Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Typ-2-Diabetes und Adipositas Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Häufige urologisch-sexualmedizinische Themen in der Praxis sind das Thema des MMW-Webinars am 5. Juni von 17.30 bis 19 Uhr. Konkret geht es um die Frage, wann bei Harnwegsinfektionen auf Antibiotika verzichtet werden kann, und um ein Update zur Therapie von Libido- und Potenzstörungen des Mannes. Der dritte Vortrag behandelt sexuell übertragbare Krankheiten. Stellen Sie Ihre Fragen an die Experten und sammeln Sie 2 CME-Punkte. Jetzt gleich anmelden!
Erweiterte Suche
Anmelden
nach oben
Current Neurology and Neuroscience Reports
Erschienen in: Current Neurology and Neuroscience Reports 1/2015

01.01.2015 | Stroke (HP Adams, Section Editor)

Sleep Apnea and Stroke

verfasst von: Antonio Culebras

Erschienen in: Current Neurology and Neuroscience Reports | Ausgabe 1/2015

Einloggen, um Zugang zu erhalten

Abstract

Clinical evidence has established that sleep apnea is a risk factor for stroke. Patients with stroke have a high prevalence of sleep apnea that may have preceded or developed as a result of the stroke. Well-established concurrent stroke risk factors for stroke like hypertension and atrial fibrillation respond favorably to the successful treatment of sleep apnea. The gold standard diagnosis of sleep apnea is obtained in the sleep laboratory, but unattended polysomnography is gaining acceptance. Positive airway pressure (PAP) (continuous positive airway pressure [CPAP] or bilevel positive airway pressure [BiPAP]) applications are the gold-standard treatment of sleep apnea. Suggestive evidence indicates that stroke occurrence or recurrence may be reduced with treatment of sleep apnea.
Literatur
1.
Yaggi HK, Concato J, Kernan WN, et al. Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med. 2005;353:2034.PubMedCrossRef
2.
Muñoz R, Durán-Cantolla J, Martínez-Vila E, Gallego J, Rubio R, Aizpuru F, et al. Severe sleep apnea and risk of ischemic stroke in the elderly. Stroke. 2006;37:2317–21.PubMedCrossRef
3.
Arzt M, Young T, Finn L, et al. Association of sleep-disordered breathing and the occurrence of stroke. Am J Respir Crit Care Med. 2005;172:1447.PubMedCentralPubMedCrossRef
4.•
Redline S, Yenokyan G, Gottlieb DJ, Shahar E, O’Connor GT, Resnick HE, et al. Obstructive sleep apnea-hypopnea and incident stroke: the sleep heart health study. Am J Respir Crit Care Med. 2010;182:269–77. Provides objective evidence that sleep apnea is a risk factor for stroke.PubMedCentralPubMedCrossRef
5.•
Chang CC, Chuang HC, Lin CL, et al. High incidence of stroke in young women with sleep apnea syndrome. Sleep Med. 2014;15:410. Provides objective evidence that sleep apnea is a risk factor for stroke in young women.PubMedCrossRef
6.•
Culebras A. Sleep apnea and stroke in young women: the many faces of the disorder. Sleep Med. 2014;15:377. Supports editorially that sleep apnea is a risk factor for stroke in young women.PubMedCrossRef
7.•
Alexandrov AV, Nguyen HT, Rubiera M, et al. Prevalence and risk factors associated with reversed Robin Hood syndrome in acute ischemic stroke. Stroke. 2009;40:2738–42. Alerts to the fact and explains why sleep apnea can lead to acute stroke deterioration.PubMedCrossRef
8.•
Yaffe K, Laffan AM, Harrison SL, Redline S, Spira AP, Ensrud KE, et al. Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women. JAMA. 2011;306:613–9. Provides evidence that cognitive impairment may be an outcome of sleep apnea.PubMedCentralPubMed
9.
Román GC. Pathogenesis of cerebral small-vessel disease in obstructive sleep apnea. In: Culebras A, editor. Sleep, stroke and cardiovascular disease. Cambridge University Press, 2013, p. 97.
10.
Kim H, Yun CH, Thomas RJ, Lee SH, Seo HS, Cho ER, et al. Obstructive sleep apnea as a risk factor for cerebral white matter change in a middle-aged and older general population. Sleep. 2013;36(5):709–715B.PubMedCentralPubMed
11.
Cho ER, Kim H, Seo HS, Suh S, Lee SK, Shin C. Obstructive sleep apnea as a risk factor for silent cerebral infarction. J Sleep Res. 2013;22(4):452–8.PubMedCrossRef
