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Cardiovascular Drugs and Therapy
Erschienen in: Cardiovascular Drugs and Therapy 3/2014

01.06.2014 | REVIEW ARTICLE

Galectin-3: A Modifiable Risk Factor in Heart Failure

verfasst von: Rudolf A. de Boer, A. Rogier van der Velde, Christian Mueller, Dirk J. van Veldhuisen, Stefan D. Anker, W. Frank Peacock, Kirkwood F. Adams, Alan Maisel

Erschienen in: Cardiovascular Drugs and Therapy | Ausgabe 3/2014

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Abstract

Myocardial galectin-3 is upregulated upon cardiac stressors such as angiotensin II and pressure overload leading to cardiac remodeling and heart failure. The expression level of galectin-3 mirrors the progression and severity of heart failure and therefore, galectin-3 is being used as a biomarker for heart failure. However, as galectin-3 is causally involved in pathological myocardial fibrosis it has been suggested that galectin-3 also actively contributes to heart failure development. In this review we discuss how galectin-3 could be a target for therapy in heart failure. Currently, attempts are being made to target or inhibit galectin-3 using natural or pharmaceutical inhibitors with the aim to ameliorate heart failure. Available experimental evidence suggests that galectin-3 inhibition indeed may represent a novel tool to treat heart failure. A strong interaction with aldosterone, another strong pro-fibrotic factor, has been described. Clinical studies are needed to prove if galectin-3 may be used to install specific treatment regimens.
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Metadaten
Titel
Galectin-3: A Modifiable Risk Factor in Heart Failure
verfasst von
Rudolf A. de Boer
A. Rogier van der Velde
Christian Mueller
Dirk J. van Veldhuisen
Stefan D. Anker
W. Frank Peacock
Kirkwood F. Adams
Alan Maisel
Publikationsdatum
01.06.2014
Verlag
Springer US
Erschienen in
Cardiovascular Drugs and Therapy / Ausgabe 3/2014
Print ISSN: 0920-3206
Elektronische ISSN: 1573-7241
DOI
https://doi.org/10.1007/s10557-014-6520-2

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