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Acta Neurochirurgica

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06.07.2021 | Review Article - Brain Tumors

Prevalence of incidental meningiomas and gliomas on MRI: a meta-analysis and meta-regression analysis

verfasst von: Satoshi Nakasu, Akifumi Notsu, Yoko Nakasu

Erschienen in: Acta Neurochirurgica | Ausgabe 12/2021

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Abstract

Background

The chance of incidentally detecting brain tumors is increasing as the utilization of magnetic resonance imaging (MRI) becomes more prevalent. In this background, knowledge is accumulating in relation to the prediction of their clinical sequence. However, their prevalence—especially the prevalence of glioma—has not been adequately investigated according to age, sex, and region.

Method

We systematically reviewed the articles according to the PRISMA statement and calculated the prevalence of meningiomas and diffuse gliomas in adults using a generalized linear mixed model. Specifically, the differences related to age, sex, and region were investigated.

Results

The pooled prevalence of incidental meningiomas in MRI studies was 0.52% (95% confidence interval (CI) [0.34–0.78]) in 37,697 individuals from 36 studies. A meta-regression analysis showed that the prevalence was significantly higher in elderly individuals, women, and individuals outside Asia; this remained statistically significant in the multivariate meta-regression analysis. The prevalence reached to 3% at 90 years of age. In contrast, the prevalence of gliomas in 30,918 individuals from 18 studies was 0.064% (95%CI [0.040 – 0.104]). The meta-regression analysis did not show a significant relationship between the prevalence and age, male sex, or region. The prevalence of histologically confirmed glioma was 0.026% (95%CI [0.013–0.052]).

Conclusions

Most of meningiomas, especially those in elderlies, remained asymptomatic, and their prevalence increased with age. However, the prevalence of incidental gliomas was much lower and did not increase with age. The number of gliomas that developed and the number that reached a symptomatic stage appeared to be balanced.

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Alturkustani A, Bock Y, Bajunaid K, Lingawi S, Baeesa S (2020) Significant incidental brain magnetic resonance imaging findings in migraine headache patients: retrospective cross-sectional study. Clin Neurol Neurosurg 196:106019. https://doi.org/10.1016/j.clineuro.2020.106019CrossRefPubMed

Arora RS, Alston RD, Eden TOB, Estlin EJ, Moran A, Birch JM (2009) Age–incidence patterns of primary CNS tumors in children, adolescents, and adults in England. Neuro Oncol 11:403–413. https://doi.org/10.1215/15228517-CrossRefPubMedPubMedCentral

Bos D, Poels MMF, Adams HHH, Akoudad S, Cremers LGM, Zonneveld HI, Hoogendam YY, Verhaaren BFJ, Verlinden VJA, Verbruggen JGJ, Peymani A, Hofman A, Krestin GP, Vincent AJ, Feelders RA, Koudstaal PJ, Van Der Lugt A, Ikram MA, Vernooij MW (2016) Prevalence, clinical management, and natural course of incidental findings on brain MR images: the population-based Rotterdam scan study. Radiology 281:507–515. https://doi.org/10.1148/radiol.2016160218CrossRefPubMed

Boutet C, Vassal F, Celle S, Schneider FC, Barthelemy JC, Laurent B, Barral FG, Roche F (2017) Incidental findings on brain magnetic resonance imaging in the elderly:the PROOF study. Brain Imaging Behav 11:293–299. https://doi.org/10.1007/s11682-016-9519-4CrossRefPubMed

Brugulat-Serrat A, Rojas S, Bargallo N, Conesa G, Minguillon C, Fauria K, Gramunt N, Molinuevo JL, Gispert JD (2017) Incidental findings on brain MRI of cognitively normal first-degree descendants of patients with Alzheimer’s disease: a cross-sectional analysis from the ALFA (Alzheimer and Families) project. BMJ Open 7:e013215. https://doi.org/10.1136/bmjopen-2016-013215CrossRefPubMedPubMedCentral

