Skip to main content
Erschienen in: Current Treatment Options in Neurology 11/2019

01.11.2019 | Pediatric Neurology (A Yeshokumar, Section Editor)

Transcranial Magnetic Stimulation for the Treatment of Pediatric Neurological Disorders

verfasst von: Laura A. Malone, MD, PhD, Lisa R. Sun, MD

Erschienen in: Current Treatment Options in Neurology | Ausgabe 11/2019

Einloggen, um Zugang zu erhalten

Abstract

Purpose of review

Repetitive transcranial magnetic stimulation (rTMS) is a form of noninvasive brain stimulation that is used for the treatment of migraine and major depression in adults and is now being evaluated for use in other disorders. The purpose of this review is to summarize the physiology underlying TMS, the safety and tolerability in pediatric patients, and the evidence for TMS efficacy in the treatment of pediatric neurologic disorders.

Recent findings

Studies investigating rTMS for adolescent depression, hemiparesis due to pediatric stroke, autism, and tics/Tourette syndrome have demonstrated some therapeutic benefit. rTMS has been insufficiently studied for migraine in children despite benefits demonstrated for adult migraine. Evidence for rTMS in childhood epilepsy and ADHD remains mixed.

Summary

Repetitive transcranial magnetic stimulation is emerging as a safe, tolerable, and potentially effective therapeutic strategy in a number of pediatric neurological disorders, though high-quality, randomized controlled trials are needed. Ongoing studies should focus on optimization of treatment protocols, development of biomarkers to identify children who will benefit from the technique, and identification of the most appropriate indicators of response.
Literatur
1.
Zurück zum Zitat Barker AT, Jalinous R, Freeston IL. Non-invasive magnetic stimulation of human motor cortex. Lancet. 1985;1:1106–7.PubMedCrossRef Barker AT, Jalinous R, Freeston IL. Non-invasive magnetic stimulation of human motor cortex. Lancet. 1985;1:1106–7.PubMedCrossRef
2.
Zurück zum Zitat Eldaief MC, Press DZ, Pascual-Leone A. Transcranial magnetic stimulation in neurology: a review of established and prospective applications. Neurol Clin Pract. 2013;3:519–26.PubMedPubMedCentralCrossRef Eldaief MC, Press DZ, Pascual-Leone A. Transcranial magnetic stimulation in neurology: a review of established and prospective applications. Neurol Clin Pract. 2013;3:519–26.PubMedPubMedCentralCrossRef
3.
Zurück zum Zitat Schwedt TJ, Vargas B. Neurostimulation for treatment of migraine and cluster headache. Pain Med. 2015;16:1827–34.PubMedCrossRef Schwedt TJ, Vargas B. Neurostimulation for treatment of migraine and cluster headache. Pain Med. 2015;16:1827–34.PubMedCrossRef
4.
Zurück zum Zitat Hameed MQ, Dhamne SC, Gersner R, Kaye HL, Oberman LM, Pascual-Leone A, et al. Transcranial magnetic and direct current stimulation in children. Curr Neurol Neurosci Rep. 2017;17:11.PubMedPubMedCentralCrossRef Hameed MQ, Dhamne SC, Gersner R, Kaye HL, Oberman LM, Pascual-Leone A, et al. Transcranial magnetic and direct current stimulation in children. Curr Neurol Neurosci Rep. 2017;17:11.PubMedPubMedCentralCrossRef
5.
Zurück zum Zitat Kobayashi M, Pascual-Leone A. Transcranial magnetic stimulation in neurology. Lancet Neurol. 2003;2:145–56.PubMedCrossRef Kobayashi M, Pascual-Leone A. Transcranial magnetic stimulation in neurology. Lancet Neurol. 2003;2:145–56.PubMedCrossRef
6.
Zurück zum Zitat Narayana S, Papanicolaou AC, McGregor A, Boop FA, Wheless JW. Clinical applications of transcranial magnetic stimulation in pediatric neurology. J Child Neurol. 2015;30:1111–24.PubMedCrossRef Narayana S, Papanicolaou AC, McGregor A, Boop FA, Wheless JW. Clinical applications of transcranial magnetic stimulation in pediatric neurology. J Child Neurol. 2015;30:1111–24.PubMedCrossRef
7.
Zurück zum Zitat Allen CH, Kluger BM, Buard I. Safety of transcranial magnetic stimulation in children: a systematic review of the literature. Pediatr Neurol. 2017;68:3–17.PubMedPubMedCentralCrossRef Allen CH, Kluger BM, Buard I. Safety of transcranial magnetic stimulation in children: a systematic review of the literature. Pediatr Neurol. 2017;68:3–17.PubMedPubMedCentralCrossRef
8.
Zurück zum Zitat Huang Y-Z, Edwards MJ, Rounis E, Bhatia KP, Rothwell JC. Theta burst stimulation of the human motor cortex. Neuron. 2005;45:201–6.PubMedCrossRef Huang Y-Z, Edwards MJ, Rounis E, Bhatia KP, Rothwell JC. Theta burst stimulation of the human motor cortex. Neuron. 2005;45:201–6.PubMedCrossRef
9.
Zurück zum Zitat Eyre JA, Taylor JP, Villagra F, Smith M, Miller S. Evidence of activity-dependent withdrawal of corticospinal projections during human development. Neurology. 2001;57:1543–54.PubMedCrossRef Eyre JA, Taylor JP, Villagra F, Smith M, Miller S. Evidence of activity-dependent withdrawal of corticospinal projections during human development. Neurology. 2001;57:1543–54.PubMedCrossRef
10.
Zurück zum Zitat Eyre JA, Smith M, Dabydeen L, Clowry GJ, Petacchi E, Battini R, et al. Is hemiplegic cerebral palsy equivalent to amblyopia of the corticospinal system? Ann Neurol. 2007;62:493–503.PubMedCrossRef Eyre JA, Smith M, Dabydeen L, Clowry GJ, Petacchi E, Battini R, et al. Is hemiplegic cerebral palsy equivalent to amblyopia of the corticospinal system? Ann Neurol. 2007;62:493–503.PubMedCrossRef
11.
Zurück zum Zitat Sun W, Mao W, Meng X, Wang D, Qiao L, Tao W, et al. Low-frequency repetitive transcranial magnetic stimulation for the treatment of refractory partial epilepsy: a controlled clinical study. Epilepsia. 2012;53:1782–9.PubMedCrossRef Sun W, Mao W, Meng X, Wang D, Qiao L, Tao W, et al. Low-frequency repetitive transcranial magnetic stimulation for the treatment of refractory partial epilepsy: a controlled clinical study. Epilepsia. 2012;53:1782–9.PubMedCrossRef
12.
Zurück zum Zitat Garvey MA, Kaczynski KJ, Becker DA, Bartko JJ. Subjective reactions of children to single-pulse transcranial magnetic stimulation. J Child Neurol. 2001;16:891–4.PubMedCrossRef Garvey MA, Kaczynski KJ, Becker DA, Bartko JJ. Subjective reactions of children to single-pulse transcranial magnetic stimulation. J Child Neurol. 2001;16:891–4.PubMedCrossRef
13.
Zurück zum Zitat Gaynes BN, Lloyd SW, Lux L, Gartlehner G, Hansen RA, Brode S, et al. Repetitive transcranial magnetic stimulation for treatment-resistant depression: a systematic review and meta-analysis. J Clin Psychiatry. 2014;75:477–89 quiz 489.PubMedCrossRef Gaynes BN, Lloyd SW, Lux L, Gartlehner G, Hansen RA, Brode S, et al. Repetitive transcranial magnetic stimulation for treatment-resistant depression: a systematic review and meta-analysis. J Clin Psychiatry. 2014;75:477–89 quiz 489.PubMedCrossRef
14.
Zurück zum Zitat Horvath JC, Mathews J, Demitrack MA, Pascual-Leone A. The NeuroStar TMS device: conducting the FDA approved protocol for treatment of depression. J Vis Exp. 2010. Horvath JC, Mathews J, Demitrack MA, Pascual-Leone A. The NeuroStar TMS device: conducting the FDA approved protocol for treatment of depression. J Vis Exp. 2010.
15.
Zurück zum Zitat Koenigs M, Grafman J. The functional neuroanatomy of depression: distinct roles for ventromedial and dorsolateral prefrontal cortex. Behav Brain Res. 2009;201:239–43.PubMedPubMedCentralCrossRef Koenigs M, Grafman J. The functional neuroanatomy of depression: distinct roles for ventromedial and dorsolateral prefrontal cortex. Behav Brain Res. 2009;201:239–43.PubMedPubMedCentralCrossRef
16.
Zurück zum Zitat Yang X-R, Kirton A, Wilkes TC, Pradhan S, Liu I, Jaworska N, et al. Glutamate alterations associated with transcranial magnetic stimulation in youth depression: a case series. J ECT. 2014;30:242–7.PubMedCrossRef Yang X-R, Kirton A, Wilkes TC, Pradhan S, Liu I, Jaworska N, et al. Glutamate alterations associated with transcranial magnetic stimulation in youth depression: a case series. J ECT. 2014;30:242–7.PubMedCrossRef
17.
Zurück zum Zitat Wall CA, Croarkin PE, Sim LA, Husain MM, Janicak PG, Kozel FA, et al. Adjunctive use of repetitive transcranial magnetic stimulation in depressed adolescents: a prospective, open pilot study. J Clin Psychiatry. 2011;72:1263–9.PubMedCrossRef Wall CA, Croarkin PE, Sim LA, Husain MM, Janicak PG, Kozel FA, et al. Adjunctive use of repetitive transcranial magnetic stimulation in depressed adolescents: a prospective, open pilot study. J Clin Psychiatry. 2011;72:1263–9.PubMedCrossRef
18.
Zurück zum Zitat •• MacMaster FP, Croarkin PE, Wilkes TC, McLellan Q, Langevin LM, Jaworska N, et al. Repetitive transcranial magnetic stimulation in youth with treatment resistant major depression. Front Psychiatry. 2019;10:170. In this study of 32 adolescents and young adults (ages 13–21) with treatment-resistant major depressive disorder, rTMS over the left DLPFC for 15 consecutive weekdays resulted in clinically significant improvement in symptom severity in 56% of subjects. PubMedPubMedCentralCrossRef •• MacMaster FP, Croarkin PE, Wilkes TC, McLellan Q, Langevin LM, Jaworska N, et al. Repetitive transcranial magnetic stimulation in youth with treatment resistant major depression. Front Psychiatry. 2019;10:170. In this study of 32 adolescents and young adults (ages 13–21) with treatment-resistant major depressive disorder, rTMS over the left DLPFC for 15 consecutive weekdays resulted in clinically significant improvement in symptom severity in 56% of subjects. PubMedPubMedCentralCrossRef
