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01.07.2012 | Original Article

Nutrition, Intestinal Permeability, and Blood Ethanol Levels Are Altered in Patients with Nonalcoholic Fatty Liver Disease (NAFLD)

verfasst von: Valentina Volynets, Markus A. Küper, Stefan Strahl, Ina B. Maier, Astrid Spruss, Sabine Wagnerberger, Alfred Königsrainer, Stephan C. Bischoff, Ina Bergheim

Erschienen in: Digestive Diseases and Sciences | Ausgabe 7/2012

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Abstract

Background

A role of an altered dietary pattern (e.g., a diet rich in sugar) but also alterations at the level of the intestinal barrier have repeatedly been discussed to be involved in the development and progression of nonalcoholic fatty liver disease (NAFLD).

Aims

To determine if the nutritional intake, intestinal flora, and permeability and the development of NAFLD are related in humans.

Methods

Ten controls and 20 patients with NAFLD ranging from simple steatosis to steatohepatitis were included in the study. Bacterial overgrowth, orocecal transit time, and intestinal permeability were assessed. Alcohol, endotoxin, and plasminogen activator inhibitor (PAI-) 1 concentration were determined in plasma. Nutritional intake was assessed using a dietary history.

Results

Despite no differences in the prevalence of bacterial overgrowth and in the orocecal transit time, intestinal permeability, alcohol, and endotoxin levels in plasma were significantly higher in patients with NAFLD than in controls. Similar results were also found for PAI-1 plasma concentrations. Patients with NAFLD had a significantly higher intake of protein, total carbohydrates, and mono- as well as disaccharides than controls. PAI-1, endotoxin, and ALT plasma levels were positively related to total protein and carbohydrate intake.

Conclusions

Taken together, our results indicate that intestinal permeability, endogenous alcohol synthesis, and nutritional intake are markedly altered in patients with NAFLD.

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Titel: Nutrition, Intestinal Permeability, and Blood Ethanol Levels Are Altered in Patients with Nonalcoholic Fatty Liver Disease (NAFLD)
verfasst von: Valentina Volynets
Markus A. Küper
Stefan Strahl
Ina B. Maier
Astrid Spruss
Sabine Wagnerberger
Alfred Königsrainer
Stephan C. Bischoff
Ina Bergheim
Publikationsdatum: 01.07.2012
Verlag: Springer US
Erschienen in: Digestive Diseases and Sciences / Ausgabe 7/2012
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-012-2112-9

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Nutrition, Intestinal Permeability, and Blood Ethanol Levels Are Altered in Patients with Nonalcoholic Fatty Liver Disease (NAFLD)