Introduction
Methods
Patient population
Data collection
Signal acquisition
Signal processing
Data processing
Cerebrovascular reactivity indices
Statistics
Results
Patient population
Median (IQR) | ||
---|---|---|
Number of patients | 204 | |
Age (years) | 47.5 (29 to 62.3)) | |
Sex | Male | 163 |
Female | 41 | |
Admission GCS (total) | 7 (4 to 13) | |
Admission GCS motor | 4 (2 to 6) | |
Duration of high-frequency cranial physiologic recording (hours) | 136.0 (90.2 to 182.3) | |
ICP (mmHg) | 12.2 (9.3 to 15.4) | |
CPP (mmHg) | 70.9 (64.4 to 76.8) | |
% Time with ICP > 20 mmHg | 4.7 (0.9 to 15.7) | |
% Time with ICP > 22 mmHg | 2.8 (0.5 to 9.7) | |
Mean PRx | 0.038 (− 0.071 to 0.164) | |
Mean PAx | − 0.030 (− 0.169 to 0.093) | |
Mean RAC | − 0.296 (− 0.484 to − 0.129) | |
% Time with PRx > 0 | 52.5 (40.2 to 67.8) | |
% Time with PRx > + 0.25 | 28.1 (19.1 to 41.4) | |
% Time with PRx > + 0.35 | 21.1 (14.0 to 31.2) | |
% Time with PAx > 0 | 45.8 (30.8 to 62.0) | |
% Time with PAx > + 0.25 | 21.0 (12.4 to 35.4) | |
% Time with RAC > − 0.10 | 27.0 (14.0 to 44.9) | |
% Time with RAC > − 0.05 | 22.5 (11.8 to 39.9) | |
Mean hourly dose of PRx > 0 | 8.9 (6.3 tot 13.0) | |
Mean hourly dose of PRx > + 0.25 | 3.7 (2.5 to 5.8) | |
Mean hourly dose of PRx > + 0.35 | 2.5 (1.5 to 3.9) | |
Mean hourly dose of PAx > 0 | 6.4 (4.0 to 10.2) | |
Mean hourly dose of PAx > + 0.25 | 2.3 (1.2 to 3.9) | |
Mean hourly dose of RAC > − 0.10 | 3.6 (1.9 to 7.1) | |
Mean hourly dose of RAC > − 0.05 | 3.0 (1.5 to 6.0) | |
6- to 12-month GOSE | 4 (2 to 6) | |
Number alive—6 to 12 months | 155 | |
Number dead—6 to 12 months | 49 | |
Number favorable outcome—6 to 12 months (GOSE 5 to 8) | 109 | |
Number unfavorable outcome—6 to 12 months (GOSE 1 to 4) | 96 |
Mean/Median (± sd or IQR) | p value | |||
---|---|---|---|---|
Alive | Dead | |||
Number of patients | 155 | 49 | ||
Age (years) | 43.5 (18.4) | 56.6 (18.7) |
< 0.0001
| |
Sex | Male | 128 | 35 | 0.089 |
Female | 27 | 13 | ||
Admission GCS (total) | 7 (5 to 13) | 8 (3 to 13) | 0.707 | |
Admission GCS motor | 4 (2 to 5) | 4 (1 to 6) | 0.863 | |
Duration of high-frequency physiologic recording (hours) | 164.1 (118.5) | 145.1 (96.6) | 0.472 | |
ICP (mmHg) | 12.2 (5.9) | 19.9 (15.6) |
0.028
| |
CPP (mmHg) | 71.1 (8.8) | 66.6 (17.5) | 0.583 | |
% Time with ICP > 20 mmHg | 10.7 (18.5) | 32.4 (35.5) |
0.025
| |
% Time with ICP > 22 mmHg | 7.1 (15.2) | 27.6 (34.0) |
0.012
| |
Mean PRx | 0.017 (0.150) | 0.226 (0.269) |
< 0.0001
| |
Mean PAx | − 0.064 (0.175) | 0.126 (0.223) |
< 0.0001
| |
Mean RAC | − 0.347 (0.241) | − 0.114 (0.276) |
< 0.0001
| |
% Time with PRx > 0 | 50.2 (16.7) | 66.6 (20.5) |
< 0.0001
| |
% Time with PRx > + 0.25 | 28.5 (14.1) | 48.0 (25.0) |
< 0.0001
| |
% Time with PRx > + 0.35 | 21.4 (12.2) | 41.0 (25.7) |
< 0.0001
| |
% Time with PAx > 0 | 42.7 (18.7) | 59.8 (20.9) |
< 0.0001
| |
% Time with PAx > + 0.25 | 21.6 (14.6) | 39.6 (22.9) |
< 0.0001
| |
% Time with RAC > − 0.10 | 27.7 (20.1) | 46.8 (23.7) |
< 0.0001
| |
% Time with RAC > − 0.05 | 24.6 (18.8) | 43.3 (23.5) |
< 0.0001
| |
Mean hourly dose of PRx > 0 | 9.1 (4.6) | 15.7 (11.9) |
0.001
| |
Mean hourly dose of PRx > + 0.25 | 3.9 (2.6) | 8.7 (8.8) |
0.001
| |
Mean hourly dose of PRx > + 0.35 | 2.6 (1.9) | 6.6 (7.5) |
0.001
| |
Mean hourly dose of PAx > 0 | 6.7 (4.3) | 12.1 (8.9) |
0.001
| |
Mean hourly dose of PAx > + 0.25 | 2.5 (2.2) | 6.0 (5.9) |
< 0.0001
| |
Mean hourly dose of RAC > − 0.10 | 4.4 (4.2) | 9.6 (8.3) |
< 0.0001
| |
Mean hourly dose of RAC > − 0.05 | 3.8 (3.7) | 8.5 (7.7) |
< 0.0001
|
Mean/median (± sd or IQR) | p value | |||
---|---|---|---|---|
Favorable | Unfavorable | |||
Number of patients
| 95 | 109 | ||
Age (years)
| 40.9 (17.3) | 51.6 (19.6) |
< 0.0001
| |
Sex
|
Male
| 85 | 78 | 0.463 |
Female
| 10 | 31 | ||
Admission GCS (total)
| 8 (6 to 13) | 7 (4 to 11) | 0.136 | |
Admission GCS motor
| 5 (3 to 6) | 4 (1 to 6) | 0.110 | |
Duration of high-frequency physiologic recording (hours)
| 151.6 (119.1) | 166.5 (108.8) | 0.125 | |
ICP (mmHg)
| 12.7 (6.6) | 15.3 (11.7) | 0.876 | |
CPP (mmHg)
| 71.0 (8.9) | 68.8 (13.6) | 1.000 | |
% Time with ICP > 20 mmHg
| 11.0 (19.1) | 20.3 (29.2) | 0.482 | |
% Time with ICP > 22 mmHg
| 7.4 (16.3) | 16.0 (26.7) | 0.310 | |
Mean PRx
| 0.006 (0.153) | 0.121 (0.230) |
0.001
| |
Mean PAx
| − 0.082 (0.173) | 0.036 (0.219) |
0.001
| |
Mean RAC
| − 0.387 (0.233) | − 0.207 (0.269) |
< 0.0001
| |
% Time with PRx > 0
| 49.1 (16.9) | 58.6 (19.7) |
0.002
| |
% Time with PRx > + 0.25
| 27.5 (14.4) | 38.1 (21.4) |
0.001
| |
% Time with PRx > + 0.35
| 20.6 (12.5) | 30.9 (21.2) |
0.001
| |
% Time with PAx > 0
| 40.8 (18.4) | 52.1 (21.0) |
0.001
| |
% Time with PAx > + 0.25
| 20.1 (14.2) | 31.0 (20.3) |
< 0.0001
| |
% Time with RAC > − 0.10 | 24.4 (18.6) | 39.1 (23.4) |
< 0.0001
| |
% Time with RAC > − 0.05 | 21.7 (17.4) | 35.6 (22.8) |
< 0.0001
| |
Mean hourly dose of PRx > 0
| 8.7 (4.6) | 12.5 (9.1) |
0.003
| |
Mean hourly dose of PRx > + 0.25
| 3.7 (2.6) | 6.3 (6.6) |
0.001
| |
Mean hourly dose of PRx > + 0.35
| 2.4 (1.9) | 4.6 (5.5) |
0.001
| |
Mean hourly dose of PAx > 0
| 6.1 (4.1) | 9.6 (7.2) |
0.001
| |
Mean hourly dose of PAx > + 0.25
| 2.3 (2.1) | 4.3 (4.5) |
< 0.0001
| |
Mean hourly dose of RAC > − 0.10 | 3.7 (3.4) | 7.4 (7.0) |
< 0.0001
| |
Mean hourly dose of RAC > − 0.05 | 3.1 (2.9) | 6.4 (6.4) |
< 0.0001
|
Comparison between dichotomized outcome groups
Model | AUC A/D (95% CI) | p value | AUC F/U (95% CI) | p value |
---|---|---|---|---|
Mean PRx
| 0.748 (0.662–x`0.834) |
< 0.0001
| 0.649 (0.574–0.724) |
0.0002
|
Mean PAx
| 0.739 (0.654–0.825) |
< 0.0001
| 0.658 (0.583–0.732) |
< 0.0001
|
Mean RAC
| 0.742 (0.661–0.823) |
< 0.0001
| 0.691 (0.619–0.763) |
< 0.0001
|
% Time above PRx thresholds | ||||
% Time above 0
| 0.731 (0.643–0.818) |
< 0.0001
| 0.637 (0.561–0.712) |
0.0005
|
% Time above + 0.25
| 0.736 (0.648–0.824) |
< 0.0001
| 0.647 (0.572–0.722) |
0.0002
|
% time above + 0.35
| 0.737 (0.648–0.825) |
< 0.0001
| 0.651 (0.576–0.726) |
0.0002
|
% Time above PAx threshold | ||||
% Time above 0
| 0.729 (0.644–0.813) |
< 0.0001
| 0.656 (0.581–0.730) |
0.0001
|
% Time above + 0.25
| 0.741 (0.657–0.825) |
< 0.0001
| 0.670 (0.596–0.743) |
< 0.0001
|
% time above RAC thresholds | ||||
% Time above − 0.10
| 0.736 (0.657–0.816) |
< 0.0001
| 0.692 (0.620–0.764) |
< 0.0001
|
% Time above − 0.05
| 0.738 (0.659–0.818) |
< 0.0001
| 0.691 (0.619–0.763) |
< 0.0001
|
Hourly dose above PRx thresholds | ||||
Mean dose above 0
| 0.680 (0.586–0.774) |
< 0.0001
| 0.631 (0.555–0.707) |
0.0009
|
Mean dose above + 0.25
| 0.696 (0.604–0.787) |
< 0.0001
| 0.641 (0.565–0.716) |
0.0013
|
mean dose above + 0.35
| 0.701 (0.610–0.793) |
< 0.0001
| 0.647 (0.572–0.722) |
0.0017
|
Hourly dose above PAx thresholds | ||||
Mean dose above 0
| 0.694 (0.602–0.785) |
< 0.0001
| 0.659 (0.585–0.733) |
0.0002
|
Mean dose above + 0.25
| 0.719 (0.631–0.806) |
< 0.0001
| 0.675 (0.602–0.748) |
0.0004
|
Hourly dose above RAC thresholds | ||||
Mean dose above − 0.10
| 0.717 (0.635–0.800) |
< 0.0001
| 0.690 (0.618–0.762) |
< 0.0001
|
Mean dose above − 0.05
| 0.720 (0.637–0.803) |
< 0.0001
| 0.692 (0.620–0.763) |
< 0.0001
|