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Erschienen in:
01.07.2007 | Original Paper
Pattern of recurrence in paediatric malignant glioma: an institutional experience
Erschienen in: Journal of Neuro-Oncology | Ausgabe 3/2007
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Background:
The purpose of this retrospective study was to investigate the pattern of recurrence in paediatric malignant gliomas.
Material and methods: We reviewed the notes, diagnostic imaging and treatment charts of 30 consecutive paediatric patients (age less than 18 years at diagnosis, range 0.5–17 years) presenting with a malignant glioma presenting to the paediatric oncology unit at the Royal Marsden Hospital over a 10-year period. The imaging at the time of first relapse was compared with the initial diagnostic scans to define a relapse as local, marginal or distant.
Results:
Median follow-up was 13 months (range 1–99 months). Twenty-four of 30 patients (80%) showed evidence of progression with a median time to progression of 8.5 months (range 3–64 months). Thirteen out of 24 patients developed local or marginal recurrences while 11/24 patients recurred at distant sites as site of first relapse (46%).
Conclusion:
Our series suggests that the pattern of relapses in paediatric malignant gliomas could be different from that reported in adult studies as we observed a significant incidence of distant relapses. Larger prospective series need to be conducted to investigate the clinico-biological characteristics of the population at high risk for leptomeningeal dissemination.