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15.11.2018 | Substantive Review

A Systematic Review and Meta-analysis of Antiretroviral Therapy (ART) Adherence Interventions for Women Living with HIV

verfasst von: Jennifer A. Pellowski, Devon M. Price, Abigail D. Harrison, Emily L. Tuthill, Landon Myer, Don Operario, Mark N. Lurie

Erschienen in: AIDS and Behavior | Ausgabe 8/2019

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Abstract

A systematic review and meta-analysis was conducted to determine the efficacy of women-focused ART adherence interventions. Included studies (a) reported on a behavioral ART adherence intervention for cis-women living with HIV, (b) measured ART adherence as an outcome, and (c) employed a randomized controlled trial design. Thirteen studies were included in the meta-analysis. Overall, interventions significantly improved ART adherence compared to control conditions (random-effects d = 0.82, 95% CI [0.18, 1.45], p = 0.01), however, this was largely driven by two studies that had effect sizes greater than 3 standard errors above the mean effect size. Key moderators were location, recruitment method, group-based intervention, and alteration of the healthcare system. Innovative behavioral interventions that focus on young women and adolescents, target the critical periods of pregnancy and postpartum and test the integration of multiple levels of intervention to create lasting effects on ART adherence are needed.

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Harrison A, Colvin CJ, Kuo C, Swartz A, Lurie M. Sustained high HIV incidence in young women in Southern Africa: social, behavioral, and structural factors and emerging intervention approaches. Curr HIV/AIDS Rep. 2015;12(2):207–15.CrossRefPubMedPubMedCentral

UNAIDS. Fact sheet- Latest statistics on the status of the AIDS epidemic.2017 December 11, 2017.

amFAR. Statistics: Women and HIV/AIDS2017 December 11, 21017.

Poorolajal J, Hooshmand E, Mahjub H, Esmailnasab N, Jenabi E. Survival rate of AIDS disease and mortality in HIV-infected patients: a meta-analysis. Public Health. 2016;139:3–12.CrossRefPubMed

Stickler SM, Fox KA, Baggaley R, Negussie E, de Pee S, Grede N, et al. Retention in care and adherence to ART are critical elements of HIV care interventions. AIDS Behav. 2014;18(Supplement 5):S465–75.

Adetokunboh OO, Oluwasanu M. Eliminating mother-to-child transmission of the human immunodeficiency virus in sub-Saharan Africa: the journey so far and what remains to be done. J Infect Public Health. 2016;9(4):394–407.CrossRef

Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011;365(6):493–505.CrossRefPubMedPubMedCentral

Giuliano M, Andreotti M, Liotta G, Jere H, Sagno JB, Maulidi M, et al. Maternal antiretroviral therapy for the prevention of mother-to-child transmission of HIV in Malawi: maternal and infant outcomes two years after delivery. PLoS ONE. 2013;8(7):e68950.CrossRefPubMedPubMedCentral

Wilson DP, Law MG, Grulich AE, Cooper DA, Kaldor JM. Relation between HIV viral load and infectiousness: a model-based analysis. Lancet. 2008;372(9635):314–20.CrossRefPubMed

10.

Ortega C, Huedo-Medina TB, Santos P, Rodriguez E, Sevilla L, Warren M, et al. Sex differences in adherence to highly active antiretroviral therapy: a meta-analysis. AIDS Care. 2012;24(12):1519–34.CrossRef

11.

Boulle C, Kouanfack C, Laborde-Balen G, Boyer S, Aghokeng AF, Carrieri MP, et al. Gender differences in adherence and response to antiretroviral treatment in the Stratall Trial in rural district hospitals in Cameroon. J Acquir Immune Defic Syndr. 2015;69(3):355–64.CrossRefPubMed

12.

Maskew M, Brennan AT, Westreich D, McNamara L, MacPhail AP, Fox MP. Gender differences in mortality and CD4 count response among virally suppressed HIV-positive patients. J Womens Health (Larchmt). 2013;22(2):113–20.CrossRefPubMedCentral

13.

