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Journal of Nuclear Cardiology
Erschienen in: Journal of Nuclear Cardiology 4/2013

01.08.2013 | Original Article

Association of linear 18F-sodium fluoride accumulation in femoral arteries as a measure of diffuse calcification with cardiovascular risk factors: A PET/CT study

verfasst von: Tido Janssen, MD, Peter Bannas, MD, Jochen Herrmann, MD, Simon Veldhoen, MD, Jasmin D. Busch, MD, András Treszl, PhD, Silvia Münster, MD, Janos Mester, PhD, Thorsten Derlin, MD

Erschienen in: Journal of Nuclear Cardiology | Ausgabe 4/2013

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Abstract

Background

The aim of this study was to correlate linear 18F-sodium fluoride accumulation in the femoral arteries as a measure of diffuse mineral deposition in medial elastocalcinosis with cardiovascular risk factors (RFs) and calcified plaque burden (CPB).

Methods and Results

In this study, 409 patients were examined by 18F-sodium fluoride positron emission tomography/computed tomography (PET/CT). Tracer accumulation was analyzed both qualitatively and semiquantitatively by measuring the target-to-background ratio, and compared with cardiovascular RFs and CPB. Linear 18F-sodium fluoride accumulation was observed in 159 (38.9%) patients and correlated significantly with age (P < .0001), hypertension (P < .0001), hypercholesterolemia (P = .0003), diabetes (P = .0003), history of smoking (P = .0007), prior cardiovascular events (P = .03), and CPB (P < .0001). The prevalence of linear tracer uptake increased as the number of cardiovascular RFs increased (P < .0001).

Conclusions

Linear 18F-sodium fluoride uptake in the femoral arteries (1) provides a measure of diffuse mineral deposition, (2) demonstrates a highly significant correlation with cardiovascular RFs and CPB, and (3) is found to accumulate more frequently in patients with a high-risk profile for cardiovascular events. 18F-sodium fluoride PET/CT may become a unique tool for in vivo visualization and quantification of ongoing calcification in large arteries.
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Metadaten
Titel
Association of linear 18F-sodium fluoride accumulation in femoral arteries as a measure of diffuse calcification with cardiovascular risk factors: A PET/CT study
verfasst von
Tido Janssen, MD
Peter Bannas, MD
Jochen Herrmann, MD
Simon Veldhoen, MD
Jasmin D. Busch, MD
András Treszl, PhD
Silvia Münster, MD
Janos Mester, PhD
Thorsten Derlin, MD
Publikationsdatum
01.08.2013
Verlag
Springer US
Erschienen in
Journal of Nuclear Cardiology / Ausgabe 4/2013
Print ISSN: 1071-3581
Elektronische ISSN: 1532-6551
DOI
https://doi.org/10.1007/s12350-013-9680-8

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