12.
Román GC, Erkinjuntti T, Wallin A, Pantoni L, Chui HC. Subcortical ischaemic vascular dementia. Lancet Neurol. 2002;1(7):426–36.PubMedCrossRef
13.
Nieto FJ, Young TB, Lind BK, Shahar E, Samet JM, Redline S, et al. Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. Sleep Heart Health Study. JAMA. 2000;283(14):1829–36.PubMedCrossRef
14.
Peppard PE, Young T, Palta M, Skatrud J. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med. 2000;342(19):1378–84.PubMedCrossRef
15.
Logan AG, Perlikowski SM, Mente A, Tisler A, Tkacova R, Niroumand M, et al. High prevalence of unrecognized sleep apnoea in drug-resistant hypertension. J Hypertens. 2001;19(12):2271–7.PubMedCrossRef
16.
Dernaika TA, Kinasewitz GT, Tawk MM. Effects of nocturnal continuous positive airway pressure therapy in patients with resistant hypertension and obstructive sleep apnea. J Clin Sleep Med. 2009;5(2):103–7.PubMedCentralPubMed
17.
Horne RS, Yang JS, Walter LM, Richardson HL, O’Driscoll DM, Foster AM, et al. Elevated blood pressure during sleep and wake in children with sleep-disordered breathing. Pediatrics. 2011;128(1):e85–92.PubMedCrossRef
18.
Hla KM, Young T, Finn L, Peppard PE, Szklo-Coxe M, Stubbs M. Longitudinal association of sleep-disordered breathing and nondipping of nocturnal blood pressure in the Wisconsin Sleep Cohort Study. Sleep. 2008;31(6):795–800.PubMedCentralPubMed
19.
20.
Cortelli P. Sleep apnea, autonomic dysfunction, and vascular disease. In: Culebras A, editor. Sleep, stroke, and cardiovascular disease. Cambridge University Press; 2013. p. 33.
21.
Noda A, Nakata S, Koike Y, et al. Continuous positive airway pressure improves daytime baroreflex sensitivity and nitric oxide production in patients with moderate to severe obstructive sleep apnea syndrome. Hypertens Res. 2007;30:669–76.PubMedCrossRef
22.
Thomas RJ. Arousals in sleep-disordered breathing: patterns and implications. Sleep. 2003;26:1042–7.PubMed
23.
Narkiewicz K, Somers VK. The sympathetic nervous system and obstructive sleep apnea: implications for hypertension. J Hypertens. 1997;15:1613–9.PubMedCrossRef
24.•
Berger S, Lavie L. Sleep apnea, oxidative stress, pro-inflammatory vascular risk factors and endothelial disease. In: Culebras A, editor. Sleep, stroke, and cardiovascular disease. Cambridge University Press, 2013, p. 11. Provides evidence that pro-inflammatory risk factors intervene in raising the risk of stroke in sleep apnea patients.
25.
Champagne K, Schwartzman K, Opatrny L, Barriga P, Morin L, Mallozzi A, et al. Obstructive sleep apnoea and its association with gestational hypertension. Eur Respir J. 2009;33(3):559–65.PubMedCrossRef
26.•
Bourjeily G, Ankner G, Mohsenin V. Sleep-disordered breathing in pregnancy. Clin Chest Med. 2011;32(1):175–89. Provides evidence that sleep apnea is deleterious during pregnancy and may lead to preeclampsia.PubMedCrossRef
27.
Gami AS. Sleep apnea and atrial fibrillation. In: Culebras A, editor. Sleep, stroke, and cardiovascular disease. Cambridge University Press; 2013. p. 80.
28.
Sauer WH, McKernan ML, Lin D, Gerstenfeld EP, Callans DJ, Marchlinski FE. Clinical predictors and outcomes associated with acute return of pulmonary vein conduction during pulmonary vein isolation for treatment of atrial fibrillation. Heart Rhythm. 2006;3(9):1024–8.PubMedCrossRef
29.
Patel D, Mohanty P, Di Biase L, Shaheen M, Lewis WR, Quan K, et al. Safety and efficacy of pulmonary vein antral isolation in patients with obstructive sleep apnea: the impact of continuous positive airway pressure. Circ Arrhythm Electrophysiol. 2010;3(5):445–51.PubMedCrossRef
30.
Lynch JJ et al. Prevalence of right-to-left atrial shunting in a healthy population: detection by Valsalva maneuver contrast echocardiography. Am J Cardiol. 1984;53:1478–806.PubMedCrossRef
31.
Beelke M, Angeli S, Del Sette M, Gandolfo C, Cabano ME, Canovaro P, et al. Prevalence of patent foramen ovale in subjects with obstructive sleep apnea: a transcranial Doppler ultrasound study. Sleep Med. 2003;4(3):219–23.PubMedCrossRef
32.
