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Erschienen in: Neurocritical Care 2/2007

01.10.2007 | Original Paper

Therapeutic Hypothermia after Cardiac Arrest: Performance Characteristics and Safety of Surface Cooling with or without Endovascular Cooling

verfasst von: Alexander C. Flint, J. Claude Hemphill, David C. Bonovich

Erschienen in: Neurocritical Care | Ausgabe 2/2007

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Abstract

Introduction

Various methods are available to induce and maintain therapeutic hypothermia after cardiac arrest, but little data is available comparing device-mediated cooling to simple surface methods in this setting.

Methods

To assess the performance characteristics of simple surface cooling with or without an endovascular cooling catheter system, we retrospectively reviewed all cases of hypothermia for comatose survivors of cardiac arrest treated at a single academically affiliated urban hospital. Forty two comatose survivors of cardiac arrest were treated over a 3.5-year period. Hypothermia was induced and maintained by simple surface methods (ice packs, cooling blankets) with or without placement of an endovascular cooling catheter system with automated temperature feedback regulation.

Results

Overall, the rate of active cooling was not different between patients treated with endovascular catheter-assisted hypothermia and patients treated with surface cooling alone. However, use of a larger (14 F) catheter was associated with faster cooling rates. Maintenance of goal temperature (33°C) was far better controlled with the use of a cooling catheter. Use of surface cooling alone was associated with significant temperature overshoot. Patients treated with surface cooling alone spent more time bradycardic.

Conclusion

Use of an endovascular cooling catheter as part of a treatment protocol for hypothermia after cardiac arrest provides better control during maintenance of hypothermia, preventing temperature overshoot. Active cooling rates may be enhanced by the use of a larger cooling catheter.
Literatur
1.
Zurück zum Zitat Williams GR Jr, Spencer FC. The clinical use of hypothermia following cardiac arrest. Ann Surg 1958;148(3):462–8.PubMedCrossRef Williams GR Jr, Spencer FC. The clinical use of hypothermia following cardiac arrest. Ann Surg 1958;148(3):462–8.PubMedCrossRef
2.
Zurück zum Zitat Benson DW, Williams GR Jr., Spencer FC, Yates AJ. The use of hypothermia after cardiac arrest. Anesth Analg 1959;38:423–8.PubMedCrossRef Benson DW, Williams GR Jr., Spencer FC, Yates AJ. The use of hypothermia after cardiac arrest. Anesth Analg 1959;38:423–8.PubMedCrossRef
3.
Zurück zum Zitat Feldman E, Rubin B, Surks SN. Beneficial effects of hypothermia after cardiac arrest. JAMA 1960;173:499–501.PubMed Feldman E, Rubin B, Surks SN. Beneficial effects of hypothermia after cardiac arrest. JAMA 1960;173:499–501.PubMed
4.
Zurück zum Zitat Bernard SA, Gray TW, Buist MD, et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 2002;346(8):557–63.PubMedCrossRef Bernard SA, Gray TW, Buist MD, et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 2002;346(8):557–63.PubMedCrossRef
5.
Zurück zum Zitat Group HS. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002;346(8):549–56.CrossRef Group HS. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002;346(8):549–56.CrossRef
6.
Zurück zum Zitat Holzer M, Bernard SA, Hachimi-Idrissi S, Roine RO, Sterz F, Mullner M. Hypothermia for neuroprotection after cardiac arrest: systematic review and individual patient data meta-analysis. Crit Care Med 2005;33(2):414–8.PubMedCrossRef Holzer M, Bernard SA, Hachimi-Idrissi S, Roine RO, Sterz F, Mullner M. Hypothermia for neuroprotection after cardiac arrest: systematic review and individual patient data meta-analysis. Crit Care Med 2005;33(2):414–8.PubMedCrossRef
7.
Zurück zum Zitat American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Part 7.5: Postresuscitation Support. Circulation 2005;112(24_suppl):IV-84–8. American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Part 7.5: Postresuscitation Support. Circulation 2005;112(24_suppl):IV-84–8.
8.
Zurück zum Zitat Hazinski MF, Nadkarni VM, Hickey RW, O’Connor R, Becker LB, Zaritsky A. Major changes in the 2005 AHA Guidelines for CPR, ECC: reaching the tipping point for change. Circulation 2005;112(24 Suppl):IV206–11.PubMed Hazinski MF, Nadkarni VM, Hickey RW, O’Connor R, Becker LB, Zaritsky A. Major changes in the 2005 AHA Guidelines for CPR, ECC: reaching the tipping point for change. Circulation 2005;112(24 Suppl):IV206–11.PubMed
9.
Zurück zum Zitat Nolan JP, Morley PT, Hoek TL, Hickey RW. Therapeutic hypothermia after cardiac arrest. An advisory statement by the Advancement Life support Task Force of the International Liaison committee on Resuscitation. Resuscitation 2003;57(3):231–5.PubMedCrossRef Nolan JP, Morley PT, Hoek TL, Hickey RW. Therapeutic hypothermia after cardiac arrest. An advisory statement by the Advancement Life support Task Force of the International Liaison committee on Resuscitation. Resuscitation 2003;57(3):231–5.PubMedCrossRef
10.
Zurück zum Zitat Bernard S. Therapeutic hypothermia after cardiac arrest: now a standard of care. Crit Care Med 2006;34(3):923–4.PubMedCrossRef Bernard S. Therapeutic hypothermia after cardiac arrest: now a standard of care. Crit Care Med 2006;34(3):923–4.PubMedCrossRef
11.
Zurück zum Zitat Bernard SA. Therapeutic hypothermia after cardiac arrest. Hypothermia is now standard care for some types of cardiac arrest. Med J Aust 2004;181(9):468–9.PubMed Bernard SA. Therapeutic hypothermia after cardiac arrest. Hypothermia is now standard care for some types of cardiac arrest. Med J Aust 2004;181(9):468–9.PubMed
12.
Zurück zum Zitat Rincon F, Mayer SA. Therapeutic hypothermia for brain injury after cardiac arrest. Semin Neurol 2006;26(4):387–95.PubMedCrossRef Rincon F, Mayer SA. Therapeutic hypothermia for brain injury after cardiac arrest. Semin Neurol 2006;26(4):387–95.PubMedCrossRef
13.
Zurück zum Zitat Topjian A, Nadkarni V. Cooling after cardiac arrest: have we reached the tipping point? Crit Care Med 2006;34(7):2017–8.PubMedCrossRef Topjian A, Nadkarni V. Cooling after cardiac arrest: have we reached the tipping point? Crit Care Med 2006;34(7):2017–8.PubMedCrossRef
14.
Zurück zum Zitat Merchant RM, Soar J, Skrifvars MB, et al. Therapeutic hypothermia utilization among physicians after resuscitation from cardiac arrest. Crit Care Med 2006;34(7):1935–40.PubMedCrossRef Merchant RM, Soar J, Skrifvars MB, et al. Therapeutic hypothermia utilization among physicians after resuscitation from cardiac arrest. Crit Care Med 2006;34(7):1935–40.PubMedCrossRef
15.
Zurück zum Zitat Abella BS, Rhee JW, Huang KN, Vanden Hoek TL, Becker LB. Induced hypothermia is underused after resuscitation from cardiac arrest: a current practice survey. Resuscitation 2005;64(2):181–6.PubMedCrossRef Abella BS, Rhee JW, Huang KN, Vanden Hoek TL, Becker LB. Induced hypothermia is underused after resuscitation from cardiac arrest: a current practice survey. Resuscitation 2005;64(2):181–6.PubMedCrossRef
16.
Zurück zum Zitat Sanders AB. Therapeutic hypothermia after cardiac arrest. Curr Opin Crit Care 2006;12(3):213–7.PubMedCrossRef Sanders AB. Therapeutic hypothermia after cardiac arrest. Curr Opin Crit Care 2006;12(3):213–7.PubMedCrossRef
17.
Zurück zum Zitat Zeiner A, Holzer M, Sterz F, et al. Mild resuscitative hypothermia to improve neurological outcome after cardiac arrest. A clinical feasibility trial. Hypothermia After Cardiac Arrest (HACA) Study Group. Stroke 2000;31(1):86–94.PubMed Zeiner A, Holzer M, Sterz F, et al. Mild resuscitative hypothermia to improve neurological outcome after cardiac arrest. A clinical feasibility trial. Hypothermia After Cardiac Arrest (HACA) Study Group. Stroke 2000;31(1):86–94.PubMed
18.
Zurück zum Zitat Yanagawa Y, Ishihara S, Norio H, et al. Preliminary clinical outcome study of mild resuscitative hypothermia after out-of-hospital cardiopulmonary arrest. Resuscitation 1998;39(1–2):61–6.PubMedCrossRef Yanagawa Y, Ishihara S, Norio H, et al. Preliminary clinical outcome study of mild resuscitative hypothermia after out-of-hospital cardiopulmonary arrest. Resuscitation 1998;39(1–2):61–6.PubMedCrossRef
19.
Zurück zum Zitat Moscucci M, Eagle KA. Reducing the door-to-balloon time for myocardial infarction with ST-segment elevation. N Engl J Med 2006;355(22):2364–5.PubMedCrossRef Moscucci M, Eagle KA. Reducing the door-to-balloon time for myocardial infarction with ST-segment elevation. N Engl J Med 2006;355(22):2364–5.PubMedCrossRef
20.
Zurück zum Zitat Grotta JC, Burgin WS, El-Mitwalli A, et al. Intravenous tissue-type plasminogen activator therapy for ischemic stroke: Houston experience 1996 to 2000. Arch Neurol 2001;58(12):2009–13.PubMedCrossRef Grotta JC, Burgin WS, El-Mitwalli A, et al. Intravenous tissue-type plasminogen activator therapy for ischemic stroke: Houston experience 1996 to 2000. Arch Neurol 2001;58(12):2009–13.PubMedCrossRef
21.
Zurück zum Zitat Gottesman RF, Alt J, Wityk RJ, Llinas RH. Predicting abnormal coagulation in ischemic stroke: reducing delay in rt-PA use. Neurology 2006;67(9):1665–7.PubMedCrossRef Gottesman RF, Alt J, Wityk RJ, Llinas RH. Predicting abnormal coagulation in ischemic stroke: reducing delay in rt-PA use. Neurology 2006;67(9):1665–7.PubMedCrossRef
22.
Zurück zum Zitat Felberg RA, Krieger DW, Chuang R, et al. Hypothermia after cardiac arrest: feasibility and safety of an external cooling protocol. Circulation 2001;104(15):1799–804.PubMed Felberg RA, Krieger DW, Chuang R, et al. Hypothermia after cardiac arrest: feasibility and safety of an external cooling protocol. Circulation 2001;104(15):1799–804.PubMed
23.
Zurück zum Zitat Bernard SA, Jones BM, Horne MK. Clinical trial of induced hypothermia in comatose survivors of out-of-hospital cardiac arrest. Ann Emerg Med 1997;30(2):146–53.PubMedCrossRef Bernard SA, Jones BM, Horne MK. Clinical trial of induced hypothermia in comatose survivors of out-of-hospital cardiac arrest. Ann Emerg Med 1997;30(2):146–53.PubMedCrossRef
24.
Zurück zum Zitat Hachimi-Idrissi S, Corne L, Ebinger G, Michotte Y, Huyghens L. Mild hypothermia induced by a helmet device: a clinical feasibility study. Resuscitation 2001;51(3):275–81.PubMedCrossRef Hachimi-Idrissi S, Corne L, Ebinger G, Michotte Y, Huyghens L. Mild hypothermia induced by a helmet device: a clinical feasibility study. Resuscitation 2001;51(3):275–81.PubMedCrossRef
25.
Zurück zum Zitat Callaway CW, Tadler SC, Katz LM, Lipinski CL, Brader E. Feasibility of external cranial cooling during out-of-hospital cardiac arrest. Resuscitation 2002;52(2):159–65.PubMedCrossRef Callaway CW, Tadler SC, Katz LM, Lipinski CL, Brader E. Feasibility of external cranial cooling during out-of-hospital cardiac arrest. Resuscitation 2002;52(2):159–65.PubMedCrossRef
26.
Zurück zum Zitat Bernard S, Buist M, Monteiro O, Smith K. Induced hypothermia using large volume, ice-cold intravenous fluid in comatose survivors of out-of-hospital cardiac arrest: a preliminary report. Resuscitation 2003;56(1):9–13.PubMedCrossRef Bernard S, Buist M, Monteiro O, Smith K. Induced hypothermia using large volume, ice-cold intravenous fluid in comatose survivors of out-of-hospital cardiac arrest: a preliminary report. Resuscitation 2003;56(1):9–13.PubMedCrossRef
27.
Zurück zum Zitat Xiao F, Safar P, Alexander H. Peritoneal cooling for mild cerebral hypothermia after cardiac arrest in dogs. Resuscitation 1995;30(1):51–9.PubMedCrossRef Xiao F, Safar P, Alexander H. Peritoneal cooling for mild cerebral hypothermia after cardiac arrest in dogs. Resuscitation 1995;30(1):51–9.PubMedCrossRef
28.
Zurück zum Zitat Mayer SA, Kowalski RG, Presciutti M, et al. Clinical trial of a novel surface cooling system for fever control in neurocritical care patients. Crit Care Med 2004;32(12):2508–15.PubMedCrossRef Mayer SA, Kowalski RG, Presciutti M, et al. Clinical trial of a novel surface cooling system for fever control in neurocritical care patients. Crit Care Med 2004;32(12):2508–15.PubMedCrossRef
29.
Zurück zum Zitat Holzer M, Mullner M, Sterz F, et al. Efficacy and safety of endovascular cooling after cardiac arrest: cohort study and Bayesian approach. Stroke 2006;37(7):1792–7.PubMedCrossRef Holzer M, Mullner M, Sterz F, et al. Efficacy and safety of endovascular cooling after cardiac arrest: cohort study and Bayesian approach. Stroke 2006;37(7):1792–7.PubMedCrossRef
30.
Zurück zum Zitat Kliegel A, Losert H, Sterz F, et al. Cold simple intravenous infusions preceding special endovascular cooling for faster induction of mild hypothermia after cardiac arrest–a feasibility study. Resuscitation 2005;64(3):347–51.PubMedCrossRef Kliegel A, Losert H, Sterz F, et al. Cold simple intravenous infusions preceding special endovascular cooling for faster induction of mild hypothermia after cardiac arrest–a feasibility study. Resuscitation 2005;64(3):347–51.PubMedCrossRef
31.
Zurück zum Zitat Al-Senani FM, Graffagnino C, Grotta JC, et al. A prospective, multicenter pilot study to evaluate the feasibility and safety of using the CoolGard System and Icy catheter following cardiac arrest. Resuscitation 2004;62(2):143–50.PubMedCrossRef Al-Senani FM, Graffagnino C, Grotta JC, et al. A prospective, multicenter pilot study to evaluate the feasibility and safety of using the CoolGard System and Icy catheter following cardiac arrest. Resuscitation 2004;62(2):143–50.PubMedCrossRef
32.
Zurück zum Zitat Merchant RM, Abella BS, Peberdy MA, et al. Therapeutic hypothermia after cardiac arrest: Unintentional overcooling is common using ice packs and conventional cooling blankets. Crit Care Med 2006;34(12 Suppl):S490–4.PubMedCrossRef Merchant RM, Abella BS, Peberdy MA, et al. Therapeutic hypothermia after cardiac arrest: Unintentional overcooling is common using ice packs and conventional cooling blankets. Crit Care Med 2006;34(12 Suppl):S490–4.PubMedCrossRef
33.
Zurück zum Zitat Arrich J. Clinical application of mild therapeutic hypothermia after cardiac arrest. Crit Care Med 2007;35(4):1041–7.PubMedCrossRef Arrich J. Clinical application of mild therapeutic hypothermia after cardiac arrest. Crit Care Med 2007;35(4):1041–7.PubMedCrossRef
34.
Zurück zum Zitat Kuboyama K, Safar P, Radovsky A, Tisherman SA, Stezoski SW, Alexander H. Delay in cooling negates the beneficial effect of mild resuscitative cerebral hypothermia after cardiac arrest in dogs: a prospective, randomized study. Crit Care Med 1993;21(9):1348–58.PubMedCrossRef Kuboyama K, Safar P, Radovsky A, Tisherman SA, Stezoski SW, Alexander H. Delay in cooling negates the beneficial effect of mild resuscitative cerebral hypothermia after cardiac arrest in dogs: a prospective, randomized study. Crit Care Med 1993;21(9):1348–58.PubMedCrossRef
35.
Zurück zum Zitat Nozari A, Safar P, Stezoski SW, et al. Critical time window for intra-arrest cooling with cold saline flush in a dog model of cardiopulmonary resuscitation. Circulation 2006;113(23):2690–6.PubMedCrossRef Nozari A, Safar P, Stezoski SW, et al. Critical time window for intra-arrest cooling with cold saline flush in a dog model of cardiopulmonary resuscitation. Circulation 2006;113(23):2690–6.PubMedCrossRef
Metadaten
Titel
Therapeutic Hypothermia after Cardiac Arrest: Performance Characteristics and Safety of Surface Cooling with or without Endovascular Cooling
verfasst von
Alexander C. Flint
J. Claude Hemphill
David C. Bonovich
Publikationsdatum
01.10.2007
Verlag
Humana Press Inc
Erschienen in
Neurocritical Care / Ausgabe 2/2007
Print ISSN: 1541-6933
Elektronische ISSN: 1556-0961
DOI
https://doi.org/10.1007/s12028-007-0068-y

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