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Digestive Diseases and Sciences

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01.01.2010 | Original Article

Infection by CagA-Positive Helicobacter pylori Strains may Contribute to Alter the Sperm Quality of Men with Fertility Disorders and Increase the Systemic Levels of TNF-α

verfasst von: Giulia Collodel, Elena Moretti, Maria Stella Campagna, Serena Capitani, Cristina Lenzi, Natale Figura

Erschienen in: Digestive Diseases and Sciences | Ausgabe 1/2010

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Abstract

This study was aimed to address the possibility that Helicobacter pylori infection may play a detrimental role in semen quality of men with idiopathic infertility. Infection by H. pylori and by strains expressing CagA was determined in 80 male infertile patients by Western blotting and ELISA. Semen analysis was performed by light microscopy and transmission electron microscopy quantitatively elaborated (fertility index, immaturity, necrosis, and apoptosis percentages). Systemic levels of IL-6 and TNF-α were evaluated. Infertile patients infected with H. pylori showed a low sperm quality respective to uninfected patients. Particularly, in CagA-positive patients we observed a significant reduction in sperm motility and in the fertility index, while apoptosis and necrosis were increased. In these patients, the means of systemic TNF-α levels were higher than those of uninfected patients. The negative influence of CagA-positive H. pylori infection on sperm quality may help to understand the role of chronic infections in reproductive disorders.

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Titel: Infection by CagA-Positive Helicobacter pylori Strains may Contribute to Alter the Sperm Quality of Men with Fertility Disorders and Increase the Systemic Levels of TNF-α
verfasst von: Giulia Collodel
Elena Moretti
Maria Stella Campagna
Serena Capitani
Cristina Lenzi
Natale Figura
Publikationsdatum: 01.01.2010
Verlag: Springer US
Erschienen in: Digestive Diseases and Sciences / Ausgabe 1/2010
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-008-0704-1

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Infection by CagA-Positive Helicobacter pylori Strains may Contribute to Alter the Sperm Quality of Men with Fertility Disorders and Increase the Systemic Levels of TNF-α

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