Monforte AD, Anderson J, Olczak A. What do we know about antiretroviral treatment of HIV in women? Antivir Ther. 2013;18(Supplement 2):27–34.CrossRefPubMed

14.

Puskas CM, Forrest JI, Parashar S, Salters KA, Cescon AM, Kaida A, et al. Women and the vulnerability to HAART non-adherence: a literature review of treatment adherence by gender from 2000 to 2011. Curr HIV/AIDS Rep. 2011;8:277–87.CrossRefPubMed

15.

Grigoriadis S, Robinson GE. Gender issues in depression. Ann Clin Psychiatry. 2007;19(4):247–55.CrossRefPubMed

16.

Piccinellie M, Wilkinson G. Gender differences in depression Critical Review. Br J Psychiatry. 2000;177:486–92.CrossRef

17.

Wagner GJ, Goggin K, Remien RH, Rosen MI, Simoni JM, Bangsberg DR, et al. A closer look at depression and its relationship to HIV antiretroviral adherence. Ann Behav Med. 2011;42(3):351–60.CrossRef

18.

Psaros C, Geller PA, Aaron E. The importance of identifying and treating depression in HIV infected, pregnant women: a review. J Psychosom Obstet Gynaecol. 2009;30(4):275–81.CrossRefPubMed

19.

Nachega JB, Uthman OA, Anderson J, Peltzer K, Wampold S, Cotton MF, et al. Adherence to antiretroviral therapy during and after pregnancy in low-income, middle-income, and high-income countries: a systematic review and meta-analysis. AIDS. 2012;26(16):2039–52.CrossRefPubMed

20.

Hodgson I, Plummer ML, Konopka SN, Colvin CJ, Jonas E, Albertini J, et al. A systematic review of individual and contextual factors affecting ART initiations, adherence, and retention for HIV-infected pregnant and postpartum women. PLoS ONE. 2014;9(11):e111421.CrossRefPubMedPubMedCentral

21.

Psaros C, Remmert JE, Bangsberg DR, Safren SA, Smit JA. Adherence to HIV care after pregnancy among women in sub-Saharan Africa: falling off the cliff of the treatment cascade. Curr HIV/AIDS Rep. 2015;12:1–5.CrossRefPubMedPubMedCentral

22.

Ghanotakis E, Peacock D, Wilcher R. The importance of addressing gender inequality in efforts to end vertical transmission of HIV. J Int AIDS Soc. 2012;15(Suppl 2):17385.PubMedPubMedCentral

23.

Kraft JM, Wilkins KG, Morales GJ, Widyono M, Middlestadt SE. An evidence review of gender-integrated interventions in reproductive and maternal-child health. J Health Commun. 2014;19:122–41.CrossRefPubMedPubMedCentral

24.

Haberland NA. The case for addressing gender and power in sexuality and HIV education: a comprehensive review of evaluation studies. Int Perspect Sex Reprod Health. 2015;41(1):31–42.CrossRefPubMed

25.

Stuart AS, Dokubo EK, Sint TT. Antiretroviral therapy (ART) for treating HIV infection in ART-eligible pregnant women. Cochrane Database Syst Rev. 2010;3:CD008440.

26.

White AB, Mirjahangir JF, Horvath H, Anglemyer A, Read JS. Antiretroviral interventions for preventing breast milk transmission of HIV. Cochrane Database Syst Rev. 2014;10:CD011323.

27.

Siegfried N, van der Merwe L, Brocklehurst P, Sint TT. Antiretrovirals for reducing the risk of mother-to-child transmission of HIV infection. Cochrane Database Syst Rev. 2011;7:CD003510.

28.

Tudor Car L, van-Velthoven MH, Brusamento S, Elmoniry H, Car J, Majeed A, et al. Integrating prevention of mother-to-child HIV transmission (PMTCT) programmes with other health services for preventing HIV infection and improving HIV outcomes in developing countries. Cochrane Database Syst Rev. 2011;6:CD008741.

29.

