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Journal of Neuro-Oncology

Erschienen in:

01.07.2015 | Editors' Invited Manuscript

Current challenges in designing GBM trials for immunotherapy

verfasst von: Shiao-Pei Weathers, Mark R. Gilbert

Erschienen in: Journal of Neuro-Oncology | Ausgabe 3/2015

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Abstract

Immune system modulation is evolving into a promising treatment modality in glioblastoma. Our growing understanding of glioma immunobiology has fueled efforts to develop immunotherapeutic strategies to combat this lethal primary brain tumor. Autologous stimulated lymphocytes, immunotherapy with cytokines and dendritic cells, immune checkpoint inhibitors, virotherapy, and tumor or peptide based vaccines are immunotherapy approaches under active investigation. A number of challenges are evident in the design of immunotherapy clinical trials in glioblastoma including patient selection, immune and imaging response monitoring, and evaluation of clinical outcome.

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Titel: Current challenges in designing GBM trials for immunotherapy
verfasst von: Shiao-Pei Weathers
Mark R. Gilbert
Publikationsdatum: 01.07.2015
Verlag: Springer US
Erschienen in: Journal of Neuro-Oncology / Ausgabe 3/2015
Print ISSN: 0167-594X
Elektronische ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-015-1716-2

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