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Journal of Cancer Research and Clinical Oncology

Erschienen in:

29.01.2021 | Review – Cancer Research

Emerging role of exosomes and exosomal microRNA in cancer: pathophysiology and clinical potential

verfasst von: Mohamed Ibrahim Elewaily, Alyaa R. Elsergany

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 3/2021

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Abstract

Background

Exosomes are extracellular nanometric vesicles used by cells to communicate with each other. They are responsible for many pathological conditions, including tumors by transferring regulatory biomolecules that impact target cell activity. Because of their high concentration in exosomes compared with parental cells and the rest of exosomal content, specificity to the cell of origin, and their well-organized sorting mechanism, microRNAs (miRNAs) are thought to be the most potent exosomes cargo and used by scientists to track exosomes and to detect cell activity changes and prognosis in cancer early.

Purpose

In this review, the results of studies examining the role of exosomes in cancer pathophysiology and their clinical potential are discussed in detail.

Summary of the Findings

Tumor-derived exosomes (TDEs) mediate the dynamic changes of cancer growth and invasion, including local microenvironment remodeling, distance metastasis, angiogenesis, and tumor-associated immunosuppression. They also contribute to hypoxia-induced tumor progression and cancer cell drug resistance. As a result of exosomes being present in all body fluids, it is possible to have early accessible and less-invasive diagnostic and prognostic measures by forming a table for each cancer type and its matched specific miRNAs. Under testing, available therapeutic uses of exosomes include interference of exosomes biogenesis, secretion, or uptake, and recruitment of exosomes as target-specific drug delivery vehicles, and immunostimulatory agents for both cancer patients and healthy population to avoid cancer development from the start.

Conclusion

These data suggest that exosomes and exosomal microRNA are directly related to cancer progression mechanisms, and could be used in cancer early diagnosis, prognosis, and therapy.

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Titel: Emerging role of exosomes and exosomal microRNA in cancer: pathophysiology and clinical potential
verfasst von: Mohamed Ibrahim Elewaily
Alyaa R. Elsergany
Publikationsdatum: 29.01.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 3/2021
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-021-03534-5

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Emerging role of exosomes and exosomal microRNA in cancer: pathophysiology and clinical potential

Abstract

Background

Purpose

Summary of the Findings

Conclusion

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Live-Webinar "Urologie und Sexualmedizin in der Praxis"

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Abstract

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Conclusion

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