Geldsetzer P, Yapa HM, Vaikath M, Ogbuoji O, Fox MP, Essajee SM, et al. A systematic review of interventions to improve postpartum retention of women in PMTCT and ART care. J Int AIDS Soc. 2016;19(1):20679.CrossRefPubMedPubMedCentral

30.

Moher D, Liberati A, Tetzlaff J, Altman DG, Group TP. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097.CrossRefPubMedPubMedCentral

31.

Downs SH, Black N. The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health. 1998;52:377–84.CrossRefPubMedPubMedCentral

32.

Hooper P, Jutai JW, Strong G, Russel-Minda E. Age-related macular degeneration and low-vision rehabilitation: a systematic review. Can J Ophthalmol. 2008;43(2):180–7.CrossRefPubMed

33.

Faraone SV. Interpreting estimates of treatment effects: implications for managed care. Pharm Ther. 2008;33(12):700–3.

34.

Huedo-Medina TB, Johnson BT. Estimating the standardized mean difference effect size and its variance from different data sources: A spreadsheet. Storrs, CT, USA 2011.

35.

da Costa TM, Barbosa BJ, Gomes e Costa DA, Sigulem D, de Fatima Marin H, Filho AC, et al. Results of a randomized controlled trial to assess the effects of a mobile SMS-based intervention on treatment adherence in HIV/AIDS-infected Brazilian women and impressions and satisfaction with respect to incoming messages. Int J Med Inform. 2012;81(4):257–69.CrossRefPubMedPubMedCentral

36.

Holstad MM, Essien JE, Ekong E, Higgins M, Teplinskiy I, Adewuyi MF. Motivational groups support adherence to antiretroviral therapy and use of risk reduction behaviors in HIV positive Nigerian women: a pilot study. Afr J Reprod Health. 2012;16(3):14–27.PubMedPubMedCentral

37.

Messersmith LJ, Halim, N, Simmons, E, Bachman, DeSilva M, Chemusto H, Gasuza J, Sabin L. The Uganda WiseMama Study: a randomized controlled trial assessing real-time feedback to improve ART adherence among HIV-positive pregnant and postpartum women. 12th International Conference on HIV Treatment and Prevention Adherence; Miami, FL2017.

38.

Kempf M-C, Ott C, Azuero A, Stringer K, Jagielski C, Savage R, Cropsey K, Haberer J, Psaros C, Safren SA. Telemedicine-delivered cognitive behavioral therapy for adherence and depression (CBT-AD) in HIV positive women in the deep south. 11th International Conference on HIV Treatment and Prevention Adherence; Fort Lauderdale, FL2016.

39.

Sarna A, Okal J, Matheka J, Saraswati LR, Reynolds N, Kalibala S. Effectiveness of cellphone counseling on PMTCT retention and uptake of early infant diagnosis in Kisumu, Kenya. 12th International Conference on HIV Treatment and Prevention Adherence; Miami, FL2017.

40.

Surilena Ismail RI, Irwanto Djoerban Z, Utomo B, Sabarinah S, et al. The effect of rational emotive behavior therapy (REBT) on antiretroviral therapeutic adherence and mental health in women infected with HIV/AIDS. Acta Medica Indones. 2014;46(4):283–91.

41.

Webel AR. Testing a peer-based symptom management intervention for women living with HIV/AIDS. AIDS Care. 2010;22(9):1029.CrossRefPubMedPubMedCentral

42.

Kiweewa FM, Wabwire D, Nakibuuka J, Mubiru M, Bagenda D, Musoke P, et al. Noninferiority of a task-shifting HIV care and treatment model using peer counselors and nurses among Ugandan women initiated on ART: evidence from a randomized trial. J Acquir Immune Defic Syndr. 2013;63(4):e125–32.CrossRefPubMed

43.

StataCorp. Stata Statistical Software: Release 15. College Station, TX: StataCorp, LLC; 2017.

44.

Wilson DB. Meta-analysis macros for SAS, SPSS, and Stata.1998 December 12, 2017.

45.

Steichen TJ. METATRIM: Stata module to perform nonparametric analysis of publication bias. Boston College Department of Economics; 2010.

46.

