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Journal of Cardiovascular Translational Research
Erschienen in: Journal of Cardiovascular Translational Research 3/2022

17.09.2021 | Review

Physical Exercise Protects Against Endothelial Dysfunction in Cardiovascular and Metabolic Diseases

verfasst von: Juan Gao, Xue Pan, Guoping Li, Emeli Chatterjee, Junjie Xiao

Erschienen in: Journal of Cardiovascular Translational Research | Ausgabe 3/2022

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Abstract

Increasing evidence shows that endothelial cells play critical roles in maintaining vascular homeostasis, regulating vascular tone, inhibiting inflammatory response, suppressing lipid leakage, and preventing thrombosis. The damage or injury of endothelial cells induced by physical, chemical, and biological risk factors is a leading contributor to the development of mortal cardiovascular and cerebrovascular diseases. However, the underlying mechanism of endothelial injury remains to be elucidated. Notably, no drugs effectively targeting and mending injured vascular endothelial cells have been approved for clinical practice. There is an urgent need to understand pathways important for repairing injured vasculature that can be targeted with novel therapies. Exercise training-induced protection to endothelial injury has been well documented in clinical trials, and the underlying mechanism has been explored in animal models. This review mainly summarizes the protective effects of exercise on vascular endothelium and the recently identified potential therapeutic targets for endothelial dysfunction.
Literatur
1.
Augustin, H. G., Kozian, D. H., & Johnson, R. C. (1994). Differentiation of endothelial cells: Analysis of the constitutive and activated endothelial cell phenotypes. BioEssays: news and reviews in molecular, cellular and developmental biology, 16, 901–906.CrossRef
2.
Loukas, M., Clarke, P., Tubbs, R. S., Kapos, T., & Trotz, M. (2008). The His family and their contributions to cardiology. International Journal of Cardiology, 123, 75–78.PubMedCrossRef
3.
Luscher, T. F., & Barton, M. (1997). Biology of the endothelium. Clinical cardiology, 20, II-3–10.CrossRef
4.
5.
Godo, S., & Shimokawa, H. (2017). Endothelial functions. Arteriosclerosis, Thrombosis, and Vascular Biology, 37, e108–e114.PubMedCrossRef
6.
Michiels, C. (2003). Endothelial cell functions. Journal of Cellular Physiology, 196, 430–443.PubMedCrossRef
7.
Mombouli, J. V., & Vanhoutte, P. M. (1999). Endothelial dysfunction: From physiology to therapy. Journal of Molecular and Cellular Cardiology, 31, 61–74.PubMedCrossRef
8.
Davignon, J., & Ganz, P. (2004). Role of endothelial dysfunction in atherosclerosis. Circulation, 109, III27-32.PubMed
9.
10.
Palmer, R. M., Ferrige, A. G., & Moncada, S. (1987). Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature, 327, 524–526.PubMedCrossRef
11.
Emoto, N., Vignon-Zellweger, N., Lopes, R. A., Cacioppo, J., Desbiens, L., Kamato, D., Leurgans, T., Moorhouse, R., Straube, J., Wurm, R., et al. (2014). 25 years of endothelin research: The next generation. Life sciences, 118, 77–86.PubMedCrossRef
12.
Galley, H. F., & Webster, N. R. (2004). Physiology of the endothelium. British Journal of Anaesth, 93, 105–113.CrossRef
13.
14.
Booth, F. W., Roberts, C. K., & Laye, M. J. (2012). Lack of exercise is a major cause of chronic diseases. Comprehensive Physiology, 2, 1143–1211.PubMedPubMedCentralCrossRef
15.
16.
Anderson, T. J., Uehata, A., Gerhard, M. D., Meredith, I. T., Knab, S., Delagrange, D., Lieberman, E. H., Ganz, P., Creager, M. A., Yeung, A. C., et al. (1995). Close relation of endothelial function in the human coronary and peripheral circulations. Journal of the American College of Cardiology, 26, 1235–1241.PubMedCrossRef
17.
Scicchitano, P., Cortese, F., Gesualdo, M., De Palo, M., Massari, F., Giordano, P., & Ciccone, M. M. (2019). The role of endothelial dysfunction and oxidative stress in cerebrovascular diseases. Free Radical Research, 53, 579–595.PubMedCrossRef
18.
Karoli, N. A., & Rebrov, A. P. (2019). Endothelial dysfunction in patients with chronic obstructive pulmonary disease in combination with coronary heart disease. Terapevticheskii Arkhiv, 91, 22–26.PubMedCrossRef
19.
Brutsaert, D. L., Fransen, P., Andries, L. J., De Keulenaer, G. W., & Sys, S. U. (1998). Cardiac endothelium and myocardial function. Cardiovascular Research, 38, 281–290.PubMedCrossRef
20.
Smiljic, S. (2017). The clinical significance of endocardial endothelial dysfunction. Medicina (Kaunas, Lithuania), 53, 295–302.CrossRef
21.
Tang, D. H., Bai, S., Li, X. L., Yao, M., Gong, Y. J., Hou, Y. J., Li, J., & Yang, D. S. (2019). Improvement of microvascular endothelial dysfunction induced by exercise and diet is associated with microRNA-126 in obese adolescents. Microvascular Research, 123, 86–91.CrossRef
22.
Cecchi, F., Sgalambro, A., Baldi, M., Sotgia, B., Antoniucci, D., Camici, P. G., Sciagra, R., & Olivotto, I. (2009). Microvascular dysfunction, myocardial ischemia, and progression to heart failure in patients with hypertrophic cardiomyopathy. Journal of Cardiovascular Translational Research, 2, 452–461.PubMedCrossRef
23.
Brutsaert, D. L. (2003). Cardiac endothelial-myocardial signaling: Its role in cardiac growth, contractile performance, and rhythmicity. Physiological Reviews, 83, 59–115.PubMedCrossRef
24.
Qiu, J., Li, J., & He, T. C. (2011). Endothelial cell damage induces a blood-alveolus barrier breakdown in the development of radiation-induced lung injury. Asia-Pacific Journal of Clinical Oncology, 7, 392–398.PubMedCrossRef
25.
Good, R. B., Gilbane, A. J., Trinder, S. L., Denton, C. P., Coghlan, G., Abraham, D. J., & Holmes, A. M. (2015). Endothelial to mesenchymal transition contributes to endothelial dysfunction in pulmonary arterial hypertension. American Journal of Pathology, 185, 1850–1858.PubMedCrossRef
26.
Graves, S. I., & Baker, D. J. (2020). Implicating endothelial cell senescence to dysfunction in the ageing and diseased brain. Basic & Clinical Pharmacology & Toxicology, 127, 102–110.CrossRef
27.
Wardlaw, J. M., Smith, C., & Dichgans, M. (2019). Small vessel disease: Mechanisms and clinical implications. Lancet Neurology, 18, 684–696.PubMedCrossRef
28.
Poggesi, A., Pasi, M., Pescini, F., Pantoni, L., & Inzitari, D. (2016). Circulating biologic markers of endothelial dysfunction in cerebral small vessel disease: A review. Journal of Cerebral Blood Flow and Metabolism, 36, 72–94.PubMedPubMedCentralCrossRef
29.
Jourde-Chiche, N., Fakhouri, F., Dou, L., Bellien, J., Burtey, S., Frimat, M., Jarrot, P. A., Kaplanski, G., Le Quintrec, M., Pernin, V., et al. (2019). Endothelium structure and function in kidney health and disease. Nature Reviews Nephrology, 15, 87–108.PubMedCrossRef
30.
Jankauskas, S. S., Andrianova, N. V., Alieva, I. B., Prusov, A. N., Matsievsky, D. D., Zorova, L. D., Pevzner, I. B., Savchenko, E. S., Pirogov, Y. A., Silachev, D. N., et al. (2016). Dysfunction of kidney endothelium after ischemia/reperfusion and its prevention by mitochondria-targeted antioxidant. Biochemistry (Moscow), 81, 1538–1548.CrossRef
31.
Malyszko, J. (2010). Mechanism of endothelial dysfunction in chronic kidney disease. Clinica Chimica Acta, 411, 1412–1420.CrossRef
32.
Hammoutene, A., & Rautou, P. E. (2019). Role of liver sinusoidal endothelial cells in non-alcoholic fatty liver disease. Journal of Hepatology, 70, 1278–1291.PubMedCrossRef
33.
Rockey, D. C. (2015). Endothelial dysfunction in advanced liver disease. American Journal of the Medical Sciences, 349, 6–16.PubMedCrossRef
34.
Poisson, J., Lemoinne, S., Boulanger, C., Durand, F., Moreau, R., Valla, D., & Rautou, P. E. (2017). Liver sinusoidal endothelial cells: Physiology and role in liver diseases. Journal of Hepatology, 66, 212–227.PubMedCrossRef
35.
Bernardo, B. C., Ooi, J. Y. Y., Weeks, K. L., Patterson, N. L., & McMullen, J. R. (2018). Understanding key mechanisms of exercise-induced cardiac protection to mitigate disease: Current knowledge and emerging concepts. Physiological Reviews, 98, 419–475.PubMedCrossRef
36.
Rocha, B., Rodrigues, A. R., Tomada, I., Martins, M. J., Guimaraes, J. T., Gouveia, A. M., Almeida, H., & Neves, D. (2018). Energy restriction, exercise and atorvastatin treatment improve endothelial dysfunction and inhibit miRNA-155 in the erectile tissue of the aged rat. Nutrition & Metabolism. https://​doi.​org/​10.​1186/​s12986-018-0265-z 
37.
La Favor, J. D., Anderson, E. J., Dawkins, J. T., Hickner, R. C., & Wingard, C. J. (2013). Exercise prevents Western diet-associated erectile dysfunction and coronary artery endothelial dysfunction: Response to acute apocynin and sepiapterin treatment. American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 305, R423–R434.PubMedPubMedCentralCrossRef
38.
Lee, S., Park, Y., & Zhang, C. (2011). Exercise training prevents coronary endothelial dysfunction in type 2 diabetic mice. American Journal of Biomedical Sciences, 3, 241–252.PubMedPubMedCentralCrossRef
39.
40.
Wong, B. W., Marsch, E., Treps, L., Baes, M., & Carmeliet, P. (2017). Endothelial cell metabolism in health and disease: Impact of hypoxia. EMBO Journal, 36, 2187–2203.PubMedPubMedCentralCrossRef
41.
Eelen, G., de Zeeuw, P., Simons, M., & Carmeliet, P. (2015). Endothelial cell metabolism in normal and diseased vasculature. Circulation Research, 116, 1231–1244.PubMedPubMedCentralCrossRef
42.
Cannon, M. S. (1984). A histochemical study of the metabolism of rat renal arteries and arterioles. Angiology, 35, 129–136.PubMedCrossRef
43.
Cook, B. H., Granger, H. J., & Taylor, A. E. (1977). Metabolism of coronary arteries and arterioles: A histochemical study. Microvascular Research, 14, 145–159.PubMedCrossRef
44.
Byts' Iu, V., and Ataman, A. V. (1989). Energy metabolism in arteries and veins in modelling epinephrine damage to the vascular wall. Patol Fiziol Eksp Ter, 63–66.
45.
Sarelius, I. H., Cohen, K. D., & Murrant, C. L. (2000). Role for capillaries in coupling blood flow with metabolism. Clinical and Experimental Pharmacology and Physiology, 27, 826–829.PubMedCrossRef
46.
Menghini, R., Casagrande, V., Iuliani, G., Rizza, S., Mavilio, M., Cardellini, M., & Federici, M. (2020). Metabolic aspects of cardiovascular diseases: Is FoxO1 a player or a target? International Journal of Biochemistry and Cell Biology, 118, 105659.PubMedCrossRef
47.
Wilhelm, K., Happel, K., Eelen, G., Schoors, S., Oellerich, M. F., Lim, R., Zimmermann, B., Aspalter, I. M., Franco, C. A., Boettger, T., et al. (2016). FOXO1 couples metabolic activity and growth state in the vascular endothelium. Nature, 529, 216–220.PubMedPubMedCentralCrossRef
48.
Hariharan, N., Maejima, Y., Nakae, J., Paik, J., Depinho, R. A., & Sadoshima, J. (2010). Deacetylation of FoxO by Sirt1 plays an essential role in mediating starvation-induced autophagy in cardiac myocytes. Circulation Research, 107, 1470–1482.PubMedPubMedCentralCrossRef
49.
Rudnicki, M., Abdifarkosh, G., Nwadozi, E., Ramos, S. V., Makki, A., Sepa-Kishi, D. M., Ceddia, R. B., Perry, C. G., Roudier, E., & Haas, T. L. (2018). Endothelial-specific FoxO1 depletion prevents obesity-related disorders by increasing vascular metabolism and growth. elife. https://​doi.​org/​10.​7554/​eLife.​39780.
50.
Celermajer, D. S., Sorensen, K. E., Gooch, V. M., Spiegelhalter, D. J., Miller, O. I., Sullivan, I. D., Lloyd, J. K., & Deanfield, J. E. (1992). Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet, 340, 1111–1115.PubMedCrossRef
51.
Takase, B., Uehata, A., Fujioka, T., Kondo, T., Nishioka, T., Isojima, K., Satomura, K., Ohsuzu, F., & Kurita, A. (2001). Endothelial dysfunction and decreased exercise tolerance in interferon-alpha therapy in chronic hepatitis C: Relation between exercise hyperemia and endothelial function. Clinical Cardiology, 24, 286–290.PubMedCrossRef
52.
Huang, P. H., Leu, H. B., Chen, J. W., Cheng, C. M., Huang, C. Y., Tuan, T. C., Ding, P. Y. A., & Lin, S. J. (2004). Usefulness of attenuated heart rate recovery immediately after exercise to predict endothelial dysfunction in patients with suspected coronary artery disease. American Journal of Cardiology, 93, 10–13.PubMedCrossRef
53.
Kuvin, J. T., Patel, A. R., Sliney, K. A., Pandian, N. G., Sheffy, J., Schnall, R. P., Karas, R. H., & Udelson, J. E. (2003). Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude. American Heart Journal, 146, 168–174.PubMedCrossRef
54.
