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Cancer and Metastasis Reviews

Erschienen in:

20.01.2020 | Non-Thematic Review

piRNAs: biogenesis and their potential roles in cancer

verfasst von: Binghong Guo, Dongpei Li, Likun Du, Xiao Zhu

Erschienen in: Cancer and Metastasis Reviews | Ausgabe 2/2020

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Abstract

With the length of about 26–31 nt, PIWI-interacting RNA (piRNA) is a small non-coding RNA (ncRNA) that interacts with PIWI proteins to form the piRNA silencing complex (piRISC). PIWI is a subfamily of Argonaute, and piRNA must bind to PIWI to exert its regulatory role. Current studies indicated that piRNA and PIWI are significantly abnormally expressed in gastric, breast, kidney, colon, and lung cancers, and are involved in the initiation, progression, and metastasis of cancers, which may be the potential diagnostic tools, prognostic markers, and therapeutic targets for cancers. By reviewing piRNA recent studies, this research summarized the mechanism of piRNA generation and the functions of piRNA/PIWI in gastric, breast, kidney, colon, and lung cancers, providing a reference value for further piRNA research.

Ferreira, H. J., & Esteller, M. (2018). Non-coding RNAs, epigenetics, and cancer: tying it all together. Cancer Metastasis Reviews, 37(1), 55–73. https://doi.org/10.1007/s10555-017-9715-8.CrossRefPubMed

Xiao, Y., & Ke, A. (2016). PIWI takes a giant step. Cell, 167(2), 310–312. https://doi.org/10.1016/j.cell.2016.09.043.CrossRefPubMed

Rodriguez-Leal, D., Castillo-Cobian, A., Rodriguez-Arevalo, I., & Vielle-Calzada, J. P. (2016). A primary sequence analysis of the ARGONAUTE protein family in plants. Frontiers in Plant Science, 7, 1347. https://doi.org/10.3389/fpls.2016.01347.CrossRefPubMedPubMedCentral

Russell, S. J., & LaMarre, J. (2018). Transposons and the PIWI pathway: genome defense in gametes and embryos. Reproduction, 156(4), R111–r124. https://doi.org/10.1530/rep-18-0218.CrossRefPubMed

Theron, E., Maupetit-Mehouas, S., Pouchin, P., Baudet, L., Brasset, E., & Vaury, C. (2018). The interplay between the Argonaute proteins Piwi and Aub within Drosophila germarium is critical for oogenesis, piRNA biogenesis and TE silencing. Nucleic Acids Research, 46(19), 10052–10065. https://doi.org/10.1093/nar/gky695.CrossRefPubMedPubMedCentral

Weng, W., Li, H., & Goel, A. (2019). Piwi-interacting RNAs (piRNAs) and cancer: emerging biological concepts and potential clinical implications. Biochimica Et Biophysica Acta. Reviews on Cancer, 1871(1), 160–169. https://doi.org/10.1016/j.bbcan.2018.12.005.CrossRefPubMed

Chalbatani, G. M., Dana, H., Memari, F., Gharagozlou, E., Ashjaei, S., Kheirandish, P., Marmari, V., Mahmoudzadeh, H., Mozayani, F., Maleki, A. R., Sadeghian, E., Nia, E. Z., Miri, S. R., Nia, N. Z., Rezaeian, O., Eskandary, A., Razavi, N., Shirkhoda, M., & Rouzbahani, F. N. (2019). Biological function and molecular mechanism of piRNA in cancer. Pract Lab Med, 13, e00113. https://doi.org/10.1016/j.plabm.2018.e00113.CrossRefPubMed

Trzybulska, D., Vergadi, E., & Tsatsanis, C. (2018). miRNA and other non-coding RNAs as promising diagnostic markers. Ejifcc, 29(3), 221–226.PubMedPubMedCentral

Krishnan, P., & Damaraju, S. (2018). The challenges and opportunities in the clinical application of noncoding RNAs: the road map for miRNAs and piRNAs in cancer diagnostics and prognostics. Int J Genomics, 2018, 5848046. https://doi.org/10.1155/2018/5848046.CrossRefPubMedPubMedCentral

10.

