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01.12.2017 | Original Article

Cortical and subcortical connections of parietal and premotor nodes of the monkey hand mirror neuron network

verfasst von: Stefania Bruni, Marzio Gerbella, Luca Bonini, Elena Borra, Gino Coudé, Pier Francesco Ferrari, Leonardo Fogassi, Monica Maranesi, Francesca Rodà, Luciano Simone, Francesca Ugolotti Serventi, Stefano Rozzi

Erschienen in: Brain Structure and Function | Ausgabe 4/2018

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Abstract

Mirror neurons (MNs) are a class of cells originally discovered in the monkey ventral premotor cortex (PMv) and inferior parietal lobule (IPL). They discharge during both action execution and action observation and appear to play a crucial role in understanding others’ actions. It has been proposed that the mirror mechanism is based on a match between the visual description of actions, encoded in temporal cortical regions, and their motor representation, provided by PMv and IPL. However, neurons responding to action observation have been recently found in other cortical regions, suggesting that the mirror mechanism relies on a wider network. Here we provide the first description of this network by injecting neural tracers into physiologically identified IPL and PMv sectors containing hand MNs. Our results show that these sectors are reciprocally connected, in line with the current view, but IPL MN sectors showed virtually no direct connection with temporal visual areas. In addition, we found that PMv and IPL MN sectors share connections with several cortical regions, including the dorsal and mesial premotor cortex, the primary motor cortex, the secondary somatosensory cortex, the mid-dorsal insula and the ventrolateral prefrontal cortex, as well as subcortical structures, such as motor and polysensory thalamic nuclei and the mid-dorsal claustrum. We propose that each of these regions constitutes a node of an “extended network”, through which information relative to ongoing movements, social context, environmental contingencies, abstract rules, and internal states can influence MN activity and contribute to several socio-cognitive functions.

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Titel: Cortical and subcortical connections of parietal and premotor nodes of the monkey hand mirror neuron network
verfasst von: Stefania Bruni
Marzio Gerbella
Luca Bonini
Elena Borra
Gino Coudé
Pier Francesco Ferrari
Leonardo Fogassi
Monica Maranesi
Francesca Rodà
Luciano Simone
Francesca Ugolotti Serventi
Stefano Rozzi
Publikationsdatum: 01.12.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Brain Structure and Function / Ausgabe 4/2018
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-017-1582-0

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Auch ein sehr ausgedehnter ischämischer Schlaganfall scheint an sich kein Grund zu sein, von einer mechanischen Thrombektomie abzusehen. Dafür spricht die LASTE-Studie, an der Patienten und Patientinnen mit einem ASPECTS von maximal 5 beteiligt waren.

Update Neurologie

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Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

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