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Erschienen in:

01.08.2011

Elevated Th22 Cells Correlated with Th17 Cells in Patients with Rheumatoid Arthritis

verfasst von: Lei Zhang, Jian-min Li, Xin-guang Liu, Dao-xin Ma, Nai-wen Hu, Yong-gang Li, Wei Li, Yu Hu, Shuang Yu, Xun Qu, Mei-xiang Yang, A-lei Feng, Guang-hui Wang

Erschienen in: Journal of Clinical Immunology | Ausgabe 4/2011

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Abstract

Background

T-helper (Th) 22 and Th17 cells are implicated in the pathogenesis of autoimmune diseases. The roles of Th22 cells in the pathophysiology of rheumatoid arthritis (RA) remain unsettled.

Materials and Methods

CD4⁺IFNγ⁻IL17⁻IL-22⁺ T cells (Th22 cells), CD4⁺IFNγ⁻IL-22⁻IL17⁺ T cells (pure Th17 cells), CD4⁺IL17⁺ T cells (Th17 cells), and CD4⁺IFNγ⁺ T cells (Th1 cells) in RA, osteoarthritis patients, and healthy controls were examined by flow cytometry. Plasma IL-22 and IL-17 levels were examined by enzyme-linked immunosorbent assay.

Results

Th22 cells, pure Th17 cells, Th17 cells, and interleukin-22 were significantly elevated in RA patients compared with osteoarthritis and healthy controls, but there were no significant differences regarding Th1 cells and interleukin-17. Th22 cells showed a positive correlation with interleukin-22 as well as pure Th17 cells or Th17 cells in RA patients. Additionally, the percentages of Th22 cells, pure Th17 cells as well as Th17 cells correlated positively with both C-reactive protein levels and 28-joints disease activity score.

Conclusion

Together, our results indicated a possible role of Th22 pure Th17 cells and Th17 cells in RA, and blockade of the interleukin-22 may be a reasonable therapeutic strategy for RA.

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Titel: Elevated Th22 Cells Correlated with Th17 Cells in Patients with Rheumatoid Arthritis
verfasst von: Lei Zhang
Jian-min Li
Xin-guang Liu
Dao-xin Ma
Nai-wen Hu
Yong-gang Li
Wei Li
Yu Hu
Shuang Yu
Xun Qu
Mei-xiang Yang
A-lei Feng
Guang-hui Wang
Publikationsdatum: 01.08.2011
Verlag: Springer US
Erschienen in: Journal of Clinical Immunology / Ausgabe 4/2011
Print ISSN: 0271-9142
Elektronische ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-011-9540-8

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Abstract

Background

Materials and Methods

Results

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