Boos, C. J., Balakrishnan, B., & Lip, G. Y. H. (2008). The effects of exercise stress testing on soluble E-selectin, von Willebrand factor, and circulating endothelial cells as indices of endothelial damage/dysfunction. Annals of Medicine, 40, 66–73.PubMedCrossRef
55.
Boos, C. J., Lip, G. Y., & Blann, A. D. (2006). Circulating endothelial cells in cardiovascular disease. Journal of the American College of Cardiology, 48, 1538–1547.PubMedCrossRef
56.
Wang, L., Wang, J., Cretoiu, D., Li, G., & Xiao, J. (2020). Exercise-mediated regulation of autophagy in the cardiovascular system. Journal of Sport and Health Science, 9, 203–210.PubMedCrossRef
57.
Luan, X., Tian, X. Y., Zhang, H. X., Huang, R., Li, N., Chen, P. J., & Wang, R. (2019). Exercise as a prescription for patients with various diseases. Journal of Sport and Health Science, 8, 422–441.PubMedPubMedCentralCrossRef
58.
59.
De Keulenaer, G. W., Segers, V. F. M., Zannad, F., & Brutsaert, D. L. (2017). The future of pleiotropic therapy in heart failure. Lessons from the benefits of exercise training on endothelial function. European Journal of Heart Failure, 19, 603–614.PubMedCrossRef
60.
Wang, R. W., Tian, H. L., Guo, D. D., Tian, Q. Q., Yao, T., & Kong, X. X. (2020). Impacts of exercise intervention on various diseases in rats. Journal of Sport and Health Science, 9, 211–227.PubMedCrossRef
61.
Downey, R. M., Liao, P. Z., Millson, E. C., Quyyumi, A. A., Sher, S., & Park, J. (2017). Endothelial dysfunction correlates with exaggerated exercise pressor response during whole body maximal exercise in chronic kidney disease. American Journal of Physiology-Renal Physiology, 312, F917–F924.PubMedPubMedCentralCrossRef
62.
La Favor, J. D., Dubis, G. S., Yan, H., White, J. D., Nelson, M. A., Anderson, E. J., & Hickner, R. C. (2016). Microvascular endothelial dysfunction in sedentary, obese humans is mediated by NADPH oxidase: Influence of exercise training. Arteriosclerosis, Thrombosis, and Vascular Biology, 36, 2412–2420.PubMedPubMedCentralCrossRef
63.
Schuler, G., Adams, V., & Goto, Y. (2013). Role of exercise in the prevention of cardiovascular disease: Results, mechanisms, and new perspectives. European Heart Journal, 34, 1790–1799.PubMedCrossRef
64.
65.
Vona, M., Codeluppi, G. M., Iannino, T., Ferrari, E., Bogousslavsky, J., & von Segesser, L. K. (2009). Effects of different types of exercise training followed by detraining on endothelium-dependent dilation in patients with recent myocardial infarction. Circulation, 119, 1601–1608.PubMedCrossRef
66.
Gevaert, A. B., Beckers, P. J., Van Craenenbroeck, A. H., Lemmens, K., Van De Heyning, C. M., Heidbuchel, H., Vrints, C. J., & Van Craenenbroeck, E. M. (2019). Endothelial dysfunction and cellular repair in heart failure with preserved ejection fraction: Response to a single maximal exercise bout. European Journal of Heart Failure, 21, 125–127.PubMedCrossRef
67.
Djohan, A. H., Sia, C. H., Lee, P. S., & Poh, K. K. (2018). Endothelial progenitor cells in heart failure: An authentic expectation for potential future use and a lack of universal definition. Journal of Cardiovascular Translational Research, 11, 393–402.PubMedCrossRef
68.
Asahara, T., Murohara, T., Sullivan, A., Silver, M., van der Zee, R., Li, T., Witzenbichler, B., Schatteman, G., & Isner, J. M. (1997). Isolation of putative progenitor endothelial cells for angiogenesis. Science, 275, 964–967.PubMedCrossRef
69.
Kaushik, K., & Das, A. (2019). Endothelial progenitor cell therapy for chronic wound tissue regeneration. Cytotherapy, 21, 1137–1150.PubMedCrossRef
70.
Qiao, J., Qi, K., Chu, P., Mi, H., Yang, N., Yao, H., Xia, Y., Li, Z., Xu, K., & Zeng, L. (2015). Infusion of endothelial progenitor cells ameliorates liver injury in mice after haematopoietic stem cell transplantation. Liver International, 35, 2611–2620.PubMedCrossRef
71.
