Erschienen in:
11.06.2020 | ORIGINAL ARTICLE
Observer repeatability and interscan reproducibility of 18F-sodium fluoride coronary microcalcification activity
verfasst von:
Evangelos Tzolos, MD, Jacek Kwiecinski, MD, PhD, Martin Lyngby Lassen, PhD, Sebastien Cadet, MS, Philip D. Adamson, MD, PhD, Alastair J. Moss, MD, PhD, Nikhil Joshi, MD, PhD, Michelle C. Williams, MD, PhD, Edwin J. R. van Beek, MD, PhD, Damini Dey, PhD, Daniel S. Berman, MD, Marc R. Dweck, MD, PhD, David E. Newby, MD, PhD, Piotr J. Slomka, PhD
Erschienen in:
Journal of Nuclear Cardiology
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Ausgabe 1/2022
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Abstract
Background
We aimed to establish the observer repeatability and interscan reproducibility of coronary 18F-sodium-fluoride positron emission tomography (PET) uptake using a novel semi-automated approach, coronary microcalcification activity (CMA).
Methods
Patients with multivessel coronary artery disease underwent repeated hybrid PET and computed tomography angiography (CTA) imaging (PET/CTA). CMA was defined as the integrated standardized uptake values (SUV) in the entire coronary tree exceeding 2 standard deviations above the background SUV. Coefficients of repeatability between the same observer (intraobserver repeatability), between 2 observers (interobserver repeatability) and coefficient of reproducibility between 2 scans (interscan reproducibility), were determined at vessel and patient level.
Results
In 19 patients, CMA was assessed twice in 43 coronary vessels on two PET/CT scans performed 12 ± 5 days apart. There was excellent intraclass correlation for intraobserver and interobserver repeatability as well as interscan reproducibility (all ≥ 0.991). There was 100% intraobserver, interobserver and interscan agreement for the presence (CMA > 0) or absence (CMA = 0) of coronary18F-NaF uptake. Mean CMA was 3.12 ± 0.62 with coefficients of repeatability of ≤ 10% for all measures: intraobserver 0.24 and 0.22, interobserver 0.30 and 0.29 and interscan 0.33 and 0.32 at a per-vessel and per-patient level, respectively.
Conclusions
CMA is a repeatable and reproducible global measure of coronary atherosclerotic activity.