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01.12.2015 | Original Article

Age-related changes in FDG brain uptake are more accurately assessed when applying an adaptive template to the SPM method of voxel-based quantitative analysis

verfasst von: Axel Van Der Gucht, Antoine Verger, Eric Guedj, Grégoire Malandain, Gabriela Hossu, Yalcin Yagdigul, Véronique Roch, Sylvain Poussier, Louis Maillard, Gilles Karcher, Pierre-Yves Marie

Erschienen in: Annals of Nuclear Medicine | Ausgabe 10/2015

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Abstract

Introduction

The impact of age is crucial and must be taken into account when applying a voxel-based quantitative analysis on brain images from [¹⁸F]-fluorodeoxyglucose Positron Emission Tomography (FDG-PET). This study aimed to determine whether age-related changes in brain FDG-PET images are more accurately assessed when the conventional statistical parametric mapping (SPM) normalization method is used with an adaptive template, obtained from analysed PET images using a Block-Matching (BM) algorithm to fit with the characteristics of these images.

Methods

Age-related changes in FDG-PET images were computed with linear models in 84 neurologically healthy subjects (35 women, 19 to 82-year-old), and compared between results provided by the SPM normalization algorithm applied on its dedicated conventional template or on the adaptive BM template. A threshold P value of 0.05 was used together with a family-wise error correction.

Results

The age-related changes in FDG-PET images were much more apparent when computed with the adaptive template than with the conventional template as evidenced by: (1) stronger correlation coefficients with age for the overall frontal and temporal uptake values (respective R ² values of 0.20 and 0.07) and (2) larger extents of involved areas (13 and 5 % of whole brain template volume, respectively), leading to reveal several age-dependent areas (especially in dorsolateral prefrontal, inferior temporal/fusiform and primary somatosensory cortices).

Conclusion

Age-related changes in brain FDG uptake may be more accurately determined when applying the SPM method of voxel-based quantitative analysis on a template that best fits the characteristics of the analysed TEP images.

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Titel: Age-related changes in FDG brain uptake are more accurately assessed when applying an adaptive template to the SPM method of voxel-based quantitative analysis
verfasst von: Axel Van Der Gucht
Antoine Verger
Eric Guedj
Grégoire Malandain
Gabriela Hossu
Yalcin Yagdigul
Véronique Roch
Sylvain Poussier
Louis Maillard
Gilles Karcher
Pierre-Yves Marie
Publikationsdatum: 01.12.2015
Verlag: Springer Japan
Erschienen in: Annals of Nuclear Medicine / Ausgabe 10/2015
Print ISSN: 0914-7187
Elektronische ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-015-1022-2

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Age-related changes in FDG brain uptake are more accurately assessed when applying an adaptive template to the SPM method of voxel-based quantitative analysis

Abstract

Introduction

Methods

Results

Conclusion

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Introduction

Methods

Results

Conclusion

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