nach oben

Erschienen in:

01.08.2019 | Brief Report

Comparison of maximal Rubidium-82 activities for myocardial blood flow quantification between digital and conventional PET systems

verfasst von: Joris D. van Dijk, MSc, PhD, Pieter L. Jager, MD, PhD, Jochen A. C. van Osch, MSc, Maryam Khodaverdi, PhD, Jorn A. van Dalen, PhD

Erschienen in: Journal of Nuclear Cardiology | Ausgabe 4/2019

Einloggen, um Zugang zu erhalten

Abstract

Background

PET-based myocardial blood flow (MBF) quantification can be inaccurate when using high tracer activities. Our aim was to derive the maximal Rubidium-82 activity for MBF assessment using a new digital PET system and compare the results with conventional analog systems.

Methods

1.8 GBq Rubidium-82 was injected into the cardiac insert of an anthropomorphic torso phantom. Data were acquired for 10 min using an Ingenuity TF (Philips Healthcare), Discovery 690 (D690, GE Healthcare), and digital PET prototype system (Philips Healthcare). The dynamic ranges, defined as the maximal measured activity in the reconstructed images deviating < 10% from the true present activity, were determined in all scans.

Results

The dynamic ranges were 312 MBq for Ingenuity TF, 650 MBq for D690, and 654 MBq for digital PET prototype.

Conclusions

The maximal Rb-82 activity for MBF assessment using digital PET prototype is higher than that for its analog counterpart (Ingenuity TF), but seems comparable to the D690.

Nur mit Berechtigung zugänglich

Mc Ardle BA, Dowsley TF, DeKemp RA, Wells GA, Beanlands RS. Does Rubidium-82 PET have superior accuracy to SPECT perfusion imaging for the diagnosis of obstructive coronary disease? J Am Coll Cardiol. 2012;60:1828–37.CrossRefPubMed

Majmudar MD, Murthy VL, Shah RV, Kolli S, Mousavi N, Foster CR, et al. Quantification of coronary flow reserve in patients with ischaemic and non-ischaemic cardiomyopathy and its association with clinical outcomes. Eur Heart J Cardiovasc Imaging. 2015;16:900–9.CrossRefPubMedPubMedCentral

de Kemp RA, Yoshinaga K, Beanlands RSB. Will 3-dimensional PET-CT enable the routine quantification of myocardial blood flow? J Nucl Cardiol. 2007;14:380–97.CrossRef

Renaud JM, Yip K, Guimond J, Trottier M, Pibarot P, Turcotte E, et al. Characterization of 3-dimensional PET systems for accurate quantification of myocardial blood flow. J Nucl Med. 2017;58:103–9.CrossRefPubMed

Slomka PJ, Pan T, Germano G. Recent advances and future progress in PET instrumentation. Semin Nucl Med. 2016;46:5–19.CrossRefPubMed

Nguyen NC, Vercher-Conejero JL, Sattar A, Miller MA, Maniawski PJ, Jordan DW, et al. Image quality and diagnostic performance of a digital PET prototype in patients with oncologic diseases: initial experience and comparison with analog PET. J Nucl Med. 2015;56:1378–85.CrossRefPubMed

Miller M, Zhang J, Binzel K, Griesmer J, Laurence T, Narayanan M, et al. Characterization of the vereos digital photon counting PET system. J Nucl Med. 2015;56:434.

Kolthammer JA, Su K-H, Grover A, Narayanan M, Jordan DW, Muzic RF. Performance evaluation of the ingenuity TF PET/CT scanner with a focus on high count-rate conditions. Phys Med Biol. 2014;59:3843–59.CrossRefPubMedPubMedCentral

Renaud JM, Moody JB, DeKemp RA. Reply: variation in maximum counting rates during myocardial blood flow quantification using 82 Rb PET. J Nucl Med. 2017;58:519–20.CrossRefPubMed

10.

van Dijk JD, Jager PL, van Osch JAC, van Dalen JA. Variation in maximum counting rates during myocardial blood flow quantification using 82 Rb PET. J Nucl Med. 2017;58:518–9.CrossRefPubMed

11.

Huizing ED, van Dijk JD, van Dalen JA, Timmer JR, Arkies H, Slump CH, et al. Minimizing rubidium-82 tracer activity for relative PET myocardial perfusion imaging. Nucl Med Commun. 2017;38:708–14.CrossRefPubMed

Titel: Comparison of maximal Rubidium-82 activities for myocardial blood flow quantification between digital and conventional PET systems
verfasst von: Joris D. van Dijk, MSc, PhD
Pieter L. Jager, MD, PhD
Jochen A. C. van Osch, MSc
Maryam Khodaverdi, PhD
Jorn A. van Dalen, PhD
Publikationsdatum: 01.08.2019
Verlag: Springer International Publishing
Erschienen in: Journal of Nuclear Cardiology / Ausgabe 4/2019
Print ISSN: 1071-3581
Elektronische ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-017-1156-9

Update Kardiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Comparison of maximal Rubidium-82 activities for myocardial blood flow quantification between digital and conventional PET systems