Harbord RM, Harris RJ, Sterne JAC, Steichen TJ. METABIAS: Stata module to test for small-study effects in meta-analysis. Boston College Department of Economics; 2009.

47.

Huedo-Medina TB, Sanchez-Meca J, Marin-Martinez F, Botella J. Assessing heterogeneity in meta-analysis: Q statistic or I2 index. CHIP Documents. 2006;19.

48.

Duval S, Tweddie R. Trim and fill: a simple funnel-plot based method of testing and adjusting for publication bias in meta-analysis. Biometrics. 2000;56:455–63.CrossRefPubMed

49.

Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50:1088–101.CrossRefPubMed

50.

Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629–34.CrossRefPubMedPubMedCentral

51.

Holstad M, DiIorio C, Kelley M, Resnicow K, Women Sharma S. Group motivational interviewing to promote adherence to antiretroviral medications and risk reduction behaviors in HIV infected. AIDS Behav. 2011;15(5):885–96.CrossRefPubMedPubMedCentral

52.

Nyamathi A, Hanson AY, Salem BE, Sinha S, Ganguly KK, Leake B, et al. Impact of a rural village women (Asha) intervention on adherence to antiretroviral therapy in southern India. Nurs Res. 2012;61(5):353–62.CrossRefPubMedPubMedCentral

53.

Cowan JF, Micek M, Cowan JF, Napua M, Hoek R, Gimbel S, et al. Early ART initiation among HIV-positive pregnant women in central Mozambique: a stepped wedge randomized controlled trial of an optimized Option B + approach. Implement Sci. 2015;10:61.CrossRefPubMedPubMedCentral

54.

Drake AL, Unger JA, Ronen K, Matemo D, Perrier T, DeRenzi B, et al. Evaluation of mHealth strategies to optimize adherence and efficacy of Option B + prevention of mother-to-child HIV transmission: rationale, design and methods of a 3-armed randomized controlled trial. Contemp Clin Trials. 2017;57:44–50.CrossRefPubMedPubMedCentral

55.

Rosenberg NE, van Lettow M, Tweya H, Kapito-Tembo A, Bourdon CM, Cataldo F, et al. Improving PMTCT uptake and retention services through novel approaches in peer-based family-supported care in the clinic and community: a 3-arm cluster randomized trial (PURE Malawi). J Acquir Immune Defic Syndr. 1999;2014(67 Suppl 2):S114–9.

56.

Jones DL, Ishii M, LaPerriere A, Stanley H, Antoni M, Ironson G, et al. Influencing medication adherence among women with AIDS. AIDS Care. 2003;15(4):463–74.CrossRefPubMed

57.

Jones DL, McPherson-Baker S, Lydston D, Camille J, Brondolo E, Tobin JN, et al. Efficacy of a group medication adherence intervention among HIV positive women: the SMART/EST Women’s Project. AIDS Behav. 2007;11(1):79–86.CrossRefPubMedPubMedCentral

58.

Mann T. Effects of future writing and optimism on health behaviors in HIV-infected women. Ann Behav Med. 2001;23(1):26–33.CrossRefPubMed

59.

Wyatt GE, Longshore D, Chin D, Carmona JV, Loeb TB, Myers HF, et al. The efficacy of an integrated risk reduction intervention for HIV-positive women with child sexual abuse histories. AIDS Behav. 2004;8(4):453–62.CrossRefPubMed

60.

Amico KR, Harman JJ, Johnson BT. Efficacy of antiretroviral therapy adherence interventions: a research synthesis of trials, 1996–2004. J Acquir Immune Defic Syndr. 2006;41(3):285–97.CrossRefPubMed

61.

Simoni JM, Pearson CR, Pantalone DW, Marks G, Crepaz N. Efficacy of intervention in improving highly active antiretroviral therapy adherence and HIV-1 RNA viral load. J Acquir Immune Defic Syndr. 1999;2006(43):S23–35.

62.

UNAIDS. 90-90-90: An ambitious treatment target to help end the AIDS epidemic2014; (JC2684).

63.

Gonzalez JS, Penedo FJ, Antoni MH, Duran RE, McPherson-Baker S, Ironson G, et al. Social support, positive states of mind, and HIV treatment adherence in men and women living with HIV/AIDS. Health Psychol. 2004;23(4):413–8.CrossRefPubMed

64.

Simoni JM, Frick PA, Huang B. A longitudinal evaluation of a social support model of medication adherence among HIV-positive men and women on antiretroviral therapy. Health Psychol. 2006;25(1):74–81.CrossRefPubMedPubMedCentral

65.

Blackstock OJ, Shah PA, Haughton LJ, Horvath HJ, Cunningham CO. HIV-infected women’s perspectives on the use of the internet for social support: a potential role for online group-based interventions. J Assoc Nurses AIDS Care. 2015;26(4):411–9.CrossRefPubMed

66.

Dewing S, Matthews C, Lurie M, Kagee A, Padayachee T, Lombard C. Predictors of poor adherence among people on antiretroviral treatment in Cape Town, South Africa: a case-control study. AIDS Care. 2015;27(3):342–9.CrossRefPubMedPubMedCentral

67.

Simoni JM, Amico KR, Pearson CR, Malow R. Strategies for promoting adherence to antiretroviral therapy: a review of the literature. Curr Infect Dis Rep. 2008;10(6):515–21.CrossRefPubMedPubMedCentral

68.

Simoni JM, Amico KR, Smith L, Nelson K. Antiretroviral adherence interventions: translating research findings to the real world clinic. Curr HIV/AIDS Rep. 2010;7(1):44–51.CrossRefPubMedPubMedCentral

69.

Glass T, Cavassini M. Asking about adherence - from flipping the coin to strong evidence. Swiss Med Wkly. 2014;144:w14016.PubMed

70.

Rhead R, Masimirembwa C, Cooke G, Takaruza A, Nyamukapa C, Mutsimhi C, et al. Might ART adherence estimates be improved by combining biomarker and self-report data. PLoS ONE. 2016;11(12):e0167852.CrossRefPubMedPubMedCentral

71.

Cervia JS. Easing the transition of HIV-infected adolescents to adult care. AIDS Patient Care STDS. 2013;27(12):692–6.CrossRefPubMedPubMedCentral

72.

Martin SC, Wolters PL, Toledo-Tamula MA, Zeichner SL, Hazra R, Civitello L. Cognitive functioning in school-aged children with vertically acquired HIV infection being treated with highly active antiretroviral therapy (HAART). Dev Neuropsychol. 2006;30(2):633–57.CrossRefPubMed

73.

Nichols SL, Chernoff MC, Malee KM, Sirois PA, Woods SP, Williams PL, et al. Executive functioning in children and adolescents with perinatal HIV infection and perinatal HIV exposure. J Pediatric Infect Dis Soc. 2016;5:S15–23.CrossRefPubMedPubMedCentral

74.

Duff PF, Money DM, Ogilvie GS, Ranville F, Kestler M, Braschel MC, et al. Severe menopausal symptoms associated with reduced adherence to antiretroviral therapy among perimenopausal and menopausal women living with HIV in Metro Vancouver. Menopause. 2017;25(5):531–7.CrossRef

75.

Warren-Jeanpiere L, Dillaway H, Hamilton P, Young M, Goparaju L. Taking it one day at a time: African-American women aging with HIV and co-morbidities. AIDS Patient Care STDS. 2014;28(7):372–80.CrossRefPubMedPubMedCentral

Titel: A Systematic Review and Meta-analysis of Antiretroviral Therapy (ART) Adherence Interventions for Women Living with HIV
verfasst von: Jennifer A. Pellowski
Devon M. Price
Abigail D. Harrison
Emily L. Tuthill
Landon Myer
Don Operario
Mark N. Lurie
Publikationsdatum: 15.11.2018
Verlag: Springer US
Erschienen in: AIDS and Behavior / Ausgabe 8/2019
Print ISSN: 1090-7165
Elektronische ISSN: 1573-3254
DOI: https://doi.org/10.1007/s10461-018-2341-9

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