Zhang, Y., Liu, W., Li, R., Gu, J., Wu, P., Peng, C., et al. (2018). Structural insights into the sequence-specific recognition of Piwi by Drosophila Papi. Proceedings of the National Academy of Sciences of the United States of America, 115(13), 3374–3379. https://doi.org/10.1073/pnas.1717116115.CrossRefPubMedPubMedCentral

11.

Goriaux, C., Desset, S., Renaud, Y., Vaury, C., & Brasset, E. (2014). Transcriptional properties and splicing of the flamenco piRNA cluster. EMBO Reports, 15(4), 411–418. https://doi.org/10.1002/embr.201337898.CrossRefPubMedPubMedCentral

12.

Andersen, P. R., Tirian, L., Vunjak, M., & Brennecke, J. (2017). A heterochromatin-dependent transcription machinery drives piRNA expression. Nature, 549(7670), 54–59. https://doi.org/10.1038/nature23482.CrossRefPubMedPubMedCentral

13.

Dennis, C., Zanni, V., Brasset, E., Eymery, A., Zhang, L., Mteirek, R., Jensen, S., Rong, Y. S., & Vaury, C. (2013). “Dot COM”, a nuclear transit center for the primary piRNA pathway in Drosophila. PLoS One, 8(9), e72752. https://doi.org/10.1371/journal.pone.0072752.CrossRefPubMedPubMedCentral

14.

Dennis, C., Brasset, E., & Vaury, C. (2019). flam piRNA precursors channel from the nucleus to the cytoplasm in a temporally regulated manner along Drosophila oogenesis. Mob DNA, 10, 28. https://doi.org/10.1186/s13100-019-0170-7.CrossRefPubMedPubMedCentral

15.

Murota, Y., Ishizu, H., Nakagawa, S., Iwasaki, Y. W., Shibata, S., Kamatani, M. K., Saito, K., Okano, H., Siomi, H., & Siomi, M. C. (2014). Yb integrates piRNA intermediates and processing factors into perinuclear bodies to enhance piRISC assembly. Cell Reports, 8(1), 103–113. https://doi.org/10.1016/j.celrep.2014.05.043.CrossRefPubMed

16.

Szakmary, A., Reedy, M., Qi, H., & Lin, H. (2009). The Yb protein defines a novel organelle and regulates male germline stem cell self-renewal in Drosophila melanogaster. The Journal of Cell Biology, 185(4), 613–627. https://doi.org/10.1083/jcb.200903034.CrossRefPubMedPubMedCentral

17.

Pandey, R. R., Homolka, D., Chen, K. M., Sachidanandam, R., Fauvarque, M. O., & Pillai, R. S. (2017). Recruitment of Armitage and Yb to a transcript triggers its phased processing into primary piRNAs in Drosophila ovaries. PLoS Genetics, 13(8), e1006956. https://doi.org/10.1371/journal.pgen.1006956.CrossRefPubMedPubMedCentral

18.

Ge, D. T., Wang, W., Tipping, C., Gainetdinov, I., Weng, Z., & Zamore, P. D. (2019). The RNA-binding ATPase, Armitage, couples piRNA amplification in Nuage to phased piRNA production on mitochondria. Molecular Cell, 74(5), 982–995 e986. https://doi.org/10.1016/j.molcel.2019.04.006.CrossRefPubMedPubMedCentral

19.

Munafo, M., Manelli, V., Falconio, F. A., Sawle, A., Kneuss, E., Eastwood, E. L., et al. (2019). Daedalus and Gasz recruit Armitage to mitochondria, bringing piRNA precursors to the biogenesis machinery. Genes & Development, 33(13–14), 844–856. https://doi.org/10.1101/gad.325662.119.CrossRef

20.

Ipsaro, J. J., Haase, A. D., Knott, S. R., Joshua-Tor, L., & Hannon, G. J. (2012). The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis. Nature, 491(7423), 279–283. https://doi.org/10.1038/nature11502.CrossRefPubMedPubMedCentral

21.

Izumi, N., Shoji, K., Sakaguchi, Y., Honda, S., Kirino, Y., Suzuki, T., Katsuma, S., & Tomari, Y. (2016). Identification and functional analysis of the pre-piRNA 3′ trimmer in silkworms. Cell, 164(5), 962–973. https://doi.org/10.1016/j.cell.2016.01.008.CrossRefPubMedPubMedCentral

22.

Hirakata, S., Ishizu, H., Fujita, A., Tomoe, Y., & Siomi, M. C. (2019). Requirements for multivalent Yb body assembly in transposon silencing in Drosophila. EMBO Rep, 20(7), e47708. https://doi.org/10.15252/embr.201947708.CrossRefPubMed

23.

Ishizu, H., Kinoshita, T., Hirakata, S., Komatsuzaki, C., & Siomi, M. C. (2019). Distinct and collaborative functions of Yb and Armitage in transposon-targeting piRNA biogenesis. Cell Rep, 27(6), 1822-1835.e1828. https://doi.org/10.1016/j.celrep.2019.04.029.CrossRef

24.

Cheng, J., Guo, J. M., Xiao, B. X., Miao, Y., Jiang, Z., Zhou, H., et al. (2011). piRNA, the new non-coding RNA, is aberrantly expressed in human cancer cells. Clinica Chimica Acta, 412(17–18), 1621–1625. https://doi.org/10.1016/j.cca.2011.05.015.CrossRef

25.

Lin, X., Xia, Y., Hu, D., Mao, Q., Yu, Z., Zhang, H., et al. (2019). Transcriptomewide piRNA profiling in human gastric cancer. Oncology Reports. https://doi.org/10.3892/or.2019.7073.

26.

Martinez, V. D., Enfield, K. S. S., Rowbotham, D. A., & Lam, W. L. (2016). An atlas of gastric PIWI-interacting RNA transcriptomes and their utility for identifying signatures of gastric cancer recurrence. Gastric Cancer, 19(2), 660–665. https://doi.org/10.1007/s10120-015-0487-y.CrossRefPubMed

27.

Lin, X., Xia, Y., Hu, D., Mao, Q., Yu, Z., Zhang, H., Li, C., Chen, G., Liu, F., Zhu, W., Shi, Y., Zhang, H., Zheng, J., Sun, T., Xu, J., Chao, H. H., Zheng, X., & Luο, X. (2019). Transcriptomewide piRNA profiling in human gastric cancer. Oncology Reports, 41(5), 3089–3099. https://doi.org/10.3892/or.2019.7073.CrossRefPubMedPubMedCentral

28.

Cui, L., Lou, Y., Zhang, X., Zhou, H., Deng, H., Song, H., Yu, X., Xiao, B., Wang, W., & Guo, J. (2011). Detection of circulating tumor cells in peripheral blood from patients with gastric cancer using piRNAs as markers. Clinical Biochemistry, 44(13), 1050–1057. https://doi.org/10.1016/j.clinbiochem.2011.06.004.CrossRefPubMed

29.

Cheng, J., Deng, H., Xiao, B., Zhou, H., Zhou, F., Shen, Z., & Guo, J. (2012). piR-823, a novel non-coding small RNA, demonstrates in vitro and in vivo tumor suppressive activity in human gastric cancer cells. Cancer Letters, 315(1), 12–17. https://doi.org/10.1016/j.canlet.2011.10.004.CrossRefPubMed

30.

Wang, Y., Liu, Y., Shen, X., Zhang, X., Chen, X., Yang, C., & Gao, H. (2012). The PIWI protein acts as a predictive marker for human gastric cancer. International Journal of Clinical and Experimental Pathology, 5(4), 315–325.PubMedPubMedCentral

31.

Gao, C. L., Sun, R., Li, D. H., & Gong, F. (2018). PIWI-like protein 1 upregulation promotes gastric cancer invasion and metastasis. Onco Targets Ther, 11, 8783–8789. https://doi.org/10.2147/OTT.S186827.CrossRefPubMedPubMedCentral

32.

Araujo, T., Khayat, A., Quintana, L., Calcagno, D., Mourao, R., Modesto, A., et al. (2018). Piwi like RNA-mediated gene silencing 1 gene as a possible major player in gastric cancer. World Journal of Gastroenterology, 24(47), 5338–5350. https://doi.org/10.3748/wjg.v24.i47.5338.CrossRefPubMedPubMedCentral

33.

Hashim, A., Rizzo, F., Marchese, G., Ravo, M., Tarallo, R., Nassa, G., et al. (2014). RNA sequencing identifies specific PIWI-interacting small non-coding RNA expression patterns in breast cancer. Oncotarget, 5(20), 9901–9910. https://doi.org/10.18632/oncotarget.2476.CrossRefPubMedPubMedCentral

34.

Krishnan, P., Ghosh, S., Graham, K., Mackey, J. R., Kovalchuk, O., & Damaraju, S. (2016). Piwi-interacting RNAs and PIWI genes as novel prognostic markers for breast cancer. Oncotarget, 7(25), 37944–37956. https://doi.org/10.18632/oncotarget.9272.CrossRefPubMedPubMedCentral

35.

Huang, G., Hu, H., Xue, X., Shen, S., Gao, E., Guo, G., Shen, X., & Zhang, X. (2013). Altered expression of piRNAs and their relation with clinicopathologic features of breast cancer. Clinical & Translational Oncology, 15(7), 563–568. https://doi.org/10.1007/s12094-012-0966-0.CrossRef

36.

Oner, C., Turgut Cosan, D., & Colak, E. (2016). Estrogen and androgen hormone levels modulate the expression of PIWI interacting RNA in prostate and breast cancer. PLoS One, 11(7), e0159044. https://doi.org/10.1371/journal.pone.0159044.CrossRefPubMedPubMedCentral

37.

Tan, L., Mai, D., Zhang, B., Jiang, X., Zhang, J., Bai, R., Ye, Y., Li, M., Pan, L., Su, J., Zheng, Y., Liu, Z., Zuo, Z., Zhao, Q., Li, X., Huang, X., Yang, J., Tan, W., Zheng, J., & Lin, D. (2019). PIWI-interacting RNA-36712 restrains breast cancer progression and chemoresistance by interaction with SEPW1 pseudogene SEPW1P RNA. Molecular Cancer, 18(1), 1–15. https://doi.org/10.1186/s12943-019-0940-3.CrossRef

38.

Fu, A., Jacobs, D. I., Hoffman, A. E., Zheng, T., & Zhu, Y. (2015). PIWI-interacting RNA 021285 is involved in breast tumorigenesis possibly by remodeling the cancer epigenome. Carcinogenesis, 36(10), 1094–1102. https://doi.org/10.1093/carcin/bgv105.CrossRefPubMedPubMedCentral

39.

Zhang, H., Ren, Y., Xu, H., Pang, D., Duan, C., & Liu, C. (2013). The expression of stem cell protein Piwil2 and piR-932 in breast cancer. Surgical Oncology, 22(4), 217–223. https://doi.org/10.1016/j.suronc.2013.07.001.CrossRefPubMed

40.

Litwin, M., Szczepanska-Buda, A., Michalowska, D., Grzegrzolka, J., Piotrowska, A., Gomulkiewicz, A., et al. (2018). Aberrant expression of PIWIL1 and PIWIL2 and their clinical significance in ductal breast carcinoma. Anticancer Res, 38(4), 2021–2030. https://doi.org/10.21873/anticanres.12441.CrossRefPubMed

41.

Heng, Z. S. L., Lee, J. Y., Subhramanyam, C. S., Wang, C., Thanga, L. Z., & Hu, Q. (2018). The role of 17betaestradiolinduced upregulation of Piwilike 4 in modulating gene expression and motility in breast cancer cells. Oncology Reports, 40(5), 2525–2535. https://doi.org/10.3892/or.2018.6676.CrossRefPubMedPubMedCentral

42.

Li, Y., Wu, X., Gao, H., Jin, J. M., Li, A. X., Kim, Y. S., Pal, S. K., Nelson, R. A., Lau, C. M., Guo, C., Mu, B., Wang, J., Wang, F., Wang, J., Zhao, Y., Chen, W., Rossi, J. J., Weiss, L. M., & Wu, H. (2015). Piwi-interacting RNAs (piRNAs) are dysregulated in renal cell carcinoma and associated with tumor metastasis and cancer-specific survival. Molecular Medicine, 21, 381–388. https://doi.org/10.2119/molmed.2014.00203.CrossRefPubMedPubMedCentral

43.

Busch, J., Ralla, B., Jung, M., Wotschofsky, Z., Trujillo-Arribas, E., Schwabe, P., Kilic, E., Fendler, A., & Jung, K. (2015). Piwi-interacting RNAs as novel prognostic markers in clear cell renal cell carcinomas. Journal of Experimental & Clinical Cancer Research, 34, 61–11. https://doi.org/10.1186/s13046-015-0180-3.CrossRef

44.

