human urogenital system and in adult kidney tumours

Benign Müllerian inclusions coexisting with breast metastatic carcinoma in an axillary lymph node

Chromophobe renal cell carcinoma with microcystic and adenomatous arrangement and pigmentation—a diagnostic pitfall. Morphological, immunohistochemical, ultrastructural and molecular genetic report of 20 cases

Dedifferentiated liposarcoma of the oral cavity with angiosarcomatous dedifferentiation

Changes in the adherens junctions of human endothelial cells infected with spotted fever group rickettsiae

Immunohistochemical localization of subtilisin/kexin-like proprotein convertases in human atherosclerosis

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie