nach oben

Digestive Diseases and Sciences

Erschienen in:

01.12.2007 | Review Article

Sarcoidosis of Gastrointestinal Tract: A Rare Disease

verfasst von: Bobbak Vahid, Maya Spodik, Kristine N. Braun, Leyla J. Ghazi, Ali Esmaili

Erschienen in: Digestive Diseases and Sciences | Ausgabe 12/2007

Einloggen, um Zugang zu erhalten

Abstract

Gastrointestinal (GI) tract sarcoidosis is an uncommon form of sarcoidosis. The GI tract can be involved as an isolated disease as a part of systemic sarcoidosis. Clinical manifestations of esophageal, gastric, small bowel, colon, and appendicular sarcoidosis are discussed in this review. The differential diagnosis of GI sarcoidosis is extensive. Other granulomatous diseases of the GI tract, like tuberculosis, fungal infections, parasitic diseases, inflammatory bowel disease, and Whipple’s disease, should be excluded before making the diagnosis of GI sarcoidosis. Corticosteroid therapy is effective in treatment of GI sarcoidosis. Surgical intervention may be necessary in patients with bowel obstruction, perforation, or massive hemorrhage.

Ricker W, Clark M (1949) Sarcoidosis: a clinicopathologic review of three hundred cases, including twenty-two autopsies. J Clin Pathol 19:725–749

Longcope WT, Freiman DG (1952) A study of sarcoidosis. Medicine 31:1–132PubMedCrossRef

Engle RL Jr (1953) Sarcoid and sarcoid-like granulomas. A study of twenty-seven post-mortem examinations. Am J Pathol 29:53–69PubMed

Maylock LR, Bertrand P, Morrison CE, Scott JH (1963) Manifestations of sarcoidosis. Am J Med 35:67–89CrossRef

Palmer CD (1958) Note on silent sarcoidosis of the gastric mucosa. J Lab Clin Med 52:231–234PubMed

Iwai K, Tachibana T, Hosoda Y, Matsui Y (1988) Sarcoidosis autopsies in Japan. Frequency and trend in the last 28 years. Sarcoidosis 5:60–65PubMed

Israel HL, Sones M (1953) Sarcoidosis: clinical observation on one hundred sixty cases. Arch Intern Med 102:766–776

McCormik PA, Feighery C, Dolan C, O’Farrelly C, Kelliher P, Graeme-Cook F et al (1998) Altered gastrointestinal immune response in sarcoidosis. Gut 29:1628–1631CrossRef

Papadopoulos KI, Sjöberg K, Lindgren S, Hallengren B (1999) Evidence of gastrointestinal immune activity in patients with sarcoidosis. J Intern Med 245:525–531PubMedCrossRef

10.

Lukens FJ, Machicao VI, Woodward TA, DeVault KR (2002) Esophageal sarcoidosis: an unusual diagnosis. J Clin Gastroenterol 34:54–56PubMedCrossRef

11.

Levine MS, Ekberg O, Rubesin SE, Gatenby RA (1989) Gastrointestinal sarcoidosis: radiographic findings. Am J Roentgenol 153:293–295

12.

Siegel CI, Honda M, Salik J et al (1961) Dysphagia due to granulomatous myositis of the cricopharyngeus muscle: physiological and cineradiographic studies prior to and following successful surgical therapy. Trans Assoc Am Physicians 74:342–352PubMed

13.

Cook DM, Dines DE, Dycus DS (1970) Sarcoidosis: report of a case presenting as dysphagia. Chest 57:84–86PubMedCrossRef

14.

Hardy WE, Tulgan H, Haidak G et al (1967) Sarcoidosis: a case presenting with dysphagia and dysphonia. Ann Intern Med 66:353–357PubMed

15.

Cappell MS (1995) Endoscopic, radiographic, and manometric findings in dysphagia associated with sarcoid due to extrinsic esophageal compression from subcarinal lymphadenopathy. Am J Gastroenterol 90:489–492PubMed

16.

Polachek AA, Matre WJ (1964) Gastrointestinal sarcoidosis: report of a case involving the esophagus. Am J Dig Dis 9:429PubMedCrossRef

17.

Wiesner PJ, Kleinman MS, Condemi JJ et al (1971) Sarcoidosis of esophagus. Am J Dig Dis 16:943–951PubMedCrossRef

18.

Dufrense CR, Jeyasingham K, Baker KK (1983) Achalasia of the cardia associated with pulmonary sarcoidosis. Surgery 94:32–35

19.

Aronson PJ, Fretzin DF, Morgan NE (1985) A unique case of sarcoidosis with coexistent collagen vascular disease. Possible result of a compatible disease-sustaining immunologic environment. J Am Acad Dermatol 13:886–891PubMedCrossRef

20.

Nidiry JJ, Mines S, Hackney R et al (1991) Sarcoidosis: a unique presentation of dysphagia, myopathy, and photophobia. Am J Gastroenterol 86:1679–1682PubMed

21.

Boruchowicz A, Canva-Celcambre V, Guillemot F et al (1996) Sarcoidosis and achalasia: a fortuitous association? Am J Gastroenterol 91:413–414PubMed

22.

Gallagher P, Harris M, Turnbull FW, Turner L (1984) Gastric sarcoidosis. J Roy Society Med 77:837–839

23.

Chinitz MA, Brandt LJ, Frank MS, Frager D, Sablay L (1985) Symptomatic sarcoidosis of the stomach. Dig Dis Sci 30:682–688PubMedCrossRef

24.

Ona FV (1981) Gastric sarcoid: unusual cause of upper gastrointestinal hemorrhage. Am J Gastroenterol 75:286–288PubMed

25.

Kaneki T, Kizumi T, Yamamoto H, Yamaguchi S, Hachiya T, Kubo K et al (2001) Gastric sarcoidosis—a single polypoid appearance in the involvement. Hepatogastroenterology 48:1209–1210PubMed

26.

Roth D, West B, Madison J, Cooper D (1994) Gastric carcinoma in a patient with sarcoidosis of the gastrointestinal tract. Am J Gastroenterol 89:1589–1591PubMed

27.

Kremer RM, William JS (1970) Gastric sarcoidosis: a difficult diagnosis. Am Surg 36:686–690PubMed

28.

Panella VS, Katz S, Kahn E, Ulberg R (1988) Isolated gastric sarcoidosis. Unique remnant of disseminated disease. J Clin Gastroenterol 10:327–331PubMedCrossRef

29.

Konda J, Ruth M, Sassaris M, Hunter FM (1980) Sarcoidosis of stomach and rectum. Am J Gastroenterol 73:516–518PubMed

30.

Newton C, Nochomovitz L, Sackier JM (1998) Gastric adenocarcinoma associated with isolated granulomatous gastritis. Ann Surg Oncol 5:407–410PubMedCrossRef

31.

Apell AA (1951) Pyloric obstruction due to sarcoid of the stomach. Arch Surg 62:140–144

32.

Scott NM, Smith VM, Cox PA (1953) Sarcoid and sarcoid-like lesions of the alimentary tract. Arch Intern Med 92:741–749

33.

MacRury SM, McQuaker G, Morton R, Hume R (1992) sarcoidosis: Association with small bowel disease and folate deficiency. J Clin Pathol 45:823–825PubMedCrossRef

34.

Fleming RH, Nuzek M, McFadden DW (1994) Small intestinal sarcoidosis with massive hemorrhage: report of a case. Surgery 115:127–131PubMed

35.

Sprague R, Harper P, McClain S, Trainer T, Beeken W (1984) Disseminated gastrointestinal sarcoidosis. Case report and review of the literature. Gastroenterology 87:421–425PubMed

36.

Bulger K, O’Riodaron M, Purdy S, O’Brien M, Lennon J (1988) Gastrointestinal sarcoidosis resembling Crohn’s disease. Am J Gastroenterol 83:1415–1417PubMed

37.

Douglas JG, Gillon J, Logan RF, Grant IW, Crompton GK (1984) Sarcoidosis and celiac disease: an association? Lancet 2:13–15PubMedCrossRef

38.

Lindgren A, Engstrom CP, Nilsson O, Abrahamsson H (1995) Protein-losing enteropathy in an unusual form of sarcoidosis. Eur J Gastroenterol Hepatol 7:1005–1007PubMedCrossRef

39.

Godeau B, Farcet JP, Delchier JC, Xuan DH, Chaumette MT, Gaulard P (1992) Protein-losing enteropathy in gastrointestinal sarcoidosis associated with malignant lymphoma. J Clin Gastroenterol 14:78–80PubMedCrossRef

40.

Popovic OS, Brkic S, Bojic P, Kenic V Jojic N, Djuric V, et al (1980) Sarcoidosis and protein-losing enteropathy. Gastroenterology 78:119–125PubMed

41.

Stampfl DA, Grim IS, Barbot DJ, Rosato FE, Gordon SJ (1990) Sarcoidosis causing duodenal obstruction. Case report and review of gastrointestinal manifestations. Dig Dis Sci 35:526–532PubMedCrossRef

42.

Noël JM, Katona IM, Piñeiro-Carrero VM (1997) Sarcoidosis resulting in duodenal obstruction in an adolescent. J Pediatr Gastroenterol Nutr 24:594–598PubMedCrossRef

43.

Tobi M, Kobrin I, Ariel I (1982) Rectal involvement in sarcoidosis. Dis Col Rectum 25:491–493CrossRef

44.

Nchimi A, Francotte N, Rausin L, Khamis J (2003) Ileocecal sarcoidosis. Radiology 228:452–455PubMedCrossRef

45.

Beniwal RS, Cummings OW, Cho WK (2003) Symptomatic Gastrointestinal Sarcoidosis; Case report and review of the literature. Dig Dis Sci 48:174–178PubMedCrossRef

46.

Veitch AM, Badger I (2004) Sarcoidosis presenting as colonic polyposis: report of a case. Dis Colon Rectum 47:937–939PubMedCrossRef

47.

Zech JR, Kroger E, Bonnin AJ, Richmond GW (1993) Sarcoidosis: unusual cause of a rectal mass. South Med J 86:1054–1055PubMed

48.

Healy V, Jeffers M, Keane FBV, Tucker ON (2003) Granulomatous appendicitis. J Roy Coll Surg Edinb 1:286–289

49.

Collins DCS (1995) A study of 50,000 specimens of the human vermiform appendix. Surg Gynecol Obstet 101:437–445

50.

Tinker MA, Viswanathan B, Laufer H, Margolis IB (1984) Acute appendicitis and pernicious anemia as complications of gastrointestinal sarcoidosis. Am J Gastroenterol 79:868–872PubMed

51.

Macleod JB (1965) Sarcoidosis involving the vermiform appendix. J Roy Coll Surg Edinb 10:319–323

52.

Munt PW (1974) Sarcoidosis of the appendix presenting as appendiceal perforation and abscess. Chest 66:295–297PubMedCrossRef

53.

Sachar DB, Rochester J (2004) The myth of gastrointestinal sarcoidosis: a case of guilt by association. Inflamm Bowel Dis 10:441–443PubMedCrossRef

Titel: Sarcoidosis of Gastrointestinal Tract: A Rare Disease
verfasst von: Bobbak Vahid
Maya Spodik
Kristine N. Braun
Leyla J. Ghazi
Ali Esmaili
Publikationsdatum: 01.12.2007
Verlag: Springer US
Erschienen in: Digestive Diseases and Sciences / Ausgabe 12/2007
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-006-9448-y

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

Positiver FIT: Die Ursache liegt nicht immer im Dickdarm

27.05.2024 Blut im Stuhl Nachrichten

Immunchemischer Stuhltest positiv, Koloskopie negativ – in solchen Fällen kann die Blutungsquelle auch weiter proximal sitzen. Ein Forschungsteam hat nachgesehen, wie häufig und in welchen Lokalisationen das der Fall ist.

GLP-1-Agonisten können Fortschreiten diabetischer Retinopathie begünstigen

24.05.2024 Diabetische Retinopathie Nachrichten

Möglicherweise hängt es von der Art der Diabetesmedikamente ab, wie hoch das Risiko der Betroffenen ist, dass sich sehkraftgefährdende Komplikationen verschlimmern.

Mehr Lebenszeit mit Abemaciclib bei fortgeschrittenem Brustkrebs?

24.05.2024 Mammakarzinom Nachrichten

In der MONARCHE-3-Studie lebten Frauen mit fortgeschrittenem Hormonrezeptor-positivem, HER2-negativem Brustkrebs länger, wenn sie zusätzlich zu einem nicht steroidalen Aromatasehemmer mit Abemaciclib behandelt wurden; allerdings verfehlte der numerische Zugewinn die statistische Signifikanz.

ADT zur Radiatio nach Prostatektomie: Wenn, dann wohl länger

24.05.2024 Prostatakarzinom Nachrichten

Welchen Nutzen es trägt, wenn die Strahlentherapie nach radikaler Prostatektomie um eine Androgendeprivation ergänzt wird, hat die RADICALS-HD-Studie untersucht. Nun liegen die Ergebnisse vor. Sie sprechen für länger dauernden Hormonentzug.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 12/2007

Apolipoprotein E Gene Polymorphism in Nonalcoholic Fatty Liver Disease

Superior Vena Cava Syndrome Associated with the Metastasis of Gastric Adenocarcinoma to Cervical Lymph Nodes

Vitiligo Improvement in a Hepatitis C Patient After Treatment With PEG-Interferon α-2A and Ribavirin: A Case Report

A Rare Association of Primary Biliary Cirrhosis With Antiphopholipid Antibody Syndrome

Infliximab Delays but Does Not Avoid the Need for Surgery in Treatment-Resistant Pediatric Crohn’ Disease