Zhao, Q., Liu, Z., Wang, Z., Yang, C., Liu, J., & Lu, J. (2007). Effect of prepro-calcitonin gene-related peptide-expressing endothelial progenitor cells on pulmonary hypertension. Annals of Thoracic Surgery, 84, 544–552.PubMedCrossRef
72.
Ming, G. F., Tang, Y. J., Hu, K., Chen, Y., Huang, W. H., & Xiao, J. (2016). Visfatin attenuates the ox-LDL-induced senescence of endothelial progenitor cells by upregulating SIRT1 expression through the PI3K/Akt/ERK pathway. International Journal of Molecular Medicine, 38, 643–649.PubMedCrossRef
73.
Subramaniyam, V., Waller, E. K., Murrow, J. R., Manatunga, A., Lonial, S., Kasirajan, K., Sutcliffe, D., Harris, W., Taylor, W. R., Alexander, R. W., et al. (2009). Bone marrow mobilization with granulocyte macrophage colony-stimulating factor improves endothelial dysfunction and exercise capacity in patients with peripheral arterial disease. American Heart Journal, 158, 53–60.
74.
Recchioni, R., Marcheselli, F., Antonicelli, R., Lazzarini, R., Mensa, E., Testa, R., Procopio, A. D., & Olivieri, F. (2016). Physical activity and progenitor cell-mediated endothelial repair in chronic heart failure: Is there a role for epigenetics? Mechanisms of Ageing and Development, 159, 71–80.PubMedCrossRef
75.
Sandri, M., Adams, V., Gielen, S., Linke, A., Lenk, K., Krankel, N., Lenz, D., Erbs, S., Scheinert, D., Mohr, F. W., et al. (2005). Effects of exercise and ischemia on mobilization and functional activation of blood-derived progenitor cells in patients with ischemic syndromes: Results of 3 randomized studies. Circulation, 111, 3391–3399.PubMedCrossRef
76.
Steiner, S., Niessner, A., Ziegler, S., Richter, B., Seidinger, D., Pleiner, J., Penka, M., Wolzt, M., Huber, K., Wojta, J., et al. (2005). Endurance training increases the number of endothelial progenitor cells in patients with cardiovascular risk and coronary artery disease. Atherosclerosis, 181, 305–310.PubMedCrossRef
77.
Schlager, O., Giurgea, A., Schuhfried, O., Seidinger, D., Hammer, A., Groger, M., Fialka-Moser, V., Gschwandtner, M., Koppensteiner, R., & Steiner, S. (2011). Exercise training increases endothelial progenitor cells and decreases asymmetric dimethylarginine in peripheral arterial disease: A randomized controlled trial. Atherosclerosis, 217, 240–248.PubMedCrossRef
78.
Brehm, M., Picard, F., Ebner, P., Turan, G., Bolke, E., Kostering, M., Schuller, P., Fleissner, T., Ilousis, D., Augusta, K., et al. (2009). Effects of exercise training on mobilization and functional activity of blood-derived progenitor cells in patients with acute myocardial infarction. European Journal of Medical Research, 14, 393–405.PubMedPubMedCentralCrossRef
79.
80.
Hambrecht, R., Wolf, A., Gielen, S., Linke, A., Hofer, J., Erbs, S., Schoene, N., & Schuler, G. (2000). Effect of exercise on coronary endothelial function in patients with coronary artery disease. New England Journal of Medicine, 342, 454–460.PubMedCrossRef
81.
Luk, T. H., Dai, Y. L., Siu, C. W., Yiu, K. H., Chan, H. T., Lee, S. W., Li, S. W., Fong, B., Wong, W. K., Tam, S., et al. (2012). Effect of exercise training on vascular endothelial function in patients with stable coronary artery disease: A randomized controlled trial. European Journal of Preventive Cardiology, 19, 830–839.PubMedCrossRef
82.
Edwards, D. G., Schofield, R. S., Lennon, S. L., Pierce, G. L., Nichols, W. W., & Braith, R. W. (2004). Effect of exercise training on endothelial function in men with coronary artery disease. American Journal of Cardiology, 93, 617–620.PubMedCrossRef
83.
Gokce, N., Vita, J. A., Bader, D. S., Sherman, D. L., Hunter, L. M., Holbrook, M., O’Malley, C., Keaney, J. F., Jr., & Balady, G. J. (2002). Effect of exercise on upper and lower extremity endothelial function in patients with coronary artery disease. American Journal of Cardiology, 90, 124–127.PubMedCrossRef
84.
Adams, V., Linke, A., Krankel, N., Erbs, S., Gielen, S., Mobius-Winkler, S., Gummert, J. F., Mohr, F. W., Schuler, G., & Hambrecht, R. (2005). Impact of regular physical activity on the NAD(P)H oxidase and angiotensin receptor system in patients with coronary artery disease. Circulation, 111, 555–562.PubMedCrossRef
85.
Hambrecht, R., Adams, V., Erbs, S., Linke, A., Krankel, N., Shu, Y., Baither, Y., Gielen, S., Thiele, H., Gummert, J. F., et al. (2003). Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase. Circulation, 107, 3152–3158.PubMedCrossRef
86.
Hosokawa, S., Hiasa, Y., Takahashi, T., & Itoh, S. (2003). Effect of regular exercise on coronary endothelial function in patients with recent myocardial infarction. Circulation Journal, 67, 221–224.PubMedCrossRef
87.
Belardinelli, R., Mucaj, A., Lacalaprice, F., Solenghi, M., Seddaiu, G., Principi, F., Tiano, L., & Littarru, G. P. (2006). Coenzyme Q10 and exercise training in chronic heart failure. European Heart Journal, 27, 2675–2681.PubMedCrossRef
88.
Adamopoulos, S., Parissis, J., Kroupis, C., Georgiadis, M., Karatzas, D., Karavolias, G., Koniavitou, K., Coats, A. J., & Kremastinos, D. T. (2001). Physical training reduces peripheral markers of inflammation in patients with chronic heart failure. European Heart Journal, 22, 791–797.PubMedCrossRef
89.
Mancini, D. M., Walter, G., Reichek, N., Lenkinski, R., McCully, K. K., Mullen, J. L., & Wilson, J. R. (1992). Contribution of skeletal muscle atrophy to exercise intolerance and altered muscle metabolism in heart failure. Circulation, 85, 1364–1373.PubMedCrossRef
90.
Hwang, M. H., & Kim, S. (2014). Type 2 diabetes: Endothelial dysfunction and exercise. Journal of Exercise Nutrition & Biochemistry, 18, 239–247.CrossRef
91.
Liese, A. D., Ma, X. G., Maahs, D. M., & Trilk, J. L. (2013). Physical activity, sedentary behaviors, physical fitness, and their relation to health outcomes in youth with type 1 and type 2 diabetes: A review of the epidemiologic literature. Journal of Sport and Health Science, 2, 21–38.CrossRef
92.
Leung, F. P., Yung, L. M., Laher, I., Yao, X., Chen, Z. Y., & Huang, Y. (2008). Exercise, vascular wall and cardiovascular diseases: An update (Part 1). Sports Medicine, 38, 1009–1024.PubMedCrossRef
93.
Yung, L. M., Laher, I., Yao, X., Chen, Z. Y., Huang, Y., & Leung, F. P. (2009). Exercise, vascular wall and cardiovascular diseases: An update (part 2). Sports Medicine, 39, 45–63.PubMedCrossRef
94.
Sixt, S., Beer, S., Bluher, M., Korff, N., Peschel, T., Sonnabend, M., Teupser, D., Thiery, J., Adams, V., Schuler, G., et al. (2010). Long- but not short-term multifactorial intervention with focus on exercise training improves coronary endothelial dysfunction in diabetes mellitus type 2 and coronary artery disease. European Heart Journal, 31, 112–119.PubMedCrossRef
95.
Cheang, W. S., Wong, W. T., Zhao, L., Xu, J., Wang, L., Lau, C. W., Chen, Z. Y., Ma, R. C., Xu, A., Wang, N., et al. (2017). PPARdelta is required for exercise to attenuate endoplasmic reticulum stress and endothelial dysfunction in diabetic mice. Diabetes, 66, 519–528.PubMedCrossRef
96.
Dong, Y., Zhang, M., Wang, S., Liang, B., Zhao, Z., Liu, C., Wu, M., Choi, H. C., Lyons, T. J., & Zou, M. H. (2010). Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivo. Diabetes, 59, 1386–1396.PubMedPubMedCentralCrossRef
97.
Davis, B. J., Xie, Z., Viollet, B., & Zou, M. H. (2006). Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase. Diabetes, 55, 496–505.PubMedCrossRef
98.
Enkhjargal, B., Godo, S., Sawada, A., Suvd, N., Saito, H., Noda, K., Satoh, K., & Shimokawa, H. (2014). Endothelial AMP-activated protein kinase regulates blood pressure and coronary flow responses through hyperpolarization mechanism in mice. Arteriosclerosis, Thrombosis, And Vascular Biology, 34, 1505–1513.PubMedCrossRef
99.
Cheang, W. S., Tian, X. Y., Wong, W. T., Lau, C. W., Lee, S. S., Chen, Z. Y., Yao, X., Wang, N., & Huang, Y. (2014). Metformin protects endothelial function in diet-induced obese mice by inhibition of endoplasmic reticulum stress through 5’ adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor delta pathway. Arteriosclerosis, Thrombosis, and Vascular Biology, 34, 830–836.PubMedCrossRef
100.
Lee, C. H., Olson, P., Hevener, A., Mehl, I., Chong, L. W., Olefsky, J. M., Gonzalez, F. J., Ham, J., Kang, H., Peters, J. M., et al. (2006). PPARdelta regulates glucose metabolism and insulin sensitivity. Proceedings of the National Academy of Sciences, 103, 3444–3449.CrossRef
101.
Narkar, V. A., Downes, M., Yu, R. T., Embler, E., Wang, Y. X., Banayo, E., Mihaylova, M. M., Nelson, M. C., Zou, Y., Juguilon, H., et al. (2008). AMPK and PPARdelta agonists are exercise mimetics. Cell, 134, 405–415.PubMedPubMedCentralCrossRef
102.
Lauer, T., Heiss, C., Balzer, J., Kehmeier, E., Mangold, S., Leyendecker, T., Rottler, J., Meyer, C., Merx, M. W., Kelm, M., et al. (2008). Age-dependent endothelial dysfunction is associated with failure to increase plasma nitrite in response to exercise. Basic Research in Cardiology, 103, 291–297.PubMedCrossRef
103.
104.
Park, J. H., Iemitsu, M., Maeda, S., Kitajima, A., Nosaka, T., & Omi, N. (2008). Voluntary running exercise attenuates the progression of endothelial dysfunction and arterial calcification in ovariectomized rats. Acta Physiologiae Plantarum, 193, 47–55.CrossRef
105.
Maeda, S., Tanabe, T., Miyauchi, T., Otsuki, T., Sugawara, J., Iemitsu, M., Kuno, S., Ajisaka, R., Yamaguchi, I., & Matsuda, M. (2003). Aerobic exercise training reduces plasma endothelin-1 concentration in older women. Journal of Applied Physiology, 95, 336–341.PubMedCrossRef
106.
Maeda, S., Tanabe, T., Otsuki, T., Sugawara, J., Iemitsu, M., Miyauchi, T., Kuno, S., Ajisaka, R., & Matsuda, M. (2004). Moderate regular exercise increases basal production of nitric oxide in elderly women. Hypertension Research: Official Journal of the Japanese Society of Hypertension, 27, 947–953.CrossRef
107.
Harvey, P. J., Picton, P. E., Su, W. S., Morris, B. L., Notarius, C. F., & Floras, J. S. (2005). Exercise as an alternative to oral estrogen for amelioration of endothelial dysfunction in postmenopausal women. American Heart Journal, 149, 291–297.PubMedCrossRef
108.
Xu, M., Duan, Y., & Xiao, J. (2019). Exercise improves the function of endothelial cells by MicroRNA. Journal of Cardiovascular Translational Research, 12, 391–393.PubMedCrossRef
109.
Wang, L., Lv, Y., Li, G., & Xiao, J. (2018). MicroRNAs in heart and circulation during physical exercise. Journal of Sport and Health Science, 7, 433–441.PubMedPubMedCentralCrossRef
110.
Zhang, J., Zhao, F., Yu, X., Lu, X., & Zheng, G. (2015). MicroRNA-155 modulates the proliferation of vascular smooth muscle cells by targeting endothelial nitric oxide synthase. International Journal of Molecular Sciences, 35, 1708–1714.
111.
Sun, H. X., Zeng, D. Y., Li, R. T., Pang, R. P., Yang, H., Hu, Y. L., Zhang, Q., Jiang, Y., Huang, L. Y., Tang, Y. B., et al. (2012). Essential role of microRNA-155 in regulating endothelium-dependent vasorelaxation by targeting endothelial nitric oxide synthase. Hypertension, 60, 1407–1414.PubMedCrossRef
112.
Tang, S. T., Wang, F., Shao, M., Wang, Y., & Zhu, H. Q. (2017). MicroRNA-126 suppresses inflammation in endothelial cells under hyperglycemic condition by targeting HMGB1. Vascular Pharmacology, 88, 48–55.PubMedCrossRef
113.
van Balkom, B. W., de Jong, O. G., Smits, M., Brummelman, J., den Ouden, K., de Bree, P. M., van Eijndhoven, M. A., Pegtel, D. M., Stoorvogel, W., Wurdinger, T., et al. (2013). Endothelial cells require miR-214 to secrete exosomes that suppress senescence and induce angiogenesis in human and mouse endothelial cells. Blood, 121, 3997–4006.PubMedCrossRef
114.
115.
Li, S., Xie, Y., Yang, B., Huang, S., Zhang, Y., Jia, Z., Ding, G., & Zhang, A. (2020). MicroRNA-214 targets COX-2 to antagonize indoxyl sulfate (IS)-induced endothelial cell apoptosis. Apoptosis, 25, 92–104.PubMedCrossRef
116.
Wang, S., Liao, J. W., Huang, J. H., Yin, H. G., Yang, W. Y., & Hu, M. (2018). miR-214 and miR-126 were associated with restoration of endothelial function in obesity after exercise and dietary intervention. Journal of Applied Biomedicine, 16, 34–39.CrossRef
117.
