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Medical Microbiology and Immunology
Erschienen in: Medical Microbiology and Immunology 4/2009

01.11.2009 | Review

The clinical value of neutrophil extracellular traps

verfasst von: Tim Lögters, Stefan Margraf, Jens Altrichter, Jindrich Cinatl, Steffen Mitzner, Joachim Windolf, Martin Scholz

Erschienen in: Medical Microbiology and Immunology | Ausgabe 4/2009

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Abstract

Neutrophil extracellular traps (NETs) have recently been discovered as a central part of antimicrobial innate immunity. In the meanwhile, evidence accumulated that NETs are also generated upon non-infectious stimuli in various clinical settings. In acute or chronic inflammatory disorders aberrantly enhanced NET formation and/or decreased NET degradation seems to correlate with disease outcome. This review summarizes current knowledge about the relation of NETs in a broad spectrum of clinical settings. Specifically, we focus on the importance of NETs as a predictive marker in severely ill patients and further, we speculate about the potential pathophysiology of NETs.
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Metadaten
Titel
The clinical value of neutrophil extracellular traps
verfasst von
Tim Lögters
Stefan Margraf
Jens Altrichter
Jindrich Cinatl
Steffen Mitzner
Joachim Windolf
Martin Scholz
Publikationsdatum
01.11.2009
Verlag
Springer-Verlag
Erschienen in
Medical Microbiology and Immunology / Ausgabe 4/2009
Print ISSN: 0300-8584
Elektronische ISSN: 1432-1831
DOI
https://doi.org/10.1007/s00430-009-0121-x

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