Cea-Soriano L, Wallander MA, Garcia Rodriguez LA (2012) Epidemiology of meningioma in the United Kingdom. Neuroepidemiology 39:27–34. https://doi.org/10.1159/000338081CrossRefPubMed

Cerhan JH, Butts AM, Syrjanen JA, Aakre JA, Brown PD, Petersen RC, Jack CR Jr, Roberts RO (2019) Factors Associated With Meningioma Detected in a Population-Based Sample. Mayo Clin Proc 94:254–261. https://doi.org/10.1016/j.mayocp.2018.07.026CrossRefPubMed

Champeaux C, Weller J, Katsahian S (2019) Epidemiology of meningiomas. A nationwide study of surgically treated tumours on French medico-administrative data. Cancer Epidemiol 58:63–70. https://doi.org/10.1016/j.canep.2018.11.004CrossRefPubMed

Cieszanowski A, Maj E, Kulisiewicz P, Grudzinski IP, Jakoniuk-Glodala K, Chlipala-Nitek I, Kaczynski B, Rowinski O (2014) Non-contrast-enhanced whole-body magnetic resonance imaging in the general population: the incidence of abnormal findings in patients 50 years old and younger compared to older subjects. PLoS ONE 9:e107840. https://doi.org/10.1371/journal.pone.0107840CrossRefPubMedPubMedCentral

10.

Darlix A, Zouaoui S, Rigau V, Bessaoud F, Figarella-Branger D, Mathieu-Daude H, Tretarre B, Bauchet F, Duffau H, Taillandier L, Bauchet L (2017) Epidemiology for primary brain tumors: a nationwide population-based study. J Neurooncol 131:525–546. https://doi.org/10.1007/s11060-016-2318-3CrossRefPubMed

11.

Dho YS, Jung KW, Ha J, Seo Y, Park CK, Won YJ, Yoo H (2017) An updated nationwide epidemiology of primary brain tumors in Republic of Korea, 2013. Brain Tumor Res Treat 5:16–23. https://doi.org/10.14791/btrt.2017.5.1.16CrossRefPubMedPubMedCentral

12.

Dolecek TA, Dressler EV, Thakkar JP, Liu M, Al-Qaisi A, Villano JL (2015) Epidemiology of meningiomas post-Public Law 107–206: the Benign Brain Tumor Cancer Registries Amendment Act. Cancer 121:2400–2410. https://doi.org/10.1002/cncr.29379CrossRefPubMed

13.

Ezzat S, Asa SL, Couldwell WT, Barr CE, Dodge WE, Vance ML, McCutcheon IE (2004) The prevalence of pituitary adenomas: a systematic review. Cancer 101:613–619. https://doi.org/10.1002/cncr.20412CrossRefPubMed

14.

Fuentes-Raspall R, Solans M, Roca-Barcelo A, Vilardell L, Puigdemont M, Del Barco S, Comas R, Garcia-Velasco A, Astudillo A, Carmona-Garcia MC, Marcos-Gragera R (2017) Descriptive epidemiology of primary malignant and non-malignant central nervous tumors in Spain: results from the Girona Cancer Registry (1994–2013). Cancer Epidemiol 50:1–8. https://doi.org/10.1016/j.canep.2017.07.005CrossRefPubMed

15.

Gibson LM, Paul L, Chappell FM, Macleod M, Whiteley WN, Al-Shahi Salman R, Wardlaw JM, Sudlow CLM (2018) Potentially serious incidental findings on brain and body magnetic resonance imaging of apparently asymptomatic adults: systematic review and meta-analysis. BMJ 363:k4577. https://doi.org/10.1136/bmj.k4577CrossRefPubMedPubMedCentral

16.

Glasmacher SA, Thomas HS, Stirland L, Wilkinson T, Lumsden J, Langlands G, Waddell B, Holloway G, Thompson G, Pal S (2020) Incidental findings identified on head MRI for investigation of cognitive impairment: a retrospective review. Dement Geriatr Cogn Disord 48:123–130. https://doi.org/10.1159/000503956CrossRef

17.

Gogos AJ, Young JS, Pereira MP, Morshed RA, Potts MB, Hervey-Jumper SL, Berger MS (2020) Surgical management of incidentally discovered low-grade gliomas. Journal of Neurosurgery:1–8. https://doi.org/10.3171/2020.6.Jns201296

18.

Haberg AK, Hammer TA, Kvistad KA, Rydland J, Muller TB, Eikenes L, Garseth M, Stovner LJ (2016) Incidental intracranial findings and their clinical impact; the HUNT MRI study in a general population of 1006 participants between 50–66 years. PLoS ONE 11:e0151080. https://doi.org/10.1371/journal.pone.0151080CrossRefPubMedPubMedCentral

19.

Hartwigsen GSH, Deuschl G, Jansen O, Ulmer S (2010) Incidental findings are frequent in young healthy individuals undergoing magnetic resonance imaging in brain research imaging studies: a prospective single-center study. J Comput Assist Tomogr 34:596–600CrossRef

20.

Hedderich DM, Boeckh-Behrens T, Bauml JG, Menegaux A, Daamen M, Zimmer C, Bartmann P, Scheef L, Boecker H, Wolke D, Sorg C, Spiro JE (2020) Sequelae of premature birth in young adults : incidental findings on routine brain MRI. Clin Neuroradiol. https://doi.org/10.1007/s00062-020-00901-6CrossRefPubMedPubMedCentral

21.

Hegenscheid K, Seipel R, Schmidt CO, Volzke H, Kuhn JP, Biffar R, Kroemer HK, Hosten N, Puls R (2013) Potentially relevant incidental findings on research whole-body MRI in the general adult population: frequencies and management. Eur Radiol 23:816–826. https://doi.org/10.1007/s00330-012-2636-6CrossRefPubMed

22.

Hoffman S, Propp JM, McCarthy BJ (2006) Temporal trends in incidence of primary brain tumors in the United States, 1985–19991. Neuro Oncol 8:27–37CrossRef

23.

Hunter JP, Saratzis A, Sutton AJ, Boucher RH, Sayers RD, Bown MJ (2014) In meta-analyses of proportion studies, funnel plots were found to be an inaccurate method of assessing publication bias. J ClinEpidemiol 67:897–903

24.

Ikeda K, Kuwajima A, Hosozawa K, Anan K, Iwasaki Y, Kinoshita M, Takahashi I, Kumagai K, Kashihara H, Moroka M, Miura O, Tamura M (2002) Incidence of primary brain tumors in Japanese adults: brain checkup-based evidence. A crucial role omultiphasic health testings. HEP 29:772–774CrossRef

25.

Illes J, Rosen A, Huang L, Goldstein RA, Raffin TA, Swan G, Atlas SW (2004) Ethical consideration of incidental findings on adult brain MRI in research. Neurology 63:888–890CrossRef

26.

Kalasauskas D, Keric N, Abu Ajaj S, von Cube L, Ringel F, Renovanz M (2020) Psychological burden in meningioma patients under a wait-and-watch strategy and after complete resection is high-results of a prospective single center study. Cancers (Basel) 12. https://doi.org/10.3390/cancers12123503

27.

Katzman GL, Dagher AP, Patronas NJ (1999) Incidental findings on brain magnetic resonance imaging from 1000 asymptomatic volunteers. JAMA 282:36–39CrossRef

28.

Keuss SE, Parker TD, Lane CA, Hoskote C, Shah S, Cash DM, Keshavan A, Buchanan SM, Murray-Smith H, Wong A, James SN, Lu K, Collins J, Beasley DG, Malone IB, Thomas DL, Barnes A, Richards M, Fox N, Schott JM (2019) Incidental findings on brain imaging and blood tests: results from the first phase of Insight 46, a prospective observational substudy of the 1946 British birth cohort. BMJ Open 9:e029502. https://doi.org/10.1136/bmjopen-2019-029502CrossRefPubMedPubMedCentral

29.

Koncz R, Mohan A, Dawes L, Thalamuthu A, Wright M, Ames D, Lee T, Trollor J, Wen W, Sachdev P (2018) Incidental findings on cerebral MRI in twins: the older Australian twins study. Brain Imaging Behav 12:860–869. https://doi.org/10.1007/s11682-017-9747-2CrossRefPubMed

30.

Krampla W, Newrkla S, Pfisterer W, Jungwirth S, Fischer P, Leitha T, Hruby W, Tragl KH (2004) Frequency and risk factors for meningioma in clinically healthy 75-year-old patients: results of the Transdanube ageing study (VITA). Cancer 100:1208–1212. https://doi.org/10.1002/cncr.20088CrossRefPubMed

31.

Kumar R, Sachdev PS, Price JL, Rosenman S, Christensen H (2008) Incidental brain MRI abnormalities in 60- to 64-year-old community-dwelling individuals: data from the personality and total health through life study. Acta Neuropsychiatr 20:87–90. https://doi.org/10.1111/j.1601-5215.2008.00273.xCrossRefPubMed

32.

Laible M, Schoenberg SO, Weckbach S, Lettau M, Winnik E, Bischof J, Franke R, Reiser M, Kramer H (2012) Whole-body MRI and MRA for evaluation of the prevalence of atherosclerosis in a cohort of subjectively healthy individuals. Insights Imaging 3:485–493. https://doi.org/10.1007/s13244-012-0180-1CrossRefPubMedPubMedCentral

33.

Lee W-J, Chang L-B, Lee Y-C (2008) Incidental findings on brain MRI. N Eng J Med 358:853–854CrossRef

34.

Li S, Fang F, Cui M, Jiang Y, Wang Y, Kong X, Tian W, Fan M, Yuan Z, Chen J, Yang Q, Xue F, Wang J, Lu M, Wang X, Chen X, Jin L, Ye W (2019) Incidental findings on brain MRI among Chinese at the age of 55–65 years: the Taizhou imaging study. Sci Rep 9:464. https://doi.org/10.1038/s41598-018-36893-0CrossRefPubMedPubMedCentral

35.

Li W, Zheng J, Wen W, Sachdev P Incidental brain findings on MRI in the general elderly population: the memory and aging study (MAS). In, 2010. European Congress of Radiology 2010. 10.1594/ecr2010/C-2712 (Jan 13, 2021)

36.

Li WC, Tu CH, Chao HT, Yeh TC, Chen LF, Hsieh JC (2015) High prevalence of incidental brain findings in primary dysmenorrhoea. Eur J Pain 19:1071–1074. https://doi.org/10.1002/ejp.639CrossRefPubMed

37.

Lima GL, Zanello M, Mandonnet E, Taillandier L, Pallud J, Duffau H (2016) Incidental diffuse low-grade gliomas: from early detection to preventive neuro-oncological surgery. Neurosurg Rev 39:377–384. https://doi.org/10.1007/s10143-015-0675-6CrossRefPubMed

38.

Lin DD, Lin JL, Deng XY, Li W, Li DD, Yin B, Lin J, Zhang N, Sheng HS (2019) Trends in intracranial meningioma incidence in the United States, 2004–2015. Cancer Med 8:6458–6467. https://doi.org/10.1002/cam4.2516CrossRefPubMedPubMedCentral

39.

Lo GG, Ai V, Au-Yeung KM, Li KW, Chien D (2008) Magnetic resonance whole body imaging at 3 Tesla: feasibility and findings in a cohort of asymptomatic medical doctors. Hong Kong Med J 14:90–96PubMed

40.

Louis DN (2016) WHO classification and grading of tumours of the central nervous system. WHO classification oft umours of the central nervous system. International Agency for Research on Cancer, Lyon

41.

Mandonnet E, de Witt HP, Pallud J, Bauchet L, Whittle I, Duffau H (2014) Silent diffuse low-grade glioma: toward screening and preventive treatment? Cancer 120:1758–1762. https://doi.org/10.1002/cncr.28610CrossRefPubMed

42.

Menzler K, Iwinska-Zelder J, Shiratori K, Jaeger RK, Oertel WH, Hamer HM, Rosenow F, Knake S (2010) Evaluation of MRI criteria (1.5 T) for the diagnosis of hippocampal sclerosis in healthy subjects. Epilepsy Res 89:349–354. https://doi.org/10.1016/j.eplepsyres.2010.02.010CrossRefPubMed

43.

Morris Z, Whiteley WN, Longstreth WT Jr, Weber F, Lee YC, Tsushima Y, Alphs H, Ladd SC, Warlow C, Wardlaw JM, Al-Shahi Salman R (2009) Incidental findings on brain magnetic resonance imaging: systematic review and meta-analysis. BMJ 339:b3016. https://doi.org/10.1136/bmj.b3016CrossRefPubMedPubMedCentral

44.

Mullally WJ, Hall KE (2018) Value of patient-directed brain magnetic resonance imaging scan with a diagnosis of migraine. Am J Med 131:438–441. https://doi.org/10.1016/j.amjmed.2017.10.042CrossRefPubMed

45.

Munn ZMS, Rittano D, Lisky K (2014) The development of a critical appraisal tool for use in systematic reviews addressing questions of prevalence. Int J Health Policy Manag 3:123–128CrossRef

46.

Nagai Yamaki V, de Souza Godoy LF, AlencarBandeira G, Tavares Lucato L, Correa Lordelo G, Fontoura Solla DJ, Santana Neville I, Jacobsen Teixeira M, Silva Paiva W (2021) Dural-based lesions: is it a meningioma? Neuroradiology. https://doi.org/10.1007/s00234-021-02632-yCrossRefPubMed

47.

Naing L, Winn T, Rusli BN (2006) Practical issues in calculating the sample size for prevalence studies. Arch Orofac Sci 1:9–14

48.

Nakasu S, Hirano A, Shimura T, Llena JF (1987) Incidental meningiomas in autopsy study. Surg Neurol 27:319–322CrossRef

49.

Nakasu S, Nakasu Y (2020) Natural history of meningiomas: review with meta-analyses. Neurol Med Chir (Tokyo) 60:109–120. https://doi.org/10.2176/nmc.ra.2019-0213CrossRef

50.

Neugut AI, Sackstein P, Hillyer GC, Jacobson JS, Bruce J, Lassman AB, Stieg PA (2019) Magnetic resonance imaging-based screening for asymptomatic brain tumors: a review. Oncologist 24:375–384. https://doi.org/10.1634/theoncologist.2018-0177CrossRefPubMed

51.

Ohgaki H, Kleiheus P (2005) Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendrial gliomas. J Neuropathol Exp Neurol 64:479–489CrossRef

52.

Onizuka M, Suyama K, Shibayama A, Hiura T, Horie N, Miyazaki H (2001) Asymptomtic breain tumor detected at brain check-up. Neurol Med Chir (Tokyo) 41:431–435CrossRef

53.

Ostrom QT, Gittleman H, Liao P, Vecchione-Koval T, Wolinsky Y, Kruchko C, Barnholtz-Sloan JS (2017) CBTRUS statistical report: primary brain tumors diagnosed in the United States in 2010–2014. Neuro Oncol 19:v56–v58

54.

Papanikolaou V, Khan MH, Keogh IJ (2010) Incidental findings on MRI scans of patients presenting with audiovestibular symptoms. BMC Ear Nose Throat Disord 10:6. https://doi.org/10.1186/1472-6815-10-6CrossRefPubMedPubMedCentral

55.

Rausing A, Ybo W, Stenflo J (1970) Intracranial meningioma - a population study of ten years. Acta Neurol Scandinav 46:102–110CrossRef

56.

Reneman L, de Win MM, Booij J, van den Brink W, den Heeten GJ, Freling N, Majoie CB (2012) Incidental head and neck findings on MRI in young healthy volunteers: prevalence and clinical implications. AJNR Am J Neuroradiol 33:1971–1974. https://doi.org/10.3174/ajnr.A3217CrossRefPubMedPubMedCentral

57.

Sandeman EM, Hernandez Mdel C, Morris Z, Bastin ME, Murray C, Gow AJ, Corley J, Henderson R, Deary IJ, Starr JM, Wardlaw JM (2013) Incidental findings on brain MR imaging in older community-dwelling subjects are common but serious medical consequences are rare: a cohort study. PLoS ONE 8:e71467. https://doi.org/10.1371/journal.pone.0071467CrossRefPubMedPubMedCentral

58.

Schwarzer G, Chemaitelly H, Abu-Raddad LJ, Rucker G (2019) Seriously misleading results using inverse of Freeman-Tukey double arcsine transformation in meta-analysis of single proportions. Res Synth Methods 10:476–483. https://doi.org/10.1002/jrsm.1348CrossRefPubMedPubMedCentral

59.

Serag D, Ragab E (2020) Prevalence of incidentally discovered findings on brain MRI in adult Egyptian population. Egyptian Journal of Radiology and Nuclear Medicine 51. https://doi.org/10.1186/s43055-020-00187-1

60.

Shah AH, Madhavan K, Sastry A, Komotar RJ (2013) Managing intracranial incidental findings suggestive of low-grade glioma: learning from experience. World Neurosurg 80:e75-77. https://doi.org/10.1016/j.wneu.2012.06.021CrossRefPubMed

61.

Trufyn J, Hill MD, Scott JN, Modi J, Ciura V, Frayne R, Goyal M, Lautner D, Bhayana D, Davenport WJ, Mah JK, Burton JM, Costello F (2014) The prevalence of incidental findings in multiple sclerosis patients. Can J Neurol Sci 41:49–52. https://doi.org/10.1017/s0317167100016255CrossRefPubMed

62.

Tsushima Y, Taketomi-Takahashi A, Endo K (2005) Prevalence of abnormal findings on brain magnetic resonance (MR) examinations in adult participants of brain docking. BMC Neurol 5:18. https://doi.org/10.1186/1471-2377-5-18CrossRefPubMedPubMedCentral

63.

Vazquez-Justes D, Sanahuja J, Diez J, Rubinat E, Begue R, Salas C, Vicandi C, Gil MI, Purroy F, Mauricio D (2020) Incidental findings on brain MRI in a cohort of diabetic patients. J Neuroradiol 47:343–348. https://doi.org/10.1016/j.neurad.2018.07.005CrossRefPubMed

64.

Weber F, Knopf H (2006) Incidental findings in magnetic resonance imaging of the brains of healthy young men. J Neurol Sci 240:81–84. https://doi.org/10.1016/j.jns.2005.09.008CrossRefPubMed

65.

Wijnenga MMJ, Mattni T, French PJ, Rutten GJ, Leenstra S, Kloet F, Taphoorn MJB, van den Bent MJ, Dirven CMF, van Veelen ML, Vincent A (2017) Does early resection of presumed low-grade glioma improve survival? A clinical perspective. J Neurooncol 133:137–146. https://doi.org/10.1007/s11060-017-2418-8CrossRefPubMedPubMedCentral

66.

Yue NC, Longstreth WT Jr, Elster AD, Jungreis CA, O’Leary DH, Poirier VC (1997) Clinically serious abnormalities found incidentally at MR imaging of the brain: data from the cardiovascular health study. Radiology 202:41–46CrossRef

Titel: Prevalence of incidental meningiomas and gliomas on MRI: a meta-analysis and meta-regression analysis
verfasst von: Satoshi Nakasu
Akifumi Notsu
Yoko Nakasu
Publikationsdatum: 06.07.2021
Verlag: Springer Vienna
Erschienen in: Acta Neurochirurgica / Ausgabe 12/2021
Print ISSN: 0001-6268
Elektronische ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-021-04919-8

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