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Clinical Reviews in Allergy & Immunology

Erschienen in:

01.06.2009

Revisiting Libman–Sacks Endocarditis: A Historical Review and Update

verfasst von: Jennifer L. Lee, Stanley M. Naguwa, Gurtej S. Cheema, M. Eric Gershwin

Erschienen in: Clinical Reviews in Allergy & Immunology | Ausgabe 2-3/2009

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Abstract

Libman–Sacks (LS) endocarditis was first described by Libman and Sacks in 1924, and is characterized by sterile, verrucous valvular lesions with a predisposition for the mitral and aortic valves. It is now regarded as both a cardiac manifestation of systemic lupus erythematosus and, in recent years, of the antiphospholipid syndrome (APS). Though typically mild and asymptomatic, LS endocarditis can lead to significant complications, including severe valvular insufficiency requiring surgery, infective endocarditis, and thromboembolic events, such as stroke and transient ischemic events. Improvements in imaging modalities, particularly in echocardiography, have allowed better estimation of the prevalence of the disease, but further investigation is still needed into its pathogenesis, treatment, and association with APS.

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Titel: Revisiting Libman–Sacks Endocarditis: A Historical Review and Update
verfasst von: Jennifer L. Lee
Stanley M. Naguwa
Gurtej S. Cheema
M. Eric Gershwin
Publikationsdatum: 01.06.2009
Verlag: Humana Press Inc
Erschienen in: Clinical Reviews in Allergy & Immunology / Ausgabe 2-3/2009
Print ISSN: 1080-0549
Elektronische ISSN: 1559-0267
DOI: https://doi.org/10.1007/s12016-008-8113-y

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