Chamorro-Jorganes, A., Araldi, E., Penalva, L. O., Sandhu, D., Fernandez-Hernando, C., & Suarez, Y. (2011). MicroRNA-16 and microRNA-424 regulate cell-autonomous angiogenic functions in endothelial cells via targeting vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1. Arteriosclerosis, Thrombosis, and Vascular Biology, 31, 2595–2606.PubMedPubMedCentralCrossRef
118.
Fernandes, T., Casaes, L., Soci, U., Silveira, A., Gomes, J., Barretti, D., Roque, F., & Oliveira, E. (2018). Exercise training restores the cardiac microrna-16 levels preventing microvascular rarefaction in obese Zucker rats. Obesity Facts, 11, 15–24.PubMedPubMedCentralCrossRef
119.
Cai, Y., Xie, K. L., Zheng, F., & Liu, S. X. (2018). Aerobic exercise prevents insulin resistance through the regulation of miR-492/resistin axis in aortic endothelium. Journal of Cardiovascular Translational Research, 11, 450–458.PubMedCrossRef
120.
121.
Olivieri, F., Lazzarini, R., Recchioni, R., Marcheselli, F., Rippo, M. R., Di Nuzzo, S., Albertini, M. C., Graciotti, L., Babini, L., Mariotti, S., et al. (2013). MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodelling. Age, 35, 1157–1172.PubMedCrossRef
122.
Cirilli, I., Silvestri, S., Marcheggiani, F., Olivieri, F., Galeazzi, R., Antonicelli, R., Recchioni, R., Marcheselli, F., Bacchetti, T., Tiano, L., et al. (2019). Three months monitored metabolic fitness modulates cardiovascular risk factors in diabetic patients. Diabetes & Metabolism Journal, 43, 893–897.CrossRef
123.
Kureishi, Y., Luo, Z., Shiojima, I., Bialik, A., Fulton, D., Lefer, D. J., Sessa, W. C., & Walsh, K. (2000). The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nature Medicine, 6, 1004–1010.PubMedPubMedCentralCrossRef
124.
Gong, X., Ma, Y., Ruan, Y., Fu, G., & Wu, S. (2014). Long-term atorvastatin improves age-related endothelial dysfunction by ameliorating oxidative stress and normalizing eNOS/iNOS imbalance in rat aorta. Experimental Gerontology, 52, 9–17.PubMedCrossRef
125.
Farquharson, C. A., Butler, R., Hill, A., Belch, J. J., & Struthers, A. D. (2002). Allopurinol improves endothelial dysfunction in chronic heart failure. Circulation, 106, 221–226.PubMedCrossRef
126.
Wyss, C. A., Koepfli, P., Namdar, M., Siegrist, P. T., Luscher, T. F., Camici, P. G., & Kaufmann, P. A. (2005). Tetrahydrobiopterin restores impaired coronary microvascular dysfunction in hypercholesterolaemia. European Journal of Nuclear Medicine and Molecular Imaging, 32, 84–91.PubMedCrossRef
127.
Melandri, G., Semprini, F., Cervi, V., Candiotti, N., Palazzini, E., Branzi, A., & Magnani, B. (1993). Benefit of adding low molecular weight heparin to the conventional treatment of stable angina pectoris. A double-blind, randomized, placebo-controlled trial. Circulation, 88, 2517–2523.PubMedCrossRef
128.
Rosengart, T. K., Lee, L. Y., Patel, S. R., Sanborn, T. A., Parikh, M., Bergman, G. W., Hachamovitch, R., Szulc, M., Kligfield, P. D., Okin, P. M., et al. (1999). Angiogenesis gene therapy: Phase I assessment of direct intramyocardial administration of an adenovirus vector expressing VEGF121 cDNA to individuals with clinically significant severe coronary artery disease. Circulation, 100, 468–474.PubMedCrossRef
129.
Rajagopalan, S., Shah, M., Luciano, A., Crystal, R., & Nabel, E. G. (2001). Adenovirus-mediated gene transfer of VEGF(121) improves lower-extremity endothelial function and flow reserve. Circulation, 104, 753–755.PubMedCrossRef
Metadaten
Titel
Physical Exercise Protects Against Endothelial Dysfunction in Cardiovascular and Metabolic Diseases
verfasst von
Juan Gao
Xue Pan
Guoping Li
Emeli Chatterjee
Junjie Xiao
Publikationsdatum
17.09.2021
Verlag
Springer US
Erschienen in
Journal of Cardiovascular Translational Research / Ausgabe 3/2022
Print ISSN: 1937-5387
Elektronische ISSN: 1937-5395
DOI
https://doi.org/10.1007/s12265-021-10171-3

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