19.
Zurück zum Zitat Donaldson AE, Gordon MS, Melvin GA, Barton DA, Fitzgerald PB. Addressing the needs of adolescents with treatment resistant depressive disorders: a systematic review of rTMS. Brain Stimul. 2014;7:7–12.PubMedCrossRef Donaldson AE, Gordon MS, Melvin GA, Barton DA, Fitzgerald PB. Addressing the needs of adolescents with treatment resistant depressive disorders: a systematic review of rTMS. Brain Stimul. 2014;7:7–12.PubMedCrossRef
20.
Zurück zum Zitat Zhang T, Zhu J, Xu L, Tang X, Cui H, Wei Y, et al. Add-on rTMS for the acute treatment of depressive symptoms is probably more effective in adolescents than in adults: evidence from real-world clinical practice. Brain Stimul. 2019;12:103–9.PubMedCrossRef Zhang T, Zhu J, Xu L, Tang X, Cui H, Wei Y, et al. Add-on rTMS for the acute treatment of depressive symptoms is probably more effective in adolescents than in adults: evidence from real-world clinical practice. Brain Stimul. 2019;12:103–9.PubMedCrossRef
21.
Zurück zum Zitat Mayer G, Aviram S, Walter G, Levkovitz Y, Bloch Y. Long-term follow-up of adolescents with resistant depression treated with repetitive transcranial magnetic stimulation. J ECT. 2012;28:84–6.PubMedCrossRef Mayer G, Aviram S, Walter G, Levkovitz Y, Bloch Y. Long-term follow-up of adolescents with resistant depression treated with repetitive transcranial magnetic stimulation. J ECT. 2012;28:84–6.PubMedCrossRef
22.
Zurück zum Zitat Bloch Y, Grisaru N, Harel EV, Beitler G, Faivel N, Ratzoni G, et al. Repetitive transcranial magnetic stimulation in the treatment of depression in adolescents: an open-label study. J ECT. 2008;24:156–9.PubMedCrossRef Bloch Y, Grisaru N, Harel EV, Beitler G, Faivel N, Ratzoni G, et al. Repetitive transcranial magnetic stimulation in the treatment of depression in adolescents: an open-label study. J ECT. 2008;24:156–9.PubMedCrossRef
23.
Zurück zum Zitat Wall CA, Croarkin PE, McClintock SM, Murphy LL, Bandel LA, Sim LA, et al. Neurocognitive effects of repetitive transcranial magnetic stimulation in adolescents with major depressive disorder. Front Psychiatry. 2013;4:165.PubMedPubMedCentralCrossRef Wall CA, Croarkin PE, McClintock SM, Murphy LL, Bandel LA, Sim LA, et al. Neurocognitive effects of repetitive transcranial magnetic stimulation in adolescents with major depressive disorder. Front Psychiatry. 2013;4:165.PubMedPubMedCentralCrossRef
24.
Zurück zum Zitat Bhola R, Kinsella E, Giffin N, Lipscombe S, Ahmed F, Weatherall M, et al. Single-pulse transcranial magnetic stimulation (sTMS) for the acute treatment of migraine: evaluation of outcome data for the UK post market pilot program. J Headache Pain. 2015;16:535.PubMedCrossRef Bhola R, Kinsella E, Giffin N, Lipscombe S, Ahmed F, Weatherall M, et al. Single-pulse transcranial magnetic stimulation (sTMS) for the acute treatment of migraine: evaluation of outcome data for the UK post market pilot program. J Headache Pain. 2015;16:535.PubMedCrossRef
25.
Zurück zum Zitat Kalita J, Laskar S, Bhoi SK, Misra UK. Efficacy of single versus three sessions of high rate repetitive transcranial magnetic stimulation in chronic migraine and tension-type headache. J Neurol. 2016;263:2238–46.PubMedCrossRef Kalita J, Laskar S, Bhoi SK, Misra UK. Efficacy of single versus three sessions of high rate repetitive transcranial magnetic stimulation in chronic migraine and tension-type headache. J Neurol. 2016;263:2238–46.PubMedCrossRef
26.
Zurück zum Zitat Misra UK, Kalita J, Bhoi SK. High frequency repetitive transcranial magnetic stimulation (rTMS) is effective in migraine prophylaxis: an open labeled study. Neurol Res. 2012;34:547–51.PubMedCrossRef Misra UK, Kalita J, Bhoi SK. High frequency repetitive transcranial magnetic stimulation (rTMS) is effective in migraine prophylaxis: an open labeled study. Neurol Res. 2012;34:547–51.PubMedCrossRef
27.
