nach oben

Head and Neck Pathology

Erschienen in:

24.07.2017 | Sine qua non Clinicopathologic Correlation

Large Cell Transformation of Oral Mycosis Fungoides

verfasst von: Ahmed S. Sultan, Behzad Mostoufi, John C. Papadimitriou, Rima Koka, John Basile, Rania H. Younis

Erschienen in: Head and Neck Pathology | Ausgabe 2/2018

Einloggen, um Zugang zu erhalten

Abstract

Mycosis fungoides (MF) accounts for approximately 50% of all primary cutaneous lymphomas. MF occurrence in the oral cavity is extremely rare with approximately 45 cases reported to date. We present a case of a 68 year-old man with a raised nodular lesion of the ventral tongue with clinical impression of irritational fibroma. Histopathologic and immunohistochemical (IHC) examination revealed a phenotype consistent with MF with large cell transformation in the context of Sezary syndrome. The histological diagnosis of oral MF requires a high index of suspicion and IHC panel to rule out large cell transformation. To our knowledge, only four cases of large cell transformation of oral MF have been reported in the English literature. The clinical and histopathologic features of a rare case of intra-oral MF with large cell transformation are exemplified in this article.

Kadin ME, Hughey LC, Wood GS. Large-cell transformation of mycosis fungoides-differential diagnosis with implications for clinical management: a consensus statement of the US Cutaneous Lymphoma Consortium. J Am Acad Dermatol. 2014;70(2):374–6. doi:10.1016/j.jaad.2013.09.007.CrossRefPubMed

Zapater E, Bagan JV, Carbonell F, Basterra J. Malignant lymphoma of the head and neck. Oral Dis. 2010;16(2):119–28. doi:10.1111/j.1601-0825.2009.01586.x.CrossRefPubMed

Scherfler S, Freier K, Seeberger R, Bacon C, Hoffmann J, Thiele OC. Cranio-maxillofacial non-Hodgkin’s lymphoma: clinical and histological presentation. J Craniomaxillofac Surg. 2012;40(7):e211–e3. doi:10.1016/j.jcms.2011.10.021.CrossRefPubMed

Swerdlow SH, International Agency for Research on Cancer, World Health Organization. WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. Lyon: International Agency for Research on Cancer; 2008.

Chi AC, Neville BW, Damm DD, Allen CM. Oral and maxillofacial pathology. 4th ed. St. Louis: Elsevier; 2016.

Goldsmith SM, Seo BL, de Silva RK, Parachuru P, Rich AM, Seymour GJ. Oral mycosis fungoides: report with immune profile. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;118(2):e48–e52. doi:10.1016/j.oooo.2013.10.005.CrossRefPubMed

Wain EM, Setterfield J, Judge MR, Harper JI, Pemberton MN, Russell-Jones R. Mycosis fungoides involving the oral mucosa in a child. Clin Exp Dermatol. 2003;28(5):499–501.CrossRefPubMed

Bassuner J, Miranda RN, Emge DA, DiCicco BA, Lewis DJ, Duvic M. Mycosis fungoides of the oral cavity: fungating tumor successfully treated with electron beam radiation and maintenance bexarotene. Case Rep Dermatol Med. 2016;2016:5857935. doi:10.1155/2016/5857935.PubMedPubMedCentralCrossRef

de la Fuente EG, Rodriguez-Peralto JL, Ortiz PL, Barrientos N, Vanaclocha F, Iglesias L. Oral involvement in mycosis fungoides: report of two cases and a literature review. Acta Derm Venereol. 2000;80(4):299–301.CrossRefPubMed

10.

May SA, Jones D, Medeiros LJ, Duvic M, Prieto VG, Lazar AJ. Oral-cutaneous CD4-positive T-cell lymphoma: a study of two patients. Am J Dermatopathol. 2007;29(1):62–7. doi:10.1097/01.dad.0000246949.49071.17.CrossRefPubMed

11.

Damm DD, White DK, Cibull ML, Drummond JF, Cramer JR. Mycosis fungoides: initial diagnosis via palatal biopsy with discussion of diagnostic advantages of plastic embedding. Oral Surg Oral Med Oral Pathol. 1984;58(4):413–9.CrossRefPubMed

12.

Harman M, Akdeniz S, Arslan A, Koyoglu S. Mycosis fungoides with involvement of the oral cavity. J Eur Acad Dermatol Venereol. 1998;10(3):253–6.CrossRefPubMed

13.

Barnett ML, Cole RJ. Mycosis fungoides with multiple oral mucosal lesions. a case report. J Periodontol. 1985;56(11):690–3. doi:10.1902/jop.1985.56.11.690.CrossRefPubMed

14.

Chua MS, Veness MJ. Mycosis fungoides involving the oral cavity. Australas Radiol. 2002;46(3):336–9.CrossRefPubMed

15.

Sirois DA, Miller AS, Harwick RD, Vonderheid EC. Oral manifestations of cutaneous T-cell lymphoma. A report of eight cases. Oral Surg Oral Med Oral Pathol. 1993;75(6):700–5.CrossRefPubMed

16.

Cheng YS, Gould A, Kurago Z, Fantasia J, Muller S. Diagnosis of oral lichen planus: a position paper of the American Academy of Oral and Maxillofacial Pathology. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;122(3):332–54. doi:10.1016/j.oooo.2016.05.004.CrossRefPubMed

17.

Hata T, Aikoh T, Hirokawa M, Hosoda M. Mycosis fungoides with involvement of the oral mucosa. Int J Oral Maxillofac Surg. 1998;27(2):127–8.CrossRefPubMed

18.

Benner MF, Jansen PM, Vermeer MH, Willemze R. Prognostic factors in transformed mycosis fungoides: a retrospective analysis of 100 cases. Blood. 2012;119(7):1643–9. doi:10.1182/blood-2011-08-376319.CrossRefPubMed

19.

Salhany KE, Cousar JB, Greer JP, Casey TT, Fields JP, Collins RD. Transformation of cutaneous T cell lymphoma to large cell lymphoma. A clinicopathologic and immunologic study. Am J Pathol. 1988;132(2):265–77.PubMedPubMedCentral

20.

Ficarra G, Prignano F, Romagnoli P. Traumatic eosinophilic granuloma of the oral mucosa: a CD30+(Ki-1) lymphoproliferative disorder? Oral Oncol. 1997;33(5):375–9.CrossRefPubMed

21.

Al Hothali GI. Review of the treatment of mycosis fungoides and Sezary syndrome: a stage-based approach. Int J Health Sci. 2013;7(2):220–39.CrossRef

22.

Postorino M, Pupo L, Provenzano I, Del Principe MI, Buccisano F, Franceschini L, et al. A case of oral mycosis fungoides successfully treated by combination of alemtuzumab and chemotherapy. Ann Hematol. 2016;95(1):153–4. doi:10.1007/s00277-015-2503-z.CrossRefPubMed

23.

Bittencourt AL, Oliveira PD, Carvalho-Andrade A, Araujo I. Correlations between clinical and pathological features in 17 cases of mycosis fungoides before and after transformation. Int J Dermatol. 2015;54(9):e327–e31. doi:10.1111/ijd.12875.CrossRefPubMed

24.

Kunishige J, Harriott Fisher A, Holsinger F, Feasel A, Duvic M. Mycosis fungoides of the tongue. Internet J Dermatol. 2006;5:1–4.

Titel: Large Cell Transformation of Oral Mycosis Fungoides
verfasst von: Ahmed S. Sultan
Behzad Mostoufi
John C. Papadimitriou
Rima Koka
John Basile
Rania H. Younis
Publikationsdatum: 24.07.2017
Verlag: Springer US
Erschienen in: Head and Neck Pathology / Ausgabe 2/2018
Elektronische ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-017-0840-z

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Large Cell Transformation of Oral Mycosis Fungoides

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2018

Hybrid Central Odontogenic Fibroma with Giant Cell Granuloma like Lesion: A Report of Three Additional Cases and Review of the Literature

Beyond the Percentages of PD-L1-Positive Tumor Cells: Induced Versus Constitutive PD-L1 Expression in Primary and Metastatic Head and Neck Squamous Cell Carcinoma

In Reply: Colonic-Type Adenocarcinoma of the Tongue and Oral Cavity (CATOC)

Cervical Chondrocutaneous Branchial Remnants

Sinonasal Tract Alveolar Rhabdomyosarcoma in Adults: A Clinicopathologic and Immunophenotypic Study of Fifty-Two Cases with Emphasis on Epithelial Immunoreactivity

Colonic-type Adenocarcinoma of the Tongue and Oral Cavity (CATOC)

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie