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Journal of the Association for Research in Otolaryngology

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20.07.2020 | Research Article

Relationships between Intrascalar Tissue, Neuron Survival, and Cochlear Implant Function

verfasst von: Donald L. Swiderski, Deborah J. Colesa, Aaron P. Hughes, Yehoash Raphael, Bryan E. Pfingst

Erschienen in: Journal of the Association for Research in Otolaryngology | Ausgabe 4/2020

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Abstract

Fibrous tissue and/or new bone are often found surrounding a cochlear implant in the cochlear scalae. This new intrascalar tissue could potentially limit cochlear implant function by increasing impedance and altering signaling pathways between the implant and the auditory nerve. In this study, we investigated the relationship between intrascalar tissue and 5 measures of implant function in guinea pigs. Variation in both spiral ganglion neuron (SGN) survival and intrascalar tissue was produced by implanting hearing ears, ears deafened with neomycin, and neomycin-deafened ears treated with a neurotrophin. We found significant effects of SGN density on 4 functional measures but adding intrascalar tissue level to the analysis did not explain more variation in any measure than was explained by SGN density alone. These results suggest that effects of intrascalar tissue on electrical hearing are relatively unimportant in comparison to degeneration of the auditory nerve, although additional studies in human implant recipients are still needed to assess the effects of this tissue on complex hearing tasks like speech perception. The results also suggest that efforts to minimize the trauma that aggravates both tissue development and SGN loss could be beneficial.

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Titel: Relationships between Intrascalar Tissue, Neuron Survival, and Cochlear Implant Function
verfasst von: Donald L. Swiderski
Deborah J. Colesa
Aaron P. Hughes
Yehoash Raphael
Bryan E. Pfingst
Publikationsdatum: 20.07.2020
Verlag: Springer US
Erschienen in: Journal of the Association for Research in Otolaryngology / Ausgabe 4/2020
Print ISSN: 1525-3961
Elektronische ISSN: 1438-7573
DOI: https://doi.org/10.1007/s10162-020-00761-4

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Relationships between Intrascalar Tissue, Neuron Survival, and Cochlear Implant Function

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