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Erschienen in: Metabolic Brain Disease 1/2022

03.09.2021 | Review Article

Toxoplasmosis: Targeting neurotransmitter systems in psychiatric disorders

verfasst von: Tooran Nayeri, Shahabeddin Sarvi, Ahmad Daryani

Erschienen in: Metabolic Brain Disease | Ausgabe 1/2022

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Abstract

The most common form of the disease caused by Toxoplasma gondii (T. gondii) is latent toxoplasmosis due to the formation of tissue cysts in various organs, such as the brain. Latent toxoplasmosis is probably a risk factor in the development of some neuropsychiatric disorders. Behavioral changes after infection are caused by the host immune response, manipulation by the parasite, central nervous system (CNS) inflammation, as well as changes in hormonal and neuromodulator relationships. The present review focused on the exact mechanisms of T. gondii effect on the alteration of behavior and neurotransmitter levels, their catabolites and metabolites, as well as the interaction between immune responses and this parasite in the etiopathogenesis of psychiatric disorders. The dysfunction of neurotransmitters in the neural transmission is associated with several neuropsychiatric disorders. However, further intensive studies are required to determine the effect of this parasite on altering the level of neurotransmitters and the role of neurotransmitters in the etiology of host behavioral changes.
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Metadaten
Titel
Toxoplasmosis: Targeting neurotransmitter systems in psychiatric disorders
verfasst von
Tooran Nayeri
Shahabeddin Sarvi
Ahmad Daryani
Publikationsdatum
03.09.2021
Verlag
Springer US
Erschienen in
Metabolic Brain Disease / Ausgabe 1/2022
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI
https://doi.org/10.1007/s11011-021-00824-2

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