Zhao, C., Tolkach, Y., Schmidt, D., Toma, M., Muders, M. H., Kristiansen, G., Müller, S. C., & Ellinger, J. (2019). Mitochondrial PIWI-interacting RNAs are novel biomarkers for clear cell renal cell carcinoma. World Journal of Urology, 37(8), 1639–1647. https://doi.org/10.1007/s00345-018-2575-1.CrossRefPubMed

45.

Iliev, R., Stanik, M., Fedorko, M., Poprach, A., Vychytilova-Faltejskova, P., Slaba, K., Svoboda, M., Fabian, P., Pacik, D., Dolezel, J., & Slaby, O. (2016). Decreased expression levels of PIWIL1, PIWIL2, and PIWIL4 are associated with worse survival in renal cell carcinoma patients. Onco Targets Ther, 9, 217–222. https://doi.org/10.2147/OTT.S91295.CrossRefPubMedPubMedCentral

46.

Iliev, R., Fedorko, M., Machackova, T., Mlcochova, H., Svoboda, M., Pacik, D., et al. (2016). Expression levels of PIWI-interacting RNA, piR-823, are deregulated in tumor tissue, blood serum and urine of patients with renal cell carcinoma. Anticancer Res, 36(12), 6419–6423. https://doi.org/10.21873/anticanres.11239.CrossRefPubMed

47.

Stohr, C. G., Steffens, S., Polifka, I., Jung, R., Kahlmeyer, A., Ivanyi, P., et al. (2019). Piwi-like 1 protein expression is a prognostic factor for renal cell carcinoma patients. Scientific Reports, 9(1), 1741. https://doi.org/10.1038/s41598-018-38254-3.CrossRefPubMedPubMedCentral

48.

Mai, D., Ding, P., Tan, L., Zhang, J., Pan, Z., Bai, R., Li, C., Li, M., Zhou, Y., Tan, W., Zhou, Z., Li, Y., Zhou, A., Ye, Y., Pan, L., Zheng, Y., Su, J., Zuo, Z., Liu, Z., Zhao, Q., Li, X., Huang, X., Li, W., Wu, S., Jia, W., Zou, S., Wu, C., Xu, R. H., Zheng, J., & Lin, D. (2018). PIWI-interacting RNA-54265 is oncogenic and a potential therapeutic target in colorectal adenocarcinoma. Theranostics, 8(19), 5213–5230. https://doi.org/10.7150/thno.28001.CrossRefPubMedPubMedCentral

49.

Yin, J., Jiang, X. Y., Qi, W., Ji, C. G., Xie, X. L., Zhang, D. X., Cui, Z. J., Wang, C. K., Bai, Y., Wang, J., & Jiang, H. Q. (2017). piR-823 contributes to colorectal tumorigenesis by enhancing the transcriptional activity of HSF1. Cancer Science, 108(9), 1746–1756. https://doi.org/10.1111/cas.13300.CrossRefPubMedPubMedCentral

50.

Yin, J., Qi, W., Ji, C. G., Zhang, D. X., Xie, X. L., Ding, Q., Jiang, X. Y., Han, J., & Jiang, H. Q. (2019). Small RNA sequencing revealed aberrant piRNA expression profiles in colorectal cancer. Oncology Reports, 42(1), 263–272. https://doi.org/10.3892/or.2019.7158.CrossRefPubMed

51.

Weng, W., Liu, N., Toiyama, Y., Kusunoki, M., Nagasaka, T., Fujiwara, T., Wei, Q., Qin, H., Lin, H., Ma, Y., & Goel, A. (2018). Novel evidence for a PIWI-interacting RNA (piRNA) as an oncogenic mediator of disease progression, and a potential prognostic biomarker in colorectal cancer. Molecular Cancer, 17(1), 16. https://doi.org/10.1186/s12943-018-0767-3.CrossRefPubMedPubMedCentral

52.

Sun, R., Gao, C. L., Li, D. H., Li, B. J., & Ding, Y. H. (2017). Expression status of PIWIL1 as a prognostic marker of colorectal cancer. Disease Markers, 2017, 1204937. https://doi.org/10.1155/2017/1204937.CrossRefPubMedPubMedCentral

53.

Vychytilova-Faltejskova, P., Stitkovcova, K., Radova, L., Sachlova, M., Kosarova, Z., Slaba, K., et al. (2018). Circulating PIWI-interacting RNAs piR-5937 and piR-28876 are promising diagnostic biomarkers of colon cancer. Cancer Epidemiology, Biomarkers & Prevention, 27(9), 1019–1028. https://doi.org/10.1158/1055-9965.EPI-18-0318.CrossRef

54.

Tian, T., Li, X., & Zhang, J. (2019). mTOR signaling in cancer and mTOR inhibitors in solid tumor targeting therapy. International Journal of Molecular Sciences, 20(3). https://doi.org/10.3390/ijms20030755.

55.

Peng, L., Song, L., Liu, C., Lv, X., Li, X., Jie, J., Zhao, D., & Li, D. (2016). piR-55490 inhibits the growth of lung carcinoma by suppressing mTOR signaling. Tumour Biology, 37(2), 2749–2756. https://doi.org/10.1007/s13277-015-4056-0.CrossRefPubMed

56.

Yao, J., Wang, Y. W., Fang, B. B., Zhang, S. J., & Cheng, B. L. (2016). piR-651 and its function in 95-D lung cancer cells. Biomed Rep, 4(5), 546–550. https://doi.org/10.3892/br.2016.628.CrossRefPubMedPubMedCentral

57.

Zhang, S. J., Yao, J., Shen, B. Z., Li, G. B., Kong, S. S., Bi, D. D., Pan, S. H., & Cheng, B. L. (2018). Role of piwi-interacting RNA-651 in the carcinogenesis of non-small cell lung cancer. Oncology Letters, 15(1), 940–946. https://doi.org/10.3892/ol.2017.7406.CrossRefPubMed

58.

Li, D., Luo, Y., Gao, Y., Yang, Y., Wang, Y., Xu, Y., Tan, S., Zhang, Y., Duan, J., & Yang, Y. (2016). piR-651 promotes tumor formation in non-small cell lung carcinoma through the upregulation of cyclin D1 and CDK4. International Journal of Molecular Medicine, 38(3), 927–936. https://doi.org/10.3892/ijmm.2016.2671.CrossRefPubMed

59.

Reeves, M. E., Firek, M., Jliedi, A., & Amaar, Y. G. (2017). Identification and characterization of RASSF1C piRNA target genes in lung cancer cells. Oncotarget, 8(21), 34268–34282. https://doi.org/10.18632/oncotarget.15965.CrossRefPubMedPubMedCentral

60.

Reeves, M. E., Baldwin, M. L., Aragon, R., Baldwin, S., Chen, S. T., Li, X., Mohan, S., & Amaar, Y. G. (2012). RASSF1C modulates the expression of a stem cell renewal gene, PIWIL1. BMC Research Notes, 5, 239. https://doi.org/10.1186/1756-0500-5-239.CrossRefPubMedPubMedCentral

61.

Reeves, M. E., Firek, M., Chen, S. T., & Amaar, Y. G. (2014). Evidence that RASSF1C stimulation of lung cancer cell proliferation depends on IGFBP-5 and PIWIL1 expression levels. PLoS One, 9(7), e101679. https://doi.org/10.1371/journal.pone.0101679.CrossRefPubMedPubMedCentral

62.

Xie, K., Zhang, K., Kong, J., Wang, C., Gu, Y., Liang, C., Jiang, T., Qin, N., Liu, J., Guo, X., Huo, R., Liu, M., Ma, H., Dai, J., & Hu, Z. (2018). Cancer-testis gene PIWIL1 promotes cell proliferation, migration, and invasion in lung adenocarcinoma. Cancer Medicine, 7(1), 157–166. https://doi.org/10.1002/cam4.1248.CrossRefPubMed

Titel: piRNAs: biogenesis and their potential roles in cancer
verfasst von: Binghong Guo
Dongpei Li
Likun Du
Xiao Zhu
Publikationsdatum: 20.01.2020
Verlag: Springer US
Erschienen in: Cancer and Metastasis Reviews / Ausgabe 2/2020
Print ISSN: 0167-7659
Elektronische ISSN: 1573-7233
DOI: https://doi.org/10.1007/s10555-020-09863-0

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piRNAs: biogenesis and their potential roles in cancer

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