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04.10.2020 | Review Paper

Piwi-interacting RNAs (piRNAs) as potential biomarkers and therapeutic targets for cardiovascular diseases

verfasst von: Min Li, Yanyan Yang, Zhibin Wang, Tingyu Zong, Xiuxiu Fu, Lynn Htet Htet Aung, Kun Wang, Jian-xun Wang, Tao Yu

Erschienen in: Angiogenesis | Ausgabe 1/2021

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Abstract

Cardiovascular diseases (CVDs) are the leading causes of death worldwide. Increasing reports demonstrated that non-coding RNAs (ncRNAs) have been crucially involved in the development of CVDs. Piwi-interacting RNAs (piRNAs) are a novel cluster of small non-coding RNAs with strong uracil bias at the 5′ end and 2′-O-methylation at the 3′ end that are mainly present in the mammalian reproductive system and stem cells and serve as potential modulators of developmental and pathophysiological processes. Recently, piRNAs have been reported to be widely expressed in human tissues and can potentially regulate various diseases. Specifically, concomitant with the development of next-generation sequencing techniques, piRNAs have been found to be differentially expressed in CVDs, indicating their potential involvement in the occurrence and progression of heart diseases. However, the molecular mechanisms and signaling pathways involved with piRNA function have not been fully elucidated. In this review, we present the current understanding of the piRNAs from the perspectives of biogenesis, characteristics, biological function, and regulatory mechanisms, and highlight their potential roles and underlying mechanisms in CVDs, which will provide new insights into the potential applications of piRNAs in the clinical diagnosis, prognosis, and therapeutic strategies for heart diseases.

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Titel: Piwi-interacting RNAs (piRNAs) as potential biomarkers and therapeutic targets for cardiovascular diseases
verfasst von: Min Li
Yanyan Yang
Zhibin Wang
Tingyu Zong
Xiuxiu Fu
Lynn Htet Htet Aung
Kun Wang
Jian-xun Wang
Tao Yu
Publikationsdatum: 04.10.2020
Verlag: Springer Netherlands
Erschienen in: Angiogenesis / Ausgabe 1/2021
Print ISSN: 0969-6970
Elektronische ISSN: 1573-7209
DOI: https://doi.org/10.1007/s10456-020-09750-w

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