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Virchows Archiv

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22.06.2017 | Original Article

Neuron navigator-2 and cyclin D2 are new candidate prognostic markers in uterine sarcoma

verfasst von: Ben Davidson, Ellen Hellesylt, Arild Holth, Håvard Emil Danielsen, Tone Skeie-Jensen, Betina Katz

Erschienen in: Virchows Archiv | Ausgabe 3/2017

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Abstract

The objective of this study was to validate the diagnostic and clinical role of four protein products of genes previously found to be differentially expressed in uterine low-grade endometrial stromal sarcoma (LG-ESS) compared to uterine leiomyosarcoma (LMS). Protein expression by immunohistochemistry of transgelin (TGLN), neuron navigator-2 (NAV2), fatty acid binding protein-3 (FABP3), and cyclin D2 (CCND2) was analyzed in 305 uterine sarcomas (231 LMS, 74 LG-ESS). Expression was analyzed for association with clinicopathologic parameters and survival. TGLN (p < 0.001), NAV2 (p < 0.001), and FABP3 (p = 0.005) were overexpressed in LMS compared to LG-ESS, whereas nuclear CCND2 (p < 0.001) was overexpressed in LG-ESS. NAV2 expression was associated with shorter overall survival in patients with LMS (p = 0.037), whereas nuclear CCND2 expression in LG-ESS was significantly related to longer survival (p = 0.012) in univariate analysis. Nuclear CCND2 expression was an independent prognosticator in Cox multivariate analysis (p = 0.023). In conclusion, TGLN, FABP3, NAV2, and nuclear CCND2 aid in differentiating LG-ESS from LMS. NAV2 and CCND2 are novel candidate prognostic markers in LMS and LG-ESS, respectively.

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Titel: Neuron navigator-2 and cyclin D2 are new candidate prognostic markers in uterine sarcoma
verfasst von: Ben Davidson
Ellen Hellesylt
Arild Holth
Håvard Emil Danielsen
Tone Skeie-Jensen
Betina Katz
Publikationsdatum: 22.06.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Virchows Archiv / Ausgabe 3/2017
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-017-2172-5

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Neuron navigator-2 and cyclin D2 are new candidate prognostic markers in uterine sarcoma

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

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