Sanner BM, Doberauer C, Konermann M, Sturm A, Zidek W. Pulmonary hypertension in patients with obstructive sleep apnea syndrome. Arch Intern Med. 1997;157(21):2483–7.PubMedCrossRef
33.
Ciccone A, Proserpio P, Roccatagliata DV, Nichelatti M, Gigli GL, Parati G, et al. Wake-up stroke and TIA due to paradoxical embolism during long obstructive sleep apnoeas: a cross-sectional study. Thorax. 2013;68(1):97–104.PubMedCrossRef
34.
Netzer NC. Impaired nocturnal cerebral hemodynamics during long obstructive apneas: the key to understanding stroke in OSAS patients? Sleep. 2010;33(2):146–7.PubMedCentralPubMed
35.
Jiménez PE, Coloma R, Segura T. Brain haemodynamics in obstructive sleep apnea syndrome. Rev Neurol. 2005;41 Suppl 3:S21–4.PubMed
36.
Pizza F, Biallas M, Wolf M, Werth E, Bassetti CL. Nocturnal cerebral hemodynamics in snorers and in patients with obstructive sleep apnea: a near-infrared spectroscopy study. Sleep. 2010;33:205–10.PubMedCentralPubMed
37.
Neau JP, Paquereau J, Meurice JC, et al. Auditory event-related potentials before and after treatment with nasal continuous positive airway pressure in sleep apnea syndrome. Eur J Neurol. 1996;3:29–35.CrossRef
38.
Hogan AM, Hill CM, Harrison D, Kirkham FJ. Cerebral blood flow velocity and cognition in children before and after adenotonsillectomy. Pediatrics. 2008;122:75–82.PubMedCrossRef
39.••
International classification of sleep disorders, 3rd ed, American Academy of Sleep Medicine, Darien, IL 2014.**[Reference book for all interested in sleep disorders]
40.••
Kernan WN, Ovbiagele B, Black HR, et al. Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014;45:2160. Reference text for all interested in stroke.PubMedCrossRef
41.
Epstein LJ, Kristo D, Strollo Jr PJ, et al. Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med. 2009;5:263.PubMed
42.
Lozano L, Tovar JL, Sampol G, Romero O, Jurado MJ, et al. Continuous positive airway pressure treatment in sleep apnea patients with resistant hypertension: a randomized, controlled trial. J Hypertens. 2010;28:2161–8.PubMedCrossRef
43.
Kanagala R, Murali NS, Friedman PA, Ammash NM, Gersh BJ, Ballman KV, et al. Obstructive sleep apnea and the recurrence of atrial fibrillation. Circulation. 2003;107:2589–94.PubMed
44.
45.
46.
Parra O, Arboix A, Bechich S, et al. Time course of sleep-related breathing disorders in first-ever stroke or transient ischemic attack. Am J Respir Crit Care Med. 2000;161:375.PubMedCrossRef
47.
Sandberg O, Franklin KA, Bucht G, Gustafson Y. Sleep apnea, delirium, depressed mood, cognition, and ADL ability after stroke. J Am Geriatr Soc. 2001;49(4):391–7.PubMedCrossRef
48.
Kaneko Y, Hajek VE, Zivanovic V, Raboud J, Bradley TD. Relationship of sleep apnea to functional capacity and length of hospitalization following stroke. Sleep. 2003;26(3):293–7.PubMed
49.
Cherkassky T, Oksenberg A, Froom P, Ring H. Sleep-related breathing disorders and rehabilitation outcome of stroke patients: a prospective study. Am J Phys Med Rehabil. 2003;82(6):452–5.PubMed
50.
Bravata DM, Concato J, Fried T, Ranjbar N, Sadarangani T, McClain V, et al. Auto-titrating continuous positive airway pressure for patients with acute transient ischemic attack: a randomized feasibility trial. Stroke. 2010;41:1464–70.PubMedCrossRef
51.
Martínez-García MA, Soler-Cataluña JJ, Ejarque-Martínez L, et al. Continuous positive airway pressure treatment reduces mortality in patients with ischemic stroke and obstructive sleep apnea: a 5-year follow-up study. Am J Respir Crit Care Med. 2009;180:36.PubMedCrossRef
52.•
Martínez-García MA, Campos-Rodríguez F, Soler-Cataluña JJ, et al. Increased incidence of nonfatal cardiovascular events in stroke patients with sleep apnoea: effect of CPAP treatment. Eur Respir J. 2012;39:906. Increases awareness of the importance of sleep apnea treatment in stroke.PubMedCrossRef
Metadaten
Titel
Sleep Apnea and Stroke
verfasst von
Antonio Culebras
Publikationsdatum
01.01.2015
Verlag
Springer US
Erschienen in
Current Neurology and Neuroscience Reports / Ausgabe 1/2015
Print ISSN: 1528-4042
Elektronische ISSN: 1534-6293
DOI
https://doi.org/10.1007/s11910-014-0503-3