Zurück zum Zitat Shirahige L, Melo L, Nogueira F, Rocha S, Monte-Silva K. Efficacy of noninvasive brain stimulation on pain control in migraine patients: a systematic review and meta-analysis. Headache. 2016;56:1565–96.PubMedCrossRef Shirahige L, Melo L, Nogueira F, Rocha S, Monte-Silva K. Efficacy of noninvasive brain stimulation on pain control in migraine patients: a systematic review and meta-analysis. Headache. 2016;56:1565–96.PubMedCrossRef
28.
Zurück zum Zitat Lan L, Zhang X, Li X, Rong X, Peng Y. The efficacy of transcranial magnetic stimulation on migraine: a meta-analysis of randomized controlled trails. J Headache Pain. 2017;18:86.PubMedPubMedCentralCrossRef Lan L, Zhang X, Li X, Rong X, Peng Y. The efficacy of transcranial magnetic stimulation on migraine: a meta-analysis of randomized controlled trails. J Headache Pain. 2017;18:86.PubMedPubMedCentralCrossRef
29.
Zurück zum Zitat Wang T, Huang L, Xu H, Yan L, Wu Q, Shen F, et al. Seizure induced by repetitive transcranial magnetic stimulation in an adolescent with migraine with aura. Brain Stimul. 2018;11:1380–1.PubMedCrossRef Wang T, Huang L, Xu H, Yan L, Wu Q, Shen F, et al. Seizure induced by repetitive transcranial magnetic stimulation in an adolescent with migraine with aura. Brain Stimul. 2018;11:1380–1.PubMedCrossRef
30.
Zurück zum Zitat Stinear C, Ackerley S, Byblow W. Rehabilitation is initiated early after stroke, but most motor rehabilitation trials are not: a systematic review. Stroke. 2013;44:2039–45.PubMedCrossRef Stinear C, Ackerley S, Byblow W. Rehabilitation is initiated early after stroke, but most motor rehabilitation trials are not: a systematic review. Stroke. 2013;44:2039–45.PubMedCrossRef
32.
Zurück zum Zitat Murase N, Duque J, Mazzocchio R, Cohen LG. Influence of interhemispheric interactions on motor function in chronic stroke. Ann Neurol. 2004;55:400–9.PubMedCrossRef Murase N, Duque J, Mazzocchio R, Cohen LG. Influence of interhemispheric interactions on motor function in chronic stroke. Ann Neurol. 2004;55:400–9.PubMedCrossRef
33.
Zurück zum Zitat Hoyer EH, Celnik PA. Understanding and enhancing motor recovery after stroke using transcranial magnetic stimulation. Restor Neurol Neurosci. 2011;29:395–409.PubMedPubMedCentral Hoyer EH, Celnik PA. Understanding and enhancing motor recovery after stroke using transcranial magnetic stimulation. Restor Neurol Neurosci. 2011;29:395–409.PubMedPubMedCentral
34.
Zurück zum Zitat Boddington LJ, Reynolds JNJ. Targeting interhemispheric inhibition with neuromodulation to enhance stroke rehabilitation. Brain Stimul. 2017;10:214–22.PubMedCrossRef Boddington LJ, Reynolds JNJ. Targeting interhemispheric inhibition with neuromodulation to enhance stroke rehabilitation. Brain Stimul. 2017;10:214–22.PubMedCrossRef
35.
Zurück zum Zitat Xu J, Branscheidt M, Schambra H, Steiner L, Widmer M, Diedrichsen J, et al. Rethinking interhemispheric imbalance as a target for stroke neurorehabilitation. Ann Neurol. 2019;85:502–13.PubMedCrossRefPubMedCentral Xu J, Branscheidt M, Schambra H, Steiner L, Widmer M, Diedrichsen J, et al. Rethinking interhemispheric imbalance as a target for stroke neurorehabilitation. Ann Neurol. 2019;85:502–13.PubMedCrossRefPubMedCentral
36.
Zurück zum Zitat Hsu W-Y, Cheng C-H, Liao K-K, Lee I-H, Lin Y-Y. Effects of repetitive transcranial magnetic stimulation on motor functions in patients with stroke: a meta-analysis. Stroke. 2012;43:1849–57.PubMedCrossRef Hsu W-Y, Cheng C-H, Liao K-K, Lee I-H, Lin Y-Y. Effects of repetitive transcranial magnetic stimulation on motor functions in patients with stroke: a meta-analysis. Stroke. 2012;43:1849–57.PubMedCrossRef
37.
Zurück zum Zitat Kirton A, Chen R, Friefeld S, Gunraj C, Pontigon A-M, Deveber G. Contralesional repetitive transcranial magnetic stimulation for chronic hemiparesis in subcortical paediatric stroke: a randomised trial. Lancet Neurol. 2008;7:507–13.PubMedCrossRef Kirton A, Chen R, Friefeld S, Gunraj C, Pontigon A-M, Deveber G. Contralesional repetitive transcranial magnetic stimulation for chronic hemiparesis in subcortical paediatric stroke: a randomised trial. Lancet Neurol. 2008;7:507–13.PubMedCrossRef
38.
Zurück zum Zitat Gillick BT, Krach LE, Feyma T, Rich TL, Moberg K, Thomas W, et al. Primed low-frequency repetitive transcranial magnetic stimulation and constraint-induced movement therapy in pediatric hemiparesis: a randomized controlled trial. Dev Med Child Neurol. 2014;56:44–52.PubMedCrossRef Gillick BT, Krach LE, Feyma T, Rich TL, Moberg K, Thomas W, et al. Primed low-frequency repetitive transcranial magnetic stimulation and constraint-induced movement therapy in pediatric hemiparesis: a randomized controlled trial. Dev Med Child Neurol. 2014;56:44–52.PubMedCrossRef
39.
Zurück zum Zitat Eliasson A-C, Bonnier B, Krumlinde-Sundholm L. Clinical experience of constraint induced movement therapy in adolescents with hemiplegic cerebral palsy--a day camp model. Dev Med Child Neurol. 2003;45:357–9.PubMedCrossRef Eliasson A-C, Bonnier B, Krumlinde-Sundholm L. Clinical experience of constraint induced movement therapy in adolescents with hemiplegic cerebral palsy--a day camp model. Dev Med Child Neurol. 2003;45:357–9.PubMedCrossRef
40.
Zurück zum Zitat •• Kirton A, Andersen J, Herrero M, Nettel-Aguirre A, Carsolio L, Damji O, et al. Brain stimulation and constraint for perinatal stroke hemiparesis: the PLASTIC CHAMPS Trial. Neurology. 2016;86:1659–67. The PLASTIC CHAMPS trial randomized 45 children and adolescents ages 6–19 years with hemiparetic cerebral palsy as a result of a perinatal stroke to intensive motor therapy (80 h of therapy over 2 weeks) alone or in combination with low-frequency (inhibitory) rTMS of the contralesional primary motor cortex, constraint-induced movement therapy (CIMT), or both. Addition of rTMS or CIMT to intensive therapy doubled the chances of clinically significant improvement as measured by the assisting hand assessment, with an additive effect when both treatment modalities were used together. Sustained functional gains were demonstrated after 6 months; however, they did gradually decrease over time.PubMedPubMedCentralCrossRef •• Kirton A, Andersen J, Herrero M, Nettel-Aguirre A, Carsolio L, Damji O, et al. Brain stimulation and constraint for perinatal stroke hemiparesis: the PLASTIC CHAMPS Trial. Neurology. 2016;86:1659–67. The PLASTIC CHAMPS trial randomized 45 children and adolescents ages 6–19 years with hemiparetic cerebral palsy as a result of a perinatal stroke to intensive motor therapy (80 h of therapy over 2 weeks) alone or in combination with low-frequency (inhibitory) rTMS of the contralesional primary motor cortex, constraint-induced movement therapy (CIMT), or both. Addition of rTMS or CIMT to intensive therapy doubled the chances of clinically significant improvement as measured by the assisting hand assessment, with an additive effect when both treatment modalities were used together. Sustained functional gains were demonstrated after 6 months; however, they did gradually decrease over time.PubMedPubMedCentralCrossRef
41.
Zurück zum Zitat Hsu W-Y, Cheng C-H, Lin M-W, Shih Y-H, Liao K-K, Lin Y-Y. Antiepileptic effects of low frequency repetitive transcranial magnetic stimulation: a meta-analysis. Epilepsy Res. 2011;96:231–40.PubMedCrossRef Hsu W-Y, Cheng C-H, Lin M-W, Shih Y-H, Liao K-K, Lin Y-Y. Antiepileptic effects of low frequency repetitive transcranial magnetic stimulation: a meta-analysis. Epilepsy Res. 2011;96:231–40.PubMedCrossRef
42.
Zurück zum Zitat Rotenberg A, Bae EH, Takeoka M, Tormos JM, Schachter SC, Pascual-Leone A. Repetitive transcranial magnetic stimulation in the treatment of epilepsia partialis continua. Epilepsy Behav. 2009;14:253–7.PubMedCrossRef Rotenberg A, Bae EH, Takeoka M, Tormos JM, Schachter SC, Pascual-Leone A. Repetitive transcranial magnetic stimulation in the treatment of epilepsia partialis continua. Epilepsy Behav. 2009;14:253–7.PubMedCrossRef
43.
Zurück zum Zitat Graff-Guerrero A, Gonzáles-Olvera J, Ruiz-García M, Avila-Ordoñez U, Vaugier V, García-Reyna JC. rTMS reduces focal brain hyperperfusion in two patients with EPC. Acta Neurol Scand. 2004;109:290–6.PubMedCrossRef Graff-Guerrero A, Gonzáles-Olvera J, Ruiz-García M, Avila-Ordoñez U, Vaugier V, García-Reyna JC. rTMS reduces focal brain hyperperfusion in two patients with EPC. Acta Neurol Scand. 2004;109:290–6.PubMedCrossRef
44.
Zurück zum Zitat Rejnö-Habte Selassie G, Pegenius G, Viggedal G, Hallböök T, Thordstein M. Navigated transcranial magnetic stimulation for preoperative cortical mapping of expressive language in children: development of a method. Epilepsy Behav. 2018;87:180–7.PubMedCrossRef Rejnö-Habte Selassie G, Pegenius G, Viggedal G, Hallböök T, Thordstein M. Navigated transcranial magnetic stimulation for preoperative cortical mapping of expressive language in children: development of a method. Epilepsy Behav. 2018;87:180–7.PubMedCrossRef
45.
