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Journal of Cancer Research and Clinical Oncology

Erschienen in:

01.08.2009 | Original Paper

Palliative radiation therapy for hemorrhage of unresectable gastric cancer: a single institute experience

verfasst von: Kenji Hashimoto, Hiroshi Mayahara, Atsuo Takashima, Takako Eguchi Nakajima, Ken Kato, Tetsuya Hamaguchi, Yoshinori Ito, Yasuhide Yamada, Yoshikazu Kagami, Jun Itami, Yasuhiro Shimada

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 8/2009

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Abstract

Purpose

To clarify the toxicity of palliative radiotherapy (RT) and its efficacy against bleeding of unresectable gastric cancer.

Methods

Clinical data of 19 patients received palliative RT for bleeding from unresectable gastric cancer were reviewed. The median total dose and dose per fraction were 40 Gy (range 2–50 Gy) and 2.5 Gy (range 1.8–3 Gy).

Results

The treatment success rate was 68.4%. By using a tumor alpha/beta ratio of 10, biological effective dose of 50 Gy₁₀ or more was significantly correlated with treatment success (P = 0.040). The median event-free survival was 1.5 months after RT and the median overall survival from starting RT was 3.4 months. Grade 3 nausea and anorexia were recorded in 1 and 3 patients, respectively.

Conclusion

Palliative RT was effective for hemostasis in patients with gastric cancer bleeding with minor adverse events.

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Titel: Palliative radiation therapy for hemorrhage of unresectable gastric cancer: a single institute experience
verfasst von: Kenji Hashimoto
Hiroshi Mayahara
Atsuo Takashima
Takako Eguchi Nakajima
Ken Kato
Tetsuya Hamaguchi
Yoshinori Ito
Yasuhide Yamada
Yoshikazu Kagami
Jun Itami
Yasuhiro Shimada
Publikationsdatum: 01.08.2009
Verlag: Springer-Verlag
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 8/2009
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-009-0553-0

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Palliative radiation therapy for hemorrhage of unresectable gastric cancer: a single institute experience