Weitere Artikel der Ausgabe 1/2015

Current Neurology and Neuroscience Reports 1/2015 Zur Ausgabe

Movement Disorders (M Okun, Section Editor)

An Update and Review of the Treatment of Myoclonus

Movement Disorders (M Okun, Section Editor)

An Update on the Use of Botulinum Toxin Therapy in Parkinson’s Disease

Sleep (M Thorpy, M Billiard, Section Editors)

Cataplexy and Sleep Disorders in Niemann-Pick Type C Disease

Stroke (HP Adams, Section Editor)

Nanotheragnostic Applications for Ischemic and Hemorrhagic Strokes: Improved Delivery for a Better Prognosis

Neuro-Oncology (LE Abrey, Section Editor)

Treatment Considerations for MGMT-Unmethylated Glioblastoma

Neuro-Oncology (LE Abrey, Section Editor)

Vaccine Therapies in Malignant Glioma

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Sozialer Aufstieg verringert Demenzgefahr

24.05.2024 Demenz Nachrichten

Ein hohes soziales Niveau ist mit die beste Versicherung gegen eine Demenz. Noch geringer ist das Demenzrisiko für Menschen, die sozial aufsteigen: Sie gewinnen fast zwei demenzfreie Lebensjahre. Umgekehrt steigt die Demenzgefahr beim sozialen Abstieg.

Hirnblutung unter DOAK und VKA ähnlich bedrohlich

17.05.2024 Direkte orale Antikoagulanzien Nachrichten

Kommt es zu einer nichttraumatischen Hirnblutung, spielt es keine große Rolle, ob die Betroffenen zuvor direkt wirksame orale Antikoagulanzien oder Marcumar bekommen haben: Die Prognose ist ähnlich schlecht.

Was nützt die Kraniektomie bei schwerer tiefer Hirnblutung?

17.05.2024 Hirnblutung Nachrichten

Eine Studie zum Nutzen der druckentlastenden Kraniektomie nach schwerer tiefer supratentorieller Hirnblutung deutet einen Nutzen der Operation an. Für überlebende Patienten ist das dennoch nur eine bedingt gute Nachricht.

Thrombektomie auch bei großen Infarkten von Vorteil

16.05.2024 Ischämischer Schlaganfall Nachrichten

Auch ein sehr ausgedehnter ischämischer Schlaganfall scheint an sich kein Grund zu sein, von einer mechanischen Thrombektomie abzusehen. Dafür spricht die LASTE-Studie, an der Patienten und Patientinnen mit einem ASPECTS von maximal 5 beteiligt waren.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise