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Journal of Neuro-Oncology

Erschienen in:

28.06.2019 | Clinical Study

Primary central nervous system tumor treatment and survival in the United States, 2004–2015

verfasst von: Catherine R. Garcia, Stacey A. Slone, Therese A. Dolecek, Bin Huang, Janna H. Neltner, John L. Villano

Erschienen in: Journal of Neuro-Oncology | Ausgabe 1/2019

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Abstract

Introduction

Brain tumor treatment and survival information is generally limited in large-scale cancer datasets. We provide a clinical investigation of current patterns of care and survival estimates for central nervous system (CNS) tumors treated in the United States.

Methods

We analyzed the National Cancer Database from 2004–2015 for all patients with diagnosis of primary CNS tumors. We describe patient demographics, treatment modality, and analyzed survival estimates.

Results

512,168 patient tumor records were examined. The most common histology was meningioma (43.6%), followed by glioblastoma (22.0%), and nerve sheath tumors (10.6%). Patients had a median age of 60 years, with a female (57.9%), white (85.0%), and non-Hispanic (87.8%) predominance. Tumors were reported as World Health Organization (WHO) grade I for 55.9% of the patients, grade II for 5.9%, grade III for 4.4%, grade IV for 24.3%, and grade unknown or not applicable for 9.4%. Overall, 56% underwent surgical procedures, 30.4% received radiation, and 20.6% received chemotherapy. Radiation plus chemotherapy and surgery was the most common treatment modality in high-grade tumors (40.5% in WHO grade III and 49.3% in WHO grade IV), while surgery only or watchful waiting was preferred in low-grade tumors. Older age, male gender, non-Hispanic origin, higher number of comorbidities, and lower socioeconomic status were identified as risk factors for mortality.

Conclusions

Our analysis provides long-term survival estimates and initial treatment decisions for patients with CNS tumors in hospitals throughout the United States. Age, comorbidities, gender, ethnicity, and socioeconomic characteristics were determinants of survival.

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Titel: Primary central nervous system tumor treatment and survival in the United States, 2004–2015
verfasst von: Catherine R. Garcia
Stacey A. Slone
Therese A. Dolecek
Bin Huang
Janna H. Neltner
John L. Villano
Publikationsdatum: 28.06.2019
Verlag: Springer US
Erschienen in: Journal of Neuro-Oncology / Ausgabe 1/2019
Print ISSN: 0167-594X
Elektronische ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-019-03218-8

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