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30.09.2020 | COVID-19 | Reflections from the COVID Pandemic (A Iranzo and M Rosenfeld, Section Editors) Zur Zeit gratis

Unraveling the Possible Routes of SARS-COV-2 Invasion into the Central Nervous System

verfasst von: Maria Lima, MD, Vasileios Siokas, MD, PhD, Athina-Maria Aloizou, MD, Ioannis Liampas, MD, MSc, Alexios-Fotios A. Mentis, MD, PhD, PMC, MPH, Zisis Tsouris, MD, MSc, Anastasios Papadimitriou, MD, Panayiotis D. Mitsias, MD, PhD, Aristidis Tsatsakis, PhD, DSc, Dimitrios P. Bogdanos, MBA, MD, PhD, Stavros J. Baloyannis, MD, PhD, Efthimios Dardiotis, MD, PhD

Erschienen in: Current Treatment Options in Neurology | Ausgabe 11/2020

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Abstract

Purpose of Review

To describe the possible neuroinvasion pathways of Severe Acute Respiratory Syndrome-related Coronavirus-2 (SARS-CoV-2), the virus responsible for the Coronavirus disease-19 (Covid-19) pandemic.

Recent Findings

We present data regarding the family of Coronaviruses (CoVs) and the central nervous system (CNS), and describe parallels between SARS-CoV-2 and other members of the family, which have been investigated in more depth and combine these findings with the recent advancements regarding SARS-CoV-2.

Summary

SARS-CoV-2 like other CoVs is neuroinvasive, neurotropic and neurovirulent. Two main pathways of CNS penetration seem to be the strongest candidates, the hematogenous and the neuronal. Τhe olfactory route in particular appears to play a significant role in neuroinvasion of coronaviruses and SARS-CoV-2, as well. However, existing data suggest that other routes, involving the nasal epithelium in general, lymphatic tissue and the CSF may also play roles in SARS-CoV-2 invasion into the CNS.

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Titel: Unraveling the Possible Routes of SARS-COV-2 Invasion into the Central Nervous System
verfasst von: Maria Lima, MD
Vasileios Siokas, MD, PhD
Athina-Maria Aloizou, MD
Ioannis Liampas, MD, MSc
Alexios-Fotios A. Mentis, MD, PhD, PMC, MPH
Zisis Tsouris, MD, MSc
Anastasios Papadimitriou, MD
Panayiotis D. Mitsias, MD, PhD
Aristidis Tsatsakis, PhD, DSc
Dimitrios P. Bogdanos, MBA, MD, PhD
Stavros J. Baloyannis, MD, PhD
Efthimios Dardiotis, MD, PhD
Publikationsdatum: 30.09.2020
Verlag: Springer US
Schlagwort: COVID-19
Erschienen in: Current Treatment Options in Neurology / Ausgabe 11/2020
Print ISSN: 1092-8480
Elektronische ISSN: 1534-3138
DOI: https://doi.org/10.1007/s11940-020-00647-z

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