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Comparative Clinical Pathology

Erschienen in:

01.12.2011 | Original Article

Immuno-histochemical staining expression of Ki67 protein in canine mammary gland carcinoma

verfasst von: Annahita Rezaie, Abbas Tavasoli, Mitra Mehrazma, Alireza Bahonar

Erschienen in: Comparative Clinical Pathology | Ausgabe 6/2011

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Abstract

Canine mammary gland carcinoma is ranked second after skin tumours in dogs in terms of frequency. Due to certain microscopic and biological features, canine tumours are very similar to human carcinomas, which may make the dog a good animal model. The objective of this study was to describe Ki67 protein expression properties using immuno-histochemical (IHC) staining using human antibody. In this study, 30 mammary gland tumour samples were studied. The histological diagnosis was made on the basis of the current World Health Organization classification for canine mammary tumours. Tumours were then graded histologically in accordance with the Elston and Ellis method for human breast tumours. IHC staining using MIB-1 antibody for detecting expression of Ki67 proteins (pKi67), was performed on canine mammary gland carcinoma tissue. Results from the semi-quantitative IHC assessment of pKi67 showed that 20% were negative, 20% were one plus, 36.5% were two plus, 23.3% were three plus. There was a significant difference between histological grade and pKi67 expression. This method would help the pathologist and clinician in determining a more accurate prognosis and treatment in canine mammary carcinoma and facilitate comparative studies of canine and human research.

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Titel: Immuno-histochemical staining expression of Ki67 protein in canine mammary gland carcinoma
verfasst von: Annahita Rezaie
Abbas Tavasoli
Mitra Mehrazma
Alireza Bahonar
Publikationsdatum: 01.12.2011
Verlag: Springer-Verlag
Erschienen in: Comparative Clinical Pathology / Ausgabe 6/2011
Print ISSN: 1618-5641
Elektronische ISSN: 1618-565X
DOI: https://doi.org/10.1007/s00580-010-1032-3

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Immuno-histochemical staining expression of Ki67 protein in canine mammary gland carcinoma

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

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