Zurück zum Zitat Säisänen L, Könönen M, Julkunen P, Määttä S, Vanninen R, Immonen A, et al. Non-invasive preoperative localization of primary motor cortex in epilepsy surgery by navigated transcranial magnetic stimulation. Epilepsy Res. 2010;92:134–44.PubMedCrossRef Säisänen L, Könönen M, Julkunen P, Määttä S, Vanninen R, Immonen A, et al. Non-invasive preoperative localization of primary motor cortex in epilepsy surgery by navigated transcranial magnetic stimulation. Epilepsy Res. 2010;92:134–44.PubMedCrossRef
46.
Zurück zum Zitat Grados M, Huselid R, Duque-Serrano L. Transcranial magnetic stimulation in Tourette syndrome: a historical perspective, its current use and the influence of comorbidities in treatment response. Brain Sci. 2018;8. Grados M, Huselid R, Duque-Serrano L. Transcranial magnetic stimulation in Tourette syndrome: a historical perspective, its current use and the influence of comorbidities in treatment response. Brain Sci. 2018;8.
47.
Zurück zum Zitat Le K, Liu L, Sun M, Hu L, Xiao N. Transcranial magnetic stimulation at 1 hertz improves clinical symptoms in children with Tourette syndrome for at least 6 months. J Clin Neurosci. 2013;20:257–62.PubMedCrossRef Le K, Liu L, Sun M, Hu L, Xiao N. Transcranial magnetic stimulation at 1 hertz improves clinical symptoms in children with Tourette syndrome for at least 6 months. J Clin Neurosci. 2013;20:257–62.PubMedCrossRef
48.
Zurück zum Zitat Orth M, Kirby R, Richardson MP, Snijders AH, Rothwell JC, Trimble MR, et al. Subthreshold rTMS over pre-motor cortex has no effect on tics in patients with Gilles de la Tourette syndrome. Clin Neurophysiol. 2005;116:764–8.PubMedCrossRef Orth M, Kirby R, Richardson MP, Snijders AH, Rothwell JC, Trimble MR, et al. Subthreshold rTMS over pre-motor cortex has no effect on tics in patients with Gilles de la Tourette syndrome. Clin Neurophysiol. 2005;116:764–8.PubMedCrossRef
49.
Zurück zum Zitat Münchau A, Bloem BR, Thilo KV, Trimble MR, Rothwell JC, Robertson MM. Repetitive transcranial magnetic stimulation for Tourette syndrome. Neurology. 2002;59:1789–91.PubMedCrossRef Münchau A, Bloem BR, Thilo KV, Trimble MR, Rothwell JC, Robertson MM. Repetitive transcranial magnetic stimulation for Tourette syndrome. Neurology. 2002;59:1789–91.PubMedCrossRef
50.
Zurück zum Zitat Kwon HJ, Lim WS, Lim MH, Lee SJ, Hyun JK, Chae J-H, et al. 1-Hz low frequency repetitive transcranial magnetic stimulation in children with Tourette’s syndrome. Neurosci Lett. 2011;492:1–4.PubMedCrossRef Kwon HJ, Lim WS, Lim MH, Lee SJ, Hyun JK, Chae J-H, et al. 1-Hz low frequency repetitive transcranial magnetic stimulation in children with Tourette’s syndrome. Neurosci Lett. 2011;492:1–4.PubMedCrossRef
51.
Zurück zum Zitat Bloch Y, Arad S, Levkovitz Y. Deep TMS add-on treatment for intractable Tourette syndrome: a feasibility study. World J Biol Psychiatry. 2016;17:557–61.PubMed Bloch Y, Arad S, Levkovitz Y. Deep TMS add-on treatment for intractable Tourette syndrome: a feasibility study. World J Biol Psychiatry. 2016;17:557–61.PubMed
52.
Zurück zum Zitat Gilbert DL, Isaacs KM, Augusta M, Macneil LK, Mostofsky SH. Motor cortex inhibition: a marker of ADHD behavior and motor development in children. Neurology. 2011;76:615–21.PubMedPubMedCentralCrossRef Gilbert DL, Isaacs KM, Augusta M, Macneil LK, Mostofsky SH. Motor cortex inhibition: a marker of ADHD behavior and motor development in children. Neurology. 2011;76:615–21.PubMedPubMedCentralCrossRef
53.
Zurück zum Zitat Weaver L, Rostain AL, Mace W, Akhtar U, Moss E, O’Reardon JP. Transcranial magnetic stimulation (TMS) in the treatment of attention-deficit/hyperactivity disorder in adolescents and young adults: a pilot study. J ECT. 2012;28:98–103.PubMedCrossRef Weaver L, Rostain AL, Mace W, Akhtar U, Moss E, O’Reardon JP. Transcranial magnetic stimulation (TMS) in the treatment of attention-deficit/hyperactivity disorder in adolescents and young adults: a pilot study. J ECT. 2012;28:98–103.PubMedCrossRef
54.
Zurück zum Zitat Paz Y, Friedwald K, Levkovitz Y, Zangen A, Alyagon U, Nitzan U, et al. Randomised sham-controlled study of high-frequency bilateral deep transcranial magnetic stimulation (dTMS) to treat adult attention hyperactive disorder (ADHD): negative results. World J Biol Psychiatry. 2018;19:561–6.PubMedCrossRef Paz Y, Friedwald K, Levkovitz Y, Zangen A, Alyagon U, Nitzan U, et al. Randomised sham-controlled study of high-frequency bilateral deep transcranial magnetic stimulation (dTMS) to treat adult attention hyperactive disorder (ADHD): negative results. World J Biol Psychiatry. 2018;19:561–6.PubMedCrossRef
