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01.02.2020 | Original Article

Diagnostic yield of ¹⁸F-FDG PET/CT in suspected diagnosis of vascular graft infection: A prospective cohort study

verfasst von: Hans Bowles, MD, Juan Ambrosioni, MD, PhD, Gaspar Mestres, MD, PhD, Marta Hernández-Meneses, MD, Nuria Sánchez, MD, Jaime Llopis, MD, PhD, Xavier Yugueros, MD, Manel Almela, MD, Asunción Moreno, MD, PhD, Vicenç Riambau, MD, PhD, David Fuster, MD, PhD, Jose M. Miró, MD, PhD, Hospital Clinic Endocarditis Study Group

Erschienen in: Journal of Nuclear Cardiology | Ausgabe 1/2020

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Abstract

Background

Prosthetic vascular graft infection (PVGI) is a severe complication associated with high morbidity and mortality. Clinical diagnosis is complex, requiring image testing such as CT angiography or leukocyte scintigraphy, which has considerable limitations. The aim of this study was to know the diagnostic yield of PET/CT with ¹⁸F-Fluorodeoxyglucose (¹⁸F-FDG) in patients with suspected PVGI.

Methods

We performed a prospective cohort study including 49 patients with suspected PVGI, median age of 62 ± 14 years. Three uptake patterns were defined following published recommendations: (i) focal, (ii) patched (PVGI criteria), and (iii) diffuse (no PVGI criterion).

Results

Sensitivity, specificity, and positive and negative predictive values for ¹⁸F-FDG-PET/CT were 88%, 79%, 67%, and 93%, respectively. ¹⁸F-FDG-PET/CT identified 14/16 cases of PVGI showing a focal (n = 10) or patched pattern (n = 4), being true negative in 26/33 cases with either a diffuse pattern (n = 16) or without uptake (n = 10). Five of the seven false-positive cases (71%) showed a patched pattern and all coincided with the application of adhesives for PVG placement.

Conclusions

¹⁸F-FDG-PET/CT is a useful technique for the diagnosis of PVGI. A patched pattern on PET/CT in patients in whom adhesives were applied for prosthetic vascular graft placement does not indicate infection.

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Titel: Diagnostic yield of 18F-FDG PET/CT in suspected diagnosis of vascular graft infection: A prospective cohort study
verfasst von: Hans Bowles, MD
Juan Ambrosioni, MD, PhD
Gaspar Mestres, MD, PhD
Marta Hernández-Meneses, MD
Nuria Sánchez, MD
Jaime Llopis, MD, PhD
Xavier Yugueros, MD
Manel Almela, MD
Asunción Moreno, MD, PhD
Vicenç Riambau, MD, PhD
David Fuster, MD, PhD
Jose M. Miró, MD, PhD
Hospital Clinic Endocarditis Study Group
Publikationsdatum: 01.02.2020
Verlag: Springer International Publishing
Erschienen in: Journal of Nuclear Cardiology / Ausgabe 1/2020
Print ISSN: 1071-3581
Elektronische ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-018-1337-1

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Diagnostic yield of ¹⁸F-FDG PET/CT in suspected diagnosis of vascular graft infection: A prospective cohort study