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01.12.2019 | Original Article

Simultaneous determination of dynamic cardiac metabolism and function using PET/MRI

verfasst von: Gregory P. Barton, PhD, Lauren Vildberg, Kara Goss, MD, Niti Aggarwal, MD, Marlowe Eldridge, MD, Alan B. McMillan, PhD

Erschienen in: Journal of Nuclear Cardiology | Ausgabe 6/2019

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Abstract

Background

Cardiac metabolic changes in heart disease precede overt contractile dysfunction. However, metabolism and function are not typically assessed together in clinical practice. The purpose of this study was to develop a cardiac positron emission tomography/magnetic resonance (PET/MR) stress test to assess the dynamic relationship between contractile function and metabolism in a preclinical model.

Methods

Following an overnight fast, healthy pigs (45-50 kg) were anesthetized and mechanically ventilated. ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) solution was administered intravenously at a constant rate of 0.01 mL/s for 60 minutes. A cardiac PET/MR stress test was performed using normoxic gas (F_IO₂ = .209) and hypoxic gas (F_IO₂ = .12). Simultaneous cardiac imaging was performed on an integrated 3T PET/MR scanner.

Results

Hypoxic stress induced a significant increase in heart rate, cardiac output, left ventricular (LV) ejection fraction (EF), and peak torsion. There was a significant decline in arterial SpO₂, LV end-diastolic and end-systolic volumes in hypoxia. Increased LV systolic function was coupled with an increase in myocardial FDG uptake (Ki) during hypoxic stress.

Conclusion

PET/MR with continuous FDG infusion captures dynamic changes in both cardiac metabolism and contractile function. This technique warrants evaluation in human cardiac disease for assessment of subtle functional and metabolic abnormalities.

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Titel: Simultaneous determination of dynamic cardiac metabolism and function using PET/MRI
verfasst von: Gregory P. Barton, PhD
Lauren Vildberg
Kara Goss, MD
Niti Aggarwal, MD
Marlowe Eldridge, MD
Alan B. McMillan, PhD
Publikationsdatum: 01.12.2019
Verlag: Springer International Publishing
Erschienen in: Journal of Nuclear Cardiology / Ausgabe 6/2019
Print ISSN: 1071-3581
Elektronische ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-018-1287-7

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Simultaneous determination of dynamic cardiac metabolism and function using PET/MRI