Skip to main content
Erschienen in: The Indian Journal of Pediatrics 1/2014

01.09.2014 | Original Article

Public Health Implications of Obstructive Sleep Apnea Burden

verfasst von: Ileana Baldi, Achal Gulati, Giulia Lorenzoni, Kiran Natarajan, Simonetta Ballali, Mohan Kameswaran, Ranjith Rajeswaran, Dario Gregori, Gulshan Sethi

Erschienen in: Indian Journal of Pediatrics | Sonderheft 1/2014

Einloggen, um Zugang zu erhalten

Abstract

Objective

To assess the implications of obstructive sleep apnea (OSA) burden among Indian children.

Methods

MonteCarlo simulations were performed in order to estimate the number of OSA related obesity cases among Indian children (1–14 y of age) and the number of cases of stroke, coronary heart disease (CHD) and type 2 diabetes, considered as main adverse outcomes of OSA related childhood obesity, according to untreated and treated [adenotonsillectomy (AT) alone and AT associated to continuous positive airway pressure (CPAP)] pediatric OSA. Data used to perform MonteCarlo simulations were derived from a review about current literature exploring OSA related obesity.

Results

The analysis on the number of adverse outcomes according to treated and untreated obesity related to OSA showed that treatments reduce the number of obesity cases, resulting in a great reduction of the amount of stroke, CHD and type 2 diabetes cases. However, the cost for treating adverse outcome was higher in patients treated for obesity related to OSA compared to those not receiving any treatment.

Conclusions

The reduction in the number of adverse outcomes due to treatment of obesity related OSA implicates the urgent need for public health policies in providing screening for OSA among children population: an early detection and a consequently prompt reaction to pediatric OSA could improve the burden of OSA related obesity.
Literatur
1.
Zurück zum Zitat American Thoracic Society. Standards and indications for cardiopulmonary sleep studies in children. Am J Resp Crit Care Med. 1996;153:866–78.CrossRef American Thoracic Society. Standards and indications for cardiopulmonary sleep studies in children. Am J Resp Crit Care Med. 1996;153:866–78.CrossRef
2.
Zurück zum Zitat Bixler EO, Vgontzas AN, Lin HM, Liao D, Calhoun S, Vela-Bueno A, et al. Sleep disordered breathing in children in a general population sample: prevalence and risk factors. Sleep. 2009;32:731–6.PubMedPubMedCentral Bixler EO, Vgontzas AN, Lin HM, Liao D, Calhoun S, Vela-Bueno A, et al. Sleep disordered breathing in children in a general population sample: prevalence and risk factors. Sleep. 2009;32:731–6.PubMedPubMedCentral
3.
Zurück zum Zitat Anuntaseree W, Kuasirikul S, Suntornlohanakul S. Natural history of snoring and obstructive sleep apnea in thai school-age children. Pediatr Pulmonol. 2005;39:415–20.PubMedCrossRef Anuntaseree W, Kuasirikul S, Suntornlohanakul S. Natural history of snoring and obstructive sleep apnea in thai school-age children. Pediatr Pulmonol. 2005;39:415–20.PubMedCrossRef
4.
Zurück zum Zitat Brunetti L, Rana S, Lospalluti ML, Pietrafesa A, Francavilla R, Fanelli M, et al. Prevalence of obstructive sleep apnea syndrome in a cohort of 1,207 children of southern Italy. Chest. 2001;120:1930–5.PubMedCrossRef Brunetti L, Rana S, Lospalluti ML, Pietrafesa A, Francavilla R, Fanelli M, et al. Prevalence of obstructive sleep apnea syndrome in a cohort of 1,207 children of southern Italy. Chest. 2001;120:1930–5.PubMedCrossRef
5.
Zurück zum Zitat Li AM, So HK, Au CT, Ho C, Lau J, Ng SK, et al. Epidemiology of obstructive sleep apnoea syndrome in chinese children: a two-phase community study. Thorax. 2010;65:991–7.PubMedCrossRef Li AM, So HK, Au CT, Ho C, Lau J, Ng SK, et al. Epidemiology of obstructive sleep apnoea syndrome in chinese children: a two-phase community study. Thorax. 2010;65:991–7.PubMedCrossRef
6.
Zurück zum Zitat Sogut A, Altin R, Uzun L, Ugur MB, Tomac N, Acun C, et al. Prevalence of obstructive sleep apnea syndrome and associated symptoms in 3–11-year-old turkish children. Pediatr Pulmonol. 2005;39:251–6.PubMedCrossRef Sogut A, Altin R, Uzun L, Ugur MB, Tomac N, Acun C, et al. Prevalence of obstructive sleep apnea syndrome and associated symptoms in 3–11-year-old turkish children. Pediatr Pulmonol. 2005;39:251–6.PubMedCrossRef
7.
Zurück zum Zitat Kaditis AG, Finder J, Alexopoulos EI, Starantzis K, Tanou K, Gampeta S, et al. Sleep-disordered breathing in 3,680 greek children. Pediatr Pulmonol. 2004;37:499–509.PubMedCrossRef Kaditis AG, Finder J, Alexopoulos EI, Starantzis K, Tanou K, Gampeta S, et al. Sleep-disordered breathing in 3,680 greek children. Pediatr Pulmonol. 2004;37:499–509.PubMedCrossRef
8.
Zurück zum Zitat Anuntaseree W, Rookkapan K, Kuasirikul S, Thongsuksai P. Snoring and obstructive sleep apnea in thai school-age children: prevalence and predisposing factors. Pediatr Pulmonol. 2001;32:222–7.PubMedCrossRef Anuntaseree W, Rookkapan K, Kuasirikul S, Thongsuksai P. Snoring and obstructive sleep apnea in thai school-age children: prevalence and predisposing factors. Pediatr Pulmonol. 2001;32:222–7.PubMedCrossRef
9.
Zurück zum Zitat Padez C, Mourao I, Moreira P, Rosado V. Long sleep duration and childhood overweight/obesity and body fat. Am J Hum Biol. 2009;21:371–6.PubMedCrossRef Padez C, Mourao I, Moreira P, Rosado V. Long sleep duration and childhood overweight/obesity and body fat. Am J Hum Biol. 2009;21:371–6.PubMedCrossRef
10.
Zurück zum Zitat von Kries R, Toschke AM, Wurmser H, Sauerwald T, Koletzko B. Reduced risk for overweight and obesity in 5- and 6-y-old children by duration of sleep–a cross-sectional study. Int J Obes Relat Metab Disord. 2002;26:710–6.CrossRef von Kries R, Toschke AM, Wurmser H, Sauerwald T, Koletzko B. Reduced risk for overweight and obesity in 5- and 6-y-old children by duration of sleep–a cross-sectional study. Int J Obes Relat Metab Disord. 2002;26:710–6.CrossRef
11.
Zurück zum Zitat Sekine M, Yamagami T, Handa K, Saito T, Nanri S, Kawaminami K, et al. A dose–response relationship between short sleeping hours and childhood obesity: results of the toyama birth cohort study. Child Care Health Dev. 2002;28:163–70.PubMedCrossRef Sekine M, Yamagami T, Handa K, Saito T, Nanri S, Kawaminami K, et al. A dose–response relationship between short sleeping hours and childhood obesity: results of the toyama birth cohort study. Child Care Health Dev. 2002;28:163–70.PubMedCrossRef
13.
Zurück zum Zitat Kelsey MM, Zaepfel A, Bjornstad P, Nadeau KJ. Age-related consequences of childhood obesity. Gerontology. 2014;60:222–8.PubMedCrossRef Kelsey MM, Zaepfel A, Bjornstad P, Nadeau KJ. Age-related consequences of childhood obesity. Gerontology. 2014;60:222–8.PubMedCrossRef
14.
Zurück zum Zitat Lloyd LJ, Langley-Evans SC, McMullen S. Childhood obesity and adult cardiovascular disease risk: a systematic review. Int J Obes. 2010;34:18–28.CrossRef Lloyd LJ, Langley-Evans SC, McMullen S. Childhood obesity and adult cardiovascular disease risk: a systematic review. Int J Obes. 2010;34:18–28.CrossRef
15.
Zurück zum Zitat Al Mamun A, Cramb SM, O’Callaghan MJ, Williams GM, Najman JM. Childhood overweight status predicts diabetes at age 21 years: a follow-up study. Obesity. 2009;17:1255–61.PubMedCrossRef Al Mamun A, Cramb SM, O’Callaghan MJ, Williams GM, Najman JM. Childhood overweight status predicts diabetes at age 21 years: a follow-up study. Obesity. 2009;17:1255–61.PubMedCrossRef
16.
Zurück zum Zitat Gupta N, Goel K, Shah P, Misra A. Childhood obesity in developing countries: epidemiology, determinants, and prevention. Endocr Rev. 2012;33:48–70.PubMedCrossRef Gupta N, Goel K, Shah P, Misra A. Childhood obesity in developing countries: epidemiology, determinants, and prevention. Endocr Rev. 2012;33:48–70.PubMedCrossRef
17.
Zurück zum Zitat Reddy KS, Yusuf S. Emerging epidemic of cardiovascular disease in developing countries. Circulation. 1998;97:596–601.PubMedCrossRef Reddy KS, Yusuf S. Emerging epidemic of cardiovascular disease in developing countries. Circulation. 1998;97:596–601.PubMedCrossRef
18.
Zurück zum Zitat Mohan V, Sandeep S, Deepa R, Shah B, Varghese C. Epidemiology of type 2 diabetes: Indian scenario. Indian J Med Res. 2007;125:217–30.PubMed Mohan V, Sandeep S, Deepa R, Shah B, Varghese C. Epidemiology of type 2 diabetes: Indian scenario. Indian J Med Res. 2007;125:217–30.PubMed
19.
Zurück zum Zitat Agrawal S, Sharma SK, Sreenivas V, Lakshmy R. Prevalence of metabolic syndrome in a north Indian hospital-based population with obstructive sleep apnoea. Indian J Med Res. 2011;134:639–44.PubMedCrossRefPubMedCentral Agrawal S, Sharma SK, Sreenivas V, Lakshmy R. Prevalence of metabolic syndrome in a north Indian hospital-based population with obstructive sleep apnoea. Indian J Med Res. 2011;134:639–44.PubMedCrossRefPubMedCentral
20.
Zurück zum Zitat Sharma SK, Kumpawat S, Banga A, Goel A. Prevalence and risk factors of obstructive sleep apnea syndrome in a population of Delhi. India Chest. 2006;130:149–56.CrossRef Sharma SK, Kumpawat S, Banga A, Goel A. Prevalence and risk factors of obstructive sleep apnea syndrome in a population of Delhi. India Chest. 2006;130:149–56.CrossRef
21.
Zurück zum Zitat Udwadia ZF, Doshi AV, Lonkar SG, Singh CI. Prevalence of sleep-disordered breathing and sleep apnea in middle-aged urban indian men. Am J Respir Crit Care Med. 2004;169:168–73.PubMedCrossRef Udwadia ZF, Doshi AV, Lonkar SG, Singh CI. Prevalence of sleep-disordered breathing and sleep apnea in middle-aged urban indian men. Am J Respir Crit Care Med. 2004;169:168–73.PubMedCrossRef
22.
Zurück zum Zitat Kohler M, Lushington K, Couper R, Martin J, van den Heuvel C, Pamula Y, et al. Obesity and risk of sleep related upper airway obstruction in caucasian children. J Clin SleepMed. 2008;4:129–36. Kohler M, Lushington K, Couper R, Martin J, van den Heuvel C, Pamula Y, et al. Obesity and risk of sleep related upper airway obstruction in caucasian children. J Clin SleepMed. 2008;4:129–36.
23.
Zurück zum Zitat Rudnick EF, Walsh JS, Hampton MC, Mitchell RB. Prevalence and ethnicity of sleep-disordered breathing and obesity in children. Otolaryngol Head Neck Surg. 2007;137:878–82.PubMedCrossRef Rudnick EF, Walsh JS, Hampton MC, Mitchell RB. Prevalence and ethnicity of sleep-disordered breathing and obesity in children. Otolaryngol Head Neck Surg. 2007;137:878–82.PubMedCrossRef
24.
Zurück zum Zitat Weinstock TG, Rosen CL, Marcus CL, Garetz S, Mitchell RB, Amin R, et al. Predictors of obstructive sleep apnea severity in adenotonsillectomy candidates. Sleep. 2014;37:261–9.PubMedPubMedCentral Weinstock TG, Rosen CL, Marcus CL, Garetz S, Mitchell RB, Amin R, et al. Predictors of obstructive sleep apnea severity in adenotonsillectomy candidates. Sleep. 2014;37:261–9.PubMedPubMedCentral
25.
Zurück zum Zitat Marcus CL, Ward SL, Mallory GB, Rosen CL, Beckerman RC, Weese-Mayer DE, et al. Use of nasal continuous positive airway pressure as treatment of childhood obstructive sleep apnea. J Pediatr. 1995;127:88–94.PubMedCrossRef Marcus CL, Ward SL, Mallory GB, Rosen CL, Beckerman RC, Weese-Mayer DE, et al. Use of nasal continuous positive airway pressure as treatment of childhood obstructive sleep apnea. J Pediatr. 1995;127:88–94.PubMedCrossRef
26.
Zurück zum Zitat Lawlor DA, Leon DA. Association of body mass index and obesity measured in early childhood with risk of coronary heart disease and stroke in middle age: findings from the aberdeen children of the 1950s prospective cohort study. Circulation. 2005;111:1891–6.PubMedCrossRef Lawlor DA, Leon DA. Association of body mass index and obesity measured in early childhood with risk of coronary heart disease and stroke in middle age: findings from the aberdeen children of the 1950s prospective cohort study. Circulation. 2005;111:1891–6.PubMedCrossRef
27.
Zurück zum Zitat Mohan V, Venkatraman JV, Pradeepa R. Epidemiology of cardiovascular disease in type 2 diabetes: the indian scenario. J Diabetes Sci Technol. 2010;4:158–70.PubMedCrossRefPubMedCentral Mohan V, Venkatraman JV, Pradeepa R. Epidemiology of cardiovascular disease in type 2 diabetes: the indian scenario. J Diabetes Sci Technol. 2010;4:158–70.PubMedCrossRefPubMedCentral
28.
Zurück zum Zitat Morrison JA, Glueck CJ, Horn PS, Wang P. Childhood predictors of adult type 2 diabetes at 9- and 26-year follow-ups. Arch Pediatr Adolesc Med. 2010;164:53–60.PubMedCrossRef Morrison JA, Glueck CJ, Horn PS, Wang P. Childhood predictors of adult type 2 diabetes at 9- and 26-year follow-ups. Arch Pediatr Adolesc Med. 2010;164:53–60.PubMedCrossRef
29.
Zurück zum Zitat Cappuccio FP, Taggart FM, Kandala NB, Currie A, Peile E, Stranges S, et al. Meta-analysis of short sleep duration and obesity in children and adults. Sleep. 2008;31:619–26.PubMedPubMedCentral Cappuccio FP, Taggart FM, Kandala NB, Currie A, Peile E, Stranges S, et al. Meta-analysis of short sleep duration and obesity in children and adults. Sleep. 2008;31:619–26.PubMedPubMedCentral
30.
Zurück zum Zitat Meier JD, Duval M, Wilkes J, Andrews S, Korgenski EK, Park AH, et al. Surgeon dependent variation in adenotonsillectomy costs in children. Otolaryngol Head Neck Surg. 2014;150:887–92.PubMedCrossRef Meier JD, Duval M, Wilkes J, Andrews S, Korgenski EK, Park AH, et al. Surgeon dependent variation in adenotonsillectomy costs in children. Otolaryngol Head Neck Surg. 2014;150:887–92.PubMedCrossRef
31.
Zurück zum Zitat Kwatra G, Kaur P, Toor G, Badyal DK, Kaur R, Singh Y, et al. Cost of stroke from a tertiary center in northwest India. Neurol India. 2013;61:627–32.PubMedCrossRef Kwatra G, Kaur P, Toor G, Badyal DK, Kaur R, Singh Y, et al. Cost of stroke from a tertiary center in northwest India. Neurol India. 2013;61:627–32.PubMedCrossRef
32.
Zurück zum Zitat Kumpatla S, Kothandan H, Tharkar S, Viswanathan V. The costs of treating long-term diabetic complications in a developing country: a study from India. J Assoc Physicians India. 2013;61:102–9.PubMed Kumpatla S, Kothandan H, Tharkar S, Viswanathan V. The costs of treating long-term diabetic complications in a developing country: a study from India. J Assoc Physicians India. 2013;61:102–9.PubMed
33.
Zurück zum Zitat Katz ES, Mitchell RB, D’Ambrosio CM. Obstructive sleep apnea in infants. Am J Respir Crit Care Med. 2012;185:805–16.PubMedCrossRef Katz ES, Mitchell RB, D’Ambrosio CM. Obstructive sleep apnea in infants. Am J Respir Crit Care Med. 2012;185:805–16.PubMedCrossRef
34.
Zurück zum Zitat Marcus CL, Brooks LJ, Draper KA, Gozal D, Halbower AC, Jones J, et al. Diagnosis and management of childhood obstructive sleep apnea syndrome. Pediatrics. 2012;130:576–84.PubMedCrossRef Marcus CL, Brooks LJ, Draper KA, Gozal D, Halbower AC, Jones J, et al. Diagnosis and management of childhood obstructive sleep apnea syndrome. Pediatrics. 2012;130:576–84.PubMedCrossRef
35.
Zurück zum Zitat Tan HL, Gozal D, Ramirez HM, Bandla HP, Kheirandish-Gozal L. Overnight polysomnography versus respiratory polygraphy in the diagnosis of pediatric obstructive sleep apnea. Sleep. 2014;37:255–60.PubMedPubMedCentral Tan HL, Gozal D, Ramirez HM, Bandla HP, Kheirandish-Gozal L. Overnight polysomnography versus respiratory polygraphy in the diagnosis of pediatric obstructive sleep apnea. Sleep. 2014;37:255–60.PubMedPubMedCentral
37.
Zurück zum Zitat Kumaraswamy P. A generalized probability density function for double-bounded random processes. J Hydrol. 1980;46:79–88.CrossRef Kumaraswamy P. A generalized probability density function for double-bounded random processes. J Hydrol. 1980;46:79–88.CrossRef
38.
Zurück zum Zitat Van Hauwermeiren M, Vose D, Vanden Bossche S. A Compendium of distributions. In: Software V, ed. Belgium: Ghent; 2012. Van Hauwermeiren M, Vose D, Vanden Bossche S. A Compendium of distributions. In: Software V, ed. Belgium: Ghent; 2012.
39.
Zurück zum Zitat Seetho IW, Wilding JP. Screening for obstructive sleep apnoea in obesity and diabetes–potential for future approaches. Eur J Clin Invest. 2013;43:640–55.PubMedCrossRef Seetho IW, Wilding JP. Screening for obstructive sleep apnoea in obesity and diabetes–potential for future approaches. Eur J Clin Invest. 2013;43:640–55.PubMedCrossRef
40.
Zurück zum Zitat Poirier P, Giles TD, Bray GA, Hong Y, Stern JS, Pi-Sunyer FX, et al. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 american heart association scientific statement on obesity and heart disease from the obesity committee of the council on nutrition, physical activity, and metabolism. Circulation. 2006;113:898–918.PubMedCrossRef Poirier P, Giles TD, Bray GA, Hong Y, Stern JS, Pi-Sunyer FX, et al. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 american heart association scientific statement on obesity and heart disease from the obesity committee of the council on nutrition, physical activity, and metabolism. Circulation. 2006;113:898–918.PubMedCrossRef
Metadaten
Titel
Public Health Implications of Obstructive Sleep Apnea Burden
verfasst von
Ileana Baldi
Achal Gulati
Giulia Lorenzoni
Kiran Natarajan
Simonetta Ballali
Mohan Kameswaran
Ranjith Rajeswaran
Dario Gregori
Gulshan Sethi
Publikationsdatum
01.09.2014
Verlag
Springer India
Erschienen in
Indian Journal of Pediatrics / Ausgabe Sonderheft 1/2014
Print ISSN: 0019-5456
Elektronische ISSN: 0973-7693
DOI
https://doi.org/10.1007/s12098-014-1539-8

Weitere Artikel der Sonderheft 1/2014

The Indian Journal of Pediatrics 1/2014 Zur Ausgabe

Bei Amblyopie früher abkleben als bisher empfohlen?

22.05.2024 Fehlsichtigkeit Nachrichten

Bei Amblyopie ist das frühzeitige Abkleben des kontralateralen Auges in den meisten Fällen wohl effektiver als der Therapiestandard mit zunächst mehrmonatigem Brilletragen.

„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

17.05.2024 Klinik aktuell Nachrichten

Sie sei „ethisch geboten“, meint Gesundheitsminister Karl Lauterbach: mehr Transparenz über die Qualität von Klinikbehandlungen. Um sie abzubilden, lässt er gegen den Widerstand vieler Länder einen virtuellen Klinik-Atlas freischalten.

ADHS-Medikation erhöht das kardiovaskuläre Risiko

16.05.2024 Herzinsuffizienz Nachrichten

Erwachsene, die Medikamente gegen das Aufmerksamkeitsdefizit-Hyperaktivitätssyndrom einnehmen, laufen offenbar erhöhte Gefahr, an Herzschwäche zu erkranken oder einen Schlaganfall zu erleiden. Es scheint eine Dosis-Wirkungs-Beziehung zu bestehen.

Erstmanifestation eines Diabetes-Typ-1 bei Kindern: Ein Notfall!

16.05.2024 DDG-Jahrestagung 2024 Kongressbericht

Manifestiert sich ein Typ-1-Diabetes bei Kindern, ist das ein Notfall – ebenso wie eine diabetische Ketoazidose. Die Grundsäulen der Therapie bestehen aus Rehydratation, Insulin und Kaliumgabe. Insulin ist das Medikament der Wahl zur Behandlung der Ketoazidose.

Update Pädiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.