55.
Zurück zum Zitat Finisguerra A, Borgatti R, Urgesi C. Non-invasive brain stimulation for the rehabilitation of children and adolescents with neurodevelopmental disorders: a systematic review. Front Psychol. 2019;10:135.PubMedPubMedCentralCrossRef Finisguerra A, Borgatti R, Urgesi C. Non-invasive brain stimulation for the rehabilitation of children and adolescents with neurodevelopmental disorders: a systematic review. Front Psychol. 2019;10:135.PubMedPubMedCentralCrossRef
56.
Zurück zum Zitat Barahona-Corrêa JB, Velosa A, Chainho A, Lopes R, Oliveira-Maia AJ. Repetitive transcranial magnetic stimulation for treatment of autism spectrum disorder: a systematic review and meta-analysis. Front Integr Neurosci. 2018;12:27.PubMedPubMedCentralCrossRef Barahona-Corrêa JB, Velosa A, Chainho A, Lopes R, Oliveira-Maia AJ. Repetitive transcranial magnetic stimulation for treatment of autism spectrum disorder: a systematic review and meta-analysis. Front Integr Neurosci. 2018;12:27.PubMedPubMedCentralCrossRef
57.
Zurück zum Zitat Moussavi Z, Suleiman A, Rutherford G, Ranjbar Pouya O, Dastgheib Z, Zhang W, et al. A pilot randomised double-blind study of the tolerability and efficacy of repetitive transcranial magnetic stimulation on persistent post-concussion syndrome. Sci Rep. 2019;9:5498.PubMedPubMedCentralCrossRef Moussavi Z, Suleiman A, Rutherford G, Ranjbar Pouya O, Dastgheib Z, Zhang W, et al. A pilot randomised double-blind study of the tolerability and efficacy of repetitive transcranial magnetic stimulation on persistent post-concussion syndrome. Sci Rep. 2019;9:5498.PubMedPubMedCentralCrossRef
58.
Zurück zum Zitat Parain D, Chastan N. Large-field repetitive transcranial magnetic stimulation with circular coil in the treatment of functional neurological symptoms. Neurophysiol Clin. 2014;44:425–31.PubMedCrossRef Parain D, Chastan N. Large-field repetitive transcranial magnetic stimulation with circular coil in the treatment of functional neurological symptoms. Neurophysiol Clin. 2014;44:425–31.PubMedCrossRef
59.
Zurück zum Zitat Pollak TA, Nicholson TR, Edwards MJ, David AS. A systematic review of transcranial magnetic stimulation in the treatment of functional (conversion) neurological symptoms. J Neurol Neurosurg Psychiatry. 2014;85:191–7.PubMedCrossRef Pollak TA, Nicholson TR, Edwards MJ, David AS. A systematic review of transcranial magnetic stimulation in the treatment of functional (conversion) neurological symptoms. J Neurol Neurosurg Psychiatry. 2014;85:191–7.PubMedCrossRef
60.
Zurück zum Zitat Garcin B, Roze E, Mesrati F, Cognat E, Fournier E, Vidailhet M, et al. Transcranial magnetic stimulation as an efficient treatment for psychogenic movement disorders. J Neurol Neurosurg Psychiatry. 2013;84:1043–6.PubMedCrossRef Garcin B, Roze E, Mesrati F, Cognat E, Fournier E, Vidailhet M, et al. Transcranial magnetic stimulation as an efficient treatment for psychogenic movement disorders. J Neurol Neurosurg Psychiatry. 2013;84:1043–6.PubMedCrossRef
61.
Zurück zum Zitat Lai J-B, Han M-M, Xu Y, Hu S-H. Effective treatment of narcolepsy-like symptoms with high-frequency repetitive transcranial magnetic stimulation: a case report. Medicine (Baltimore). 2017;96:e8645.CrossRef Lai J-B, Han M-M, Xu Y, Hu S-H. Effective treatment of narcolepsy-like symptoms with high-frequency repetitive transcranial magnetic stimulation: a case report. Medicine (Baltimore). 2017;96:e8645.CrossRef
62.
Zurück zum Zitat Mylius V, Gerstner A, Peters M, Prokisch H, Leonhardt A, Hellwig D, et al. Low-frequency rTMS of the premotor cortex reduces complex movement patterns in a patient with pantothenate kinase-associated neurodegenerative disease (PKAN). Neurophysiol Clin. 2009;39:27–30.PubMedCrossRef Mylius V, Gerstner A, Peters M, Prokisch H, Leonhardt A, Hellwig D, et al. Low-frequency rTMS of the premotor cortex reduces complex movement patterns in a patient with pantothenate kinase-associated neurodegenerative disease (PKAN). Neurophysiol Clin. 2009;39:27–30.PubMedCrossRef
Metadaten
Titel
Transcranial Magnetic Stimulation for the Treatment of Pediatric Neurological Disorders
verfasst von
Laura A. Malone, MD, PhD
Lisa R. Sun, MD
Publikationsdatum
01.11.2019
Verlag
Springer US
Erschienen in
Current Treatment Options in Neurology / Ausgabe 11/2019
Print ISSN: 1092-8480
Elektronische ISSN: 1534-3138
DOI
https://doi.org/10.1007/s11940-019-0600-3

Weitere Artikel der Ausgabe 11/2019

Current Treatment Options in Neurology 11/2019 Zur Ausgabe

Sleep Disorders (A Iranzo, Section Editor)

Therapies for Restless Legs in Parkinson’s Disease

Multiple Sclerosis and Related Disorders (J Graves, Section Editor)

Functional Electrical Stimulation Cycling Exercise for People with Multiple Sclerosis

Critical Care Neurology (H Hinson, Section Editor)

Delirium Management in the ICU

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Nicht Creutzfeldt Jakob, sondern Abführtee-Vergiftung

29.05.2024 Hyponatriämie Nachrichten

Eine ältere Frau trinkt regelmäßig Sennesblättertee gegen ihre Verstopfung. Der scheint plötzlich gut zu wirken. Auf Durchfall und Erbrechen folgt allerdings eine Hyponatriämie. Nach deren Korrektur kommt es plötzlich zu progredienten Kognitions- und Verhaltensstörungen.

Schutz der Synapsen bei Alzheimer

29.05.2024 Morbus Alzheimer Nachrichten

Mit einem Neurotrophin-Rezeptor-Modulator lässt sich möglicherweise eine bestehende Alzheimerdemenz etwas abschwächen: Erste Phase-2-Daten deuten auf einen verbesserten Synapsenschutz.

Sozialer Aufstieg verringert Demenzgefahr

24.05.2024 Demenz Nachrichten

Ein hohes soziales Niveau ist mit die beste Versicherung gegen eine Demenz. Noch geringer ist das Demenzrisiko für Menschen, die sozial aufsteigen: Sie gewinnen fast zwei demenzfreie Lebensjahre. Umgekehrt steigt die Demenzgefahr beim sozialen Abstieg.

Hirnblutung unter DOAK und VKA ähnlich bedrohlich

17.05.2024 Direkte orale Antikoagulanzien Nachrichten

Kommt es zu einer nichttraumatischen Hirnblutung, spielt es keine große Rolle, ob die Betroffenen zuvor direkt wirksame orale Antikoagulanzien oder Marcumar bekommen haben: Die Prognose ist ähnlich schlecht.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.