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Neuroscience Bulletin

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01.12.2019 | Review

High-Voltage-Activated Calcium Channel in the Afferent Pain Pathway: An Important Target of Pain Therapies

verfasst von: Qi Li, Jian Lu, Xiaoxin Zhou, Xuemei Chen, Diansan Su, Xiyao Gu, Weifeng Yu

Erschienen in: Neuroscience Bulletin | Ausgabe 6/2019

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Abstract

High-voltage-activated (HVA) Ca²⁺ channels are widely expressed in the nervous system. They play an important role in pain conduction by participating in various physiological processes such as synaptic transmission, changes in synaptic plasticity, and neuronal excitability. Available evidence suggests that the HVA channel is an important therapeutic target for pain management. In this review, we summarize the changes in different subtypes of HVA channel during pain and present the currently available evidence from the clinical application of HVA channel blockers. We also review novel drugs in various phases of development. Moreover, we discuss the future prospects of HVA channel blockers in order to promote “bench-to-bedside” translation.

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Titel: High-Voltage-Activated Calcium Channel in the Afferent Pain Pathway: An Important Target of Pain Therapies
verfasst von: Qi Li
Jian Lu
Xiaoxin Zhou
Xuemei Chen
Diansan Su
Xiyao Gu
Weifeng Yu
Publikationsdatum: 01.12.2019
Verlag: Springer Singapore
Erschienen in: Neuroscience Bulletin / Ausgabe 6/2019
Print ISSN: 1673-7067
Elektronische ISSN: 1995-8218
DOI: https://doi.org/10.